CA2876703A1 - Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury - Google Patents
Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury Download PDFInfo
- Publication number
- CA2876703A1 CA2876703A1 CA2876703A CA2876703A CA2876703A1 CA 2876703 A1 CA2876703 A1 CA 2876703A1 CA 2876703 A CA2876703 A CA 2876703A CA 2876703 A CA2876703 A CA 2876703A CA 2876703 A1 CA2876703 A1 CA 2876703A1
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- alkyl
- alkenyl
- substituted
- alkynyl
- aryl
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- Heart & Thoracic Surgery (AREA)
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- Surgery (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201261666535P | 2012-06-29 | 2012-06-29 | |
| US61/666,535 | 2012-06-29 | ||
| US201361782894P | 2013-03-14 | 2013-03-14 | |
| US61/782,894 | 2013-03-14 | ||
| PCT/US2013/048697 WO2014005080A1 (en) | 2012-06-29 | 2013-06-28 | Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury |
Publications (1)
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| CA2876703A1 true CA2876703A1 (en) | 2014-01-03 |
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| CA2876703A Abandoned CA2876703A1 (en) | 2012-06-29 | 2013-06-28 | Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury |
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| US (1) | US20150174123A1 (https=) |
| EP (1) | EP2870161B1 (https=) |
| JP (2) | JP6262225B2 (https=) |
| CN (1) | CN104619710B (https=) |
| CA (1) | CA2876703A1 (https=) |
| WO (1) | WO2014005080A1 (https=) |
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| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| EP2867239A4 (en) | 2012-06-29 | 2015-12-23 | Lixte Biotechnology Inc | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DIABETES |
| KR20160004299A (ko) | 2013-04-09 | 2016-01-12 | 릭스트 바이오테크놀로지, 인코포레이티드 | 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형 |
| EP3143026B1 (en) | 2014-05-13 | 2024-07-10 | Novartis AG | Compounds and compositions for inducing chondrogenesis |
| EP3171870B1 (en) * | 2014-07-24 | 2021-10-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes |
| WO2016040877A1 (en) * | 2014-09-12 | 2016-03-17 | Lixte Biotechnology, Inc. | Human dosing of phosphatase inhibitor |
| CA2977256C (en) | 2015-02-19 | 2023-08-08 | John S. Kovach | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders |
| ES2985668T3 (es) | 2015-05-15 | 2024-11-06 | Lixte Biotechnology Inc | Profármacos de oxabicicloheptano para uso en el tratamiento del cáncer |
| EP4324477A3 (en) | 2016-12-08 | 2024-05-22 | Lixte Biotechnology, Inc. | Oxabicycloheptanes for modulation of immune response |
| WO2019185708A1 (en) | 2018-03-28 | 2019-10-03 | Georg-August-Universitaet Goettingen, Stiftung Oeffentlichen Rechts, Universitaetsmedizin | Prevention or treatment of chronic organ injury |
| CN118791500B (zh) * | 2024-06-17 | 2025-11-21 | 中国药科大学 | 7-氧杂双环[2.2.1]庚烷-2,3-二羧酸类衍生物及其制备方法和应用 |
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| US4931460A (en) * | 1987-09-17 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Post-ischemic myocardial dysfunction using thromboxane A2 antagonists |
| WO1998014606A1 (en) * | 1996-10-04 | 1998-04-09 | South Alabama Medical Science Foundation | Method for diminishing myocardial infarction using protein phosphatase inhibitors |
| BRPI0806365B8 (pt) | 2007-02-06 | 2021-05-25 | Lixte Biotechnology Holdings Inc | composto, uso do composto, composição farmacêutica e uso da composição farmacêutica |
| WO2010014141A1 (en) * | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase |
| WO2010014220A1 (en) | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| KR20160004299A (ko) * | 2013-04-09 | 2016-01-12 | 릭스트 바이오테크놀로지, 인코포레이티드 | 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형 |
| WO2016040877A1 (en) * | 2014-09-12 | 2016-03-17 | Lixte Biotechnology, Inc. | Human dosing of phosphatase inhibitor |
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2013
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- 2013-06-28 EP EP13808660.8A patent/EP2870161B1/en not_active Not-in-force
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- 2013-06-28 CN CN201380035527.1A patent/CN104619710B/zh not_active Expired - Fee Related
- 2013-06-28 US US14/408,208 patent/US20150174123A1/en not_active Abandoned
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2017
- 2017-10-25 JP JP2017206285A patent/JP2018048178A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014005080A1 (en) | 2014-01-03 |
| EP2870161A4 (en) | 2015-12-23 |
| HK1209424A1 (en) | 2016-04-01 |
| JP6262225B2 (ja) | 2018-01-17 |
| JP2015522032A (ja) | 2015-08-03 |
| EP2870161B1 (en) | 2018-08-08 |
| US20150174123A1 (en) | 2015-06-25 |
| EP2870161A1 (en) | 2015-05-13 |
| JP2018048178A (ja) | 2018-03-29 |
| CN104619710A (zh) | 2015-05-13 |
| CN104619710B (zh) | 2017-09-22 |
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