CA2876529C - Method for treating a gd2 positive cancer - Google Patents
Method for treating a gd2 positive cancer Download PDFInfo
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- CA2876529C CA2876529C CA2876529A CA2876529A CA2876529C CA 2876529 C CA2876529 C CA 2876529C CA 2876529 A CA2876529 A CA 2876529A CA 2876529 A CA2876529 A CA 2876529A CA 2876529 C CA2876529 C CA 2876529C
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
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- Cell Biology (AREA)
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- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/061618 WO2013189516A1 (en) | 2012-06-18 | 2012-06-18 | Method for treating a gd2 positive cancer |
| EPPCT/EP2012/061618 | 2012-06-18 | ||
| PCT/EP2012/064970 WO2013189554A1 (en) | 2012-06-18 | 2012-07-31 | Method for treating a gd2 positive cancer |
Publications (2)
| Publication Number | Publication Date |
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| CA2876529A1 CA2876529A1 (en) | 2013-12-27 |
| CA2876529C true CA2876529C (en) | 2023-09-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2876529A Active CA2876529C (en) | 2012-06-18 | 2012-07-31 | Method for treating a gd2 positive cancer |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10294305B2 (enExample) |
| JP (1) | JP6283665B2 (enExample) |
| KR (1) | KR101927118B1 (enExample) |
| CN (1) | CN104487088A (enExample) |
| AP (1) | AP2014008129A0 (enExample) |
| AU (1) | AU2012383254B2 (enExample) |
| BR (1) | BR112014031806A8 (enExample) |
| CA (1) | CA2876529C (enExample) |
| EA (1) | EA038188B1 (enExample) |
| HK (1) | HK1203375A1 (enExample) |
| IL (1) | IL235696A0 (enExample) |
| MX (1) | MX377157B (enExample) |
| SG (2) | SG11201408487WA (enExample) |
| WO (2) | WO2013189516A1 (enExample) |
| ZA (1) | ZA201407961B (enExample) |
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| WO2013189516A1 (en) | 2012-06-18 | 2013-12-27 | Apeiron Biologics Ag | Method for treating a gd2 positive cancer |
| EP4218811A1 (en) | 2012-06-18 | 2023-08-02 | Apeiron Biologics AG | Method for treating a gd2 positive cancer |
| ES2768649T3 (es) | 2013-11-21 | 2020-06-23 | Apeiron Biologics Ag | Preparaciones para tratar un cáncer positivo para GD2 |
| US9840566B2 (en) | 2013-11-21 | 2017-12-12 | Apeiron Biologics Ag | Preparations and methods for treating a GD2 positive cancer |
| DK3154583T3 (da) * | 2014-06-04 | 2021-03-22 | Biontech Res And Development Inc | Humane monoklonale antistoffer mod gangliosid gd2 |
| US10329323B2 (en) | 2014-07-25 | 2019-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Method for purifying antibodies using PBS |
| WO2017055385A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xgd2 bispecific t cell activating antigen binding molecules |
| CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| CA3076482A1 (en) * | 2017-09-21 | 2019-03-28 | Umc Utrecht Holding B.V. | Anti-gd2 antibody for the treatment of neuroblastoma |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CN108948211B (zh) * | 2018-07-24 | 2021-08-20 | 北京美康基免生物科技有限公司 | 一种基于靶向gd2的嵌合抗原受体及其应用 |
| WO2020165402A1 (en) | 2019-02-14 | 2020-08-20 | Westfälische Wilhelms-Universität Münster | Gd2-upregulation by ezh2 inhibition in cancer therapy |
| CN114096240A (zh) | 2019-05-17 | 2022-02-25 | 癌症预防制药股份有限公司 | 用于治疗家族性腺瘤性息肉病的方法 |
| CA3141327A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Operations, Inc. | Madcam targeted immunotolerance |
| ES3031393T3 (en) * | 2019-08-01 | 2025-07-08 | Univ Mie | Gd2 binding molecule |
| EP4093429A4 (en) * | 2019-11-26 | 2024-05-22 | University of Utah Research Foundation | COMPOSITIONS AND METHODS FOR REGULATION OF HLA CLASS I ON TUMOR CELLS |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| JP2023532753A (ja) | 2020-07-06 | 2023-07-31 | イーユーエスエー ファーマ （ユーケー） リミテッド | Ｇｄ２陽性がんを治療するための方法 |
