CA2872482C - Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 - Google Patents
Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 Download PDFInfo
- Publication number
- CA2872482C CA2872482C CA2872482A CA2872482A CA2872482C CA 2872482 C CA2872482 C CA 2872482C CA 2872482 A CA2872482 A CA 2872482A CA 2872482 A CA2872482 A CA 2872482A CA 2872482 C CA2872482 C CA 2872482C
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- Prior art keywords
- cwpv
- ribotype
- difficile
- antibodies
- determining
- Prior art date
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Links
- 241000193163 Clostridioides difficile Species 0.000 title claims abstract description 45
- 210000002421 cell wall Anatomy 0.000 title abstract description 8
- 108090000623 proteins and genes Proteins 0.000 title description 11
- 102000004169 proteins and genes Human genes 0.000 title description 7
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- 102000018697 Membrane Proteins Human genes 0.000 description 2
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- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 231100000221 frame shift mutation induction Toxicity 0.000 description 2
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- 238000003906 pulsed field gel electrophoresis Methods 0.000 description 2
- 231100000033 toxigenic Toxicity 0.000 description 2
- 230000001551 toxigenic effect Effects 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 102100021324 5-azacytidine-induced protein 2 Human genes 0.000 description 1
- 241001148536 Bacteroides sp. Species 0.000 description 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645964P | 2012-05-11 | 2012-05-11 | |
| US61/645,964 | 2012-05-11 | ||
| US13/889,670 US9133527B2 (en) | 2012-05-11 | 2013-05-08 | Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027 |
| US13/889,670 | 2013-05-08 | ||
| PCT/US2013/040399 WO2013170065A1 (en) | 2012-05-11 | 2013-05-09 | Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2872482A1 CA2872482A1 (en) | 2013-11-14 |
| CA2872482C true CA2872482C (en) | 2017-10-31 |
Family
ID=49548891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2872482A Active CA2872482C (en) | 2012-05-11 | 2013-05-09 | Cell wall protein cwpv (cd0514) as a diagnostic marker for clostridium difficile ribotype 027 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9133527B2 (enExample) |
| EP (1) | EP2847590B1 (enExample) |
| JP (1) | JP6165238B2 (enExample) |
| AU (1) | AU2013259381B2 (enExample) |
| CA (1) | CA2872482C (enExample) |
| ES (1) | ES2628334T3 (enExample) |
| NZ (1) | NZ702383A (enExample) |
| WO (1) | WO2013170065A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI126289B (en) * | 2014-12-19 | 2016-09-15 | Mobidiag Ltd | Method for detecting the presence of a hypervirulent strain of Clostridium difficile |
| CN106814189B (zh) * | 2016-12-20 | 2018-10-26 | 成都金思唯生物技术有限公司 | 一种检测艰难梭菌的试剂盒及其用途 |
| US20190211377A1 (en) * | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965375A (en) * | 1997-04-04 | 1999-10-12 | Biosite Diagnostics | Diagnostic tests and kits for Clostridium difficile |
| ES2564169T3 (es) * | 2004-11-24 | 2016-03-18 | Techlab, Inc. | Dispositivo y método para la detección de analitos |
| CA2714720A1 (en) * | 2008-02-28 | 2009-09-03 | 3M Innovative Properties Company | Antibodies to clostridium difficile spores and uses thereof |
| ATE478967T1 (de) * | 2008-09-16 | 2010-09-15 | Oesterreichische Agentur Fuer | Pcr-ribotyping |
| US20120028819A1 (en) * | 2009-04-07 | 2012-02-02 | Koninklijke Philips Electronics N.V. | Method for the detection and characterization of a toxinogenic clostridium difficile strain |
| US8889363B2 (en) | 2009-07-27 | 2014-11-18 | Biodics | Method for the detection and identification of a variant C. difficile strain in a sample |
| JP5591332B2 (ja) * | 2009-07-27 | 2014-09-17 | バイオディクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 試料中における変異したｃ．ディフィシル菌株を検出および同定するための方法 |
| US20120276060A1 (en) | 2011-04-29 | 2012-11-01 | Techlab, Inc. | Fecal lactoferrin as a biomarker for determining disease severity and for treating infection in patients with clostridium difficile disease |
| US8790880B2 (en) | 2011-09-26 | 2014-07-29 | Techlab, Inc. | Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile |
-
2013
- 2013-05-08 US US13/889,670 patent/US9133527B2/en active Active
- 2013-05-09 JP JP2015511712A patent/JP6165238B2/ja active Active
- 2013-05-09 AU AU2013259381A patent/AU2013259381B2/en active Active
- 2013-05-09 CA CA2872482A patent/CA2872482C/en active Active
- 2013-05-09 WO PCT/US2013/040399 patent/WO2013170065A1/en not_active Ceased
- 2013-05-09 ES ES13787811.2T patent/ES2628334T3/es active Active
- 2013-05-09 EP EP13787811.2A patent/EP2847590B1/en active Active
- 2013-05-09 NZ NZ702383A patent/NZ702383A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9133527B2 (en) | 2015-09-15 |
| EP2847590B1 (en) | 2017-04-05 |
| CA2872482A1 (en) | 2013-11-14 |
| WO2013170065A1 (en) | 2013-11-14 |
| JP6165238B2 (ja) | 2017-07-19 |
| NZ702383A (en) | 2016-12-23 |
| JP2015517658A (ja) | 2015-06-22 |
| US20130302813A1 (en) | 2013-11-14 |
| EP2847590A1 (en) | 2015-03-18 |
| AU2013259381A1 (en) | 2014-12-04 |
| AU2013259381B2 (en) | 2018-08-16 |
| ES2628334T3 (es) | 2017-08-02 |
| EP2847590A4 (en) | 2015-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150223 |