CA2870684A1 - Use of high dose laquinimod for treating multiple sclerosis - Google Patents

Use of high dose laquinimod for treating multiple sclerosis Download PDF

Info

Publication number
CA2870684A1
CA2870684A1 CA2870684A CA2870684A CA2870684A1 CA 2870684 A1 CA2870684 A1 CA 2870684A1 CA 2870684 A CA2870684 A CA 2870684A CA 2870684 A CA2870684 A CA 2870684A CA 2870684 A1 CA2870684 A1 CA 2870684A1
Authority
CA
Canada
Prior art keywords
laquinimod
patient
administration
human patient
multiple sclerosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2870684A
Other languages
English (en)
French (fr)
Inventor
Dan Bar-Zohar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49514859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2870684(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CA2870684A1 publication Critical patent/CA2870684A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2870684A 2012-05-02 2013-05-01 Use of high dose laquinimod for treating multiple sclerosis Abandoned CA2870684A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261641389P 2012-05-02 2012-05-02
US61/641,389 2012-05-02
PCT/US2013/039090 WO2013166166A1 (en) 2012-05-02 2013-05-01 Use of high dose laquinimod for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
CA2870684A1 true CA2870684A1 (en) 2013-11-07

Family

ID=49514859

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2870684A Abandoned CA2870684A1 (en) 2012-05-02 2013-05-01 Use of high dose laquinimod for treating multiple sclerosis

Country Status (21)

Country Link
US (3) US20130303569A1 (cg-RX-API-DMAC7.html)
EP (1) EP2844255A4 (cg-RX-API-DMAC7.html)
JP (2) JP2015515985A (cg-RX-API-DMAC7.html)
KR (1) KR20150013658A (cg-RX-API-DMAC7.html)
CN (2) CN105832733A (cg-RX-API-DMAC7.html)
AR (1) AR090885A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013256352A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014027010A2 (cg-RX-API-DMAC7.html)
CA (1) CA2870684A1 (cg-RX-API-DMAC7.html)
CL (1) CL2014002935A1 (cg-RX-API-DMAC7.html)
EA (1) EA201492010A1 (cg-RX-API-DMAC7.html)
HK (1) HK1206246A1 (cg-RX-API-DMAC7.html)
IL (1) IL235337A0 (cg-RX-API-DMAC7.html)
MX (1) MX2014013039A (cg-RX-API-DMAC7.html)
PE (1) PE20150161A1 (cg-RX-API-DMAC7.html)
PH (1) PH12014502447A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201406594UA (cg-RX-API-DMAC7.html)
TW (2) TW201347762A (cg-RX-API-DMAC7.html)
UY (1) UY34775A (cg-RX-API-DMAC7.html)
WO (1) WO2013166166A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201408820B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106344576A (zh) 2011-10-12 2017-01-25 泰华制药工业有限公司 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症
TW201345527A (zh) 2012-02-03 2013-11-16 Teva Pharma 拉喹莫德於治療對第一線抗-TNFα療法無效之克隆氏症患者之用途
AR090073A1 (es) 2012-02-16 2014-10-15 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinolinacarboxamida, su preparacion y usos
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
AU2013329348A1 (en) * 2012-10-12 2015-05-28 Teva Pharmaceutical Industries Ltd. Laquinimod for reducing thalamic damage in multiple sclerosis
HK1215210A1 (zh) 2012-11-07 2016-08-19 Teva Pharmaceutical Industries Ltd. 拉喹莫德胺盐
HK1218251A1 (zh) * 2013-02-15 2017-02-10 Teva Pharmaceutical Industries Ltd. 用拉喹莫德治疗多发性硬化症
EA201591699A1 (ru) 2013-03-14 2016-02-29 Тева Фармасьютикал Индастриз Лтд. Кристаллы лаквинимода натрия и улучшенный способ их производства
AR098924A1 (es) * 2013-12-23 2016-06-22 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida
US20150306088A1 (en) * 2014-04-29 2015-10-29 Teva Pharmaceutical Industries, Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
WO2017027512A1 (en) * 2015-08-13 2017-02-16 Teva Pharmaceutical Industries Ltd. Use of laquinimod to treat traumatic brain injury
US20190108912A1 (en) * 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
WO2020016850A1 (en) * 2018-07-20 2020-01-23 Merck Patent Gmbh A substituted amino-pyrimidine compound for use in a method for treatment and prevention of multiple sclerosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
HRP20160455T1 (hr) * 2004-09-09 2016-07-15 Yeda Research And Development Co., Ltd. Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
US20080118553A1 (en) * 2006-06-12 2008-05-22 Anton Frenkel Tannate salt form of polypeptide mixtures, their preparation and use
US20100322900A1 (en) * 2009-06-19 2010-12-23 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with laquinimod
US20130035390A1 (en) * 2010-01-13 2013-02-07 Ramot At Tel-Aviv University Ltd. Treatment of multiple sclerosis
CN106344576A (zh) * 2011-10-12 2017-01-25 泰华制药工业有限公司 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症
HK1218251A1 (zh) * 2013-02-15 2017-02-10 Teva Pharmaceutical Industries Ltd. 用拉喹莫德治疗多发性硬化症

Also Published As

Publication number Publication date
US20160000775A1 (en) 2016-01-07
PH12014502447A1 (en) 2015-01-12
PE20150161A1 (es) 2015-02-22
AR090885A1 (es) 2014-12-10
UY34775A (es) 2013-11-29
CN104284663A (zh) 2015-01-14
CN105832733A (zh) 2016-08-10
US20130303569A1 (en) 2013-11-14
WO2013166166A1 (en) 2013-11-07
TW201804997A (zh) 2018-02-16
CL2014002935A1 (es) 2015-03-06
US20150265592A1 (en) 2015-09-24
IL235337A0 (en) 2014-12-31
TW201347762A (zh) 2013-12-01
MX2014013039A (es) 2015-02-04
KR20150013658A (ko) 2015-02-05
JP2015515985A (ja) 2015-06-04
JP2017222691A (ja) 2017-12-21
EA201492010A1 (ru) 2015-06-30
EP2844255A4 (en) 2015-10-14
BR112014027010A2 (pt) 2017-06-27
SG11201406594UA (en) 2014-11-27
EP2844255A1 (en) 2015-03-11
ZA201408820B (en) 2016-06-29
HK1206246A1 (en) 2016-01-08
AU2013256352A1 (en) 2014-11-27

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Publication Publication Date Title
DK2442651T3 (en) Treatment of multiple sclerosis with laquinimod
CA2870684A1 (en) Use of high dose laquinimod for treating multiple sclerosis
CA2820586A1 (en) Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients
US20180064702A1 (en) Treatment of progressive forms of multiple sclerosis with laquinimod
US9662322B2 (en) Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status
HK1224555A1 (en) Use of high dose laquinimod for treating multiple sclerosis
HK1169563B (en) Treatment of multiple sclerosis with laquinimod

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20190501