| EP4116330A1 (en) * | 2021-07-05 | 2023-01-11 | Trion Research GmbH | Multispecific antibodies with monovalent binding to tumor-associated antigens causing no or reduced nerve pain in the treatment of cancer |
| JP2024524527A (ja) * | 2021-07-05 | 2024-07-05 | トリオン リサーチ ゲーエムベーハー | がん治療において神経疼痛の消失または軽減をもたらす腫瘍関連抗原に結合する多重特異性抗体 |
| EP4194471A1 (en) * | 2021-12-10 | 2023-06-14 | Y-Mabs Therapeutics, Inc. | Anti-gd2 administration regimen |
| GB202307103D0 (en) | 2023-05-12 | 2023-06-28 | Prinses Maxima Centrum Voor Kinderoncologie B V | Method for detecting a GD2 positive cancer |
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| US4863713A (en) | 1986-06-23 | 1989-09-05 | The Board Of Trustees Of Leland Stanford Jr. Univ. | Method and system for administering therapeutic and diagnostic agents |
| EP2325205A3 (en) * | 2000-12-28 | 2011-10-12 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
| US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| PT1572748E (pt) * | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Anticorpo humanizado (h14.18) do anticorpo 14.18 de rato que se liga ao gd2 e a sua fusão com a il-2 |
| WO2005070967A2 (en) | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
| CN101292036B (zh) | 2005-10-21 | 2016-04-13 | 弗·哈夫曼-拉罗切有限公司 | 用于重组表达多肽的方法 |
| EP1916257A1 (en) | 2006-10-27 | 2008-04-30 | Charite-Universitätsmedizin Berlin | GD2 peptide mimotopes for anticancer vaccination |
| TWI466684B (zh) | 2008-06-30 | 2015-01-01 | Morphotek Inc | 抗ｇｄ２抗體及其相關方法及用途 |
| NZ603581A (en) * | 2010-06-19 | 2015-05-29 | Sloan Kettering Inst Cancer | Anti-gd2 antibodies |
| US8435972B2 (en) * | 2010-09-02 | 2013-05-07 | Emory University | Method for the treatment of central nervous system cancers and compositions related thereto |
| DK2771364T3 (da) | 2011-10-27 | 2019-08-19 | Genmab As | Fremstilling af heterodimere proteiner |
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| US9840566B2 (en) * | 2013-11-21 | 2017-12-12 | Apeiron Biologics Ag | Preparations and methods for treating a GD2 positive cancer |
| ES2768649T3 (es) | 2013-11-21 | 2020-06-23 | Apeiron Biologics Ag | Preparaciones para tratar un cáncer positivo para GD2 |
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2017
- 2017-09-11 US US15/700,538 patent/US11447565B2/en active Active
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2019
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2022
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Also Published As
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|---|---|
| EA038188B1 (ru) | 2021-07-21 |
| CN104487088A (zh) | 2015-04-01 |
| AU2012383254A1 (en) | 2014-11-20 |
| KR20150030650A (ko) | 2015-03-20 |
| AP2014008129A0 (en) | 2014-12-31 |
| US20180134801A1 (en) | 2018-05-17 |
| WO2013189516A1 (en) | 2013-12-27 |
| BR112014031806A8 (pt) | 2018-01-16 |
| US20200055953A1 (en) | 2020-02-20 |
| BR112014031806A2 (pt) | 2017-08-29 |
| JP2015521607A (ja) | 2015-07-30 |
| JP6283665B2 (ja) | 2018-02-21 |
| CA2876529A1 (en) | 2013-12-27 |
| ZA201407961B (en) | 2015-10-28 |
| AU2012383254B2 (en) | 2017-12-14 |
| US11447565B2 (en) | 2022-09-20 |
| KR101927118B1 (ko) | 2019-03-12 |
| WO2013189554A1 (en) | 2013-12-27 |
| EA201500019A1 (ru) | 2015-05-29 |
| SG11201408487WA (en) | 2015-02-27 |
| HK1203375A1 (en) | 2015-10-30 |
| US20230340148A1 (en) | 2023-10-26 |
| US10294305B2 (en) | 2019-05-21 |
| IL235696A0 (en) | 2015-01-29 |
| SG10201610532QA (en) | 2017-02-27 |
| US20140170155A1 (en) | 2014-06-19 |
| MX377157B (es) | 2025-03-07 |
| MX2014013858A (es) | 2015-02-12 |
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