CA2869718C - Antibacterial quinoline derivatives - Google Patents
Antibacterial quinoline derivatives Download PDFInfo
- Publication number
- CA2869718C CA2869718C CA2869718A CA2869718A CA2869718C CA 2869718 C CA2869718 C CA 2869718C CA 2869718 A CA2869718 A CA 2869718A CA 2869718 A CA2869718 A CA 2869718A CA 2869718 C CA2869718 C CA 2869718C
- Authority
- CA
- Canada
- Prior art keywords
- 6alkyl
- compound
- formula
- compounds
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12165934 | 2012-04-27 | ||
| EP12165934.6 | 2012-04-27 | ||
| PCT/EP2013/058703 WO2013160435A1 (en) | 2012-04-27 | 2013-04-26 | Antibacterial quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2869718A1 CA2869718A1 (en) | 2013-10-31 |
| CA2869718C true CA2869718C (en) | 2021-05-11 |
Family
ID=48227271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2869718A Active CA2869718C (en) | 2012-04-27 | 2013-04-26 | Antibacterial quinoline derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9133167B2 (https=) |
| EP (1) | EP2841425B1 (https=) |
| JP (1) | JP6153604B2 (https=) |
| KR (1) | KR102110355B1 (https=) |
| CN (1) | CN104254527B (https=) |
| AU (1) | AU2013254674B2 (https=) |
| CA (1) | CA2869718C (https=) |
| DK (1) | DK2841425T3 (https=) |
| EA (1) | EA035443B1 (https=) |
| ES (1) | ES2576491T3 (https=) |
| IN (1) | IN2014MN02364A (https=) |
| MX (1) | MX355050B (https=) |
| PL (1) | PL2841425T3 (https=) |
| WO (1) | WO2013160435A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2607879T3 (es) * | 2012-04-27 | 2017-04-04 | Janssen Pharmaceutica N.V. | Derivados de quinolina antibacterianos |
| WO2016020836A1 (en) * | 2014-08-06 | 2016-02-11 | Novartis Ag | Quinolone derivatives as antibacterials |
| BR122023025283A2 (pt) * | 2016-03-07 | 2024-02-20 | Global Alliance For Tb Drug Development Inc | Compostos antibacterianos e seus usos |
| KR102574912B1 (ko) * | 2016-08-17 | 2023-09-07 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| KR102695633B1 (ko) * | 2021-12-17 | 2024-08-14 | 한국화학연구원 | 피리미딘을 포함하는 테트라하이드로이소퀴놀린 유도체 및 이의 결핵 치료제 용도 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018326A1 (en) | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| US6103905A (en) | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| ATE463482T1 (de) | 2002-07-25 | 2010-04-15 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| EA011277B1 (ru) | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные хинолина и их применение в качестве ингибиторов микобактерий |
| EA011359B1 (ru) * | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Замещенные хинолины и их применение в качестве микобактериальных ингибиторов |
| CA2554049C (en) | 2004-01-29 | 2012-12-18 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| PL1753427T3 (pl) | 2004-05-28 | 2008-09-30 | Janssen Pharmaceutica Nv | Zastosowanie podstawionych pochodnych chinoliny do leczenia chorób wywoływanych przez prątki lekooporne |
| WO2005123081A2 (en) | 2004-06-22 | 2005-12-29 | Janssen Pharmaceutica N.V. | (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia |
| PL1797115T3 (pl) | 2004-09-28 | 2017-12-29 | Janssen Pharmaceutica N.V. | Domena wiążąca bakteryjnej syntazy ATP |
| EE05394B1 (et) | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| CA2528849C (en) | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| JO3270B1 (ar) | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| KR101329587B1 (ko) | 2005-06-28 | 2013-11-15 | 얀센 파마슈티카 엔.브이. | 항균제로서의 퀴놀린 유도체 |
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO3077B1 (ar) | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| JO2837B1 (en) | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2684B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| CA2711912A1 (en) * | 2008-01-14 | 2009-07-23 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents |
| ES2607879T3 (es) * | 2012-04-27 | 2017-04-04 | Janssen Pharmaceutica N.V. | Derivados de quinolina antibacterianos |
-
2013
- 2013-04-26 CN CN201380021790.5A patent/CN104254527B/zh not_active Expired - Fee Related
- 2013-04-26 EP EP13719524.4A patent/EP2841425B1/en active Active
- 2013-04-26 ES ES13719524.4T patent/ES2576491T3/es active Active
- 2013-04-26 US US14/391,045 patent/US9133167B2/en active Active
- 2013-04-26 CA CA2869718A patent/CA2869718C/en active Active
- 2013-04-26 MX MX2014013056A patent/MX355050B/es active IP Right Grant
- 2013-04-26 AU AU2013254674A patent/AU2013254674B2/en not_active Ceased
- 2013-04-26 WO PCT/EP2013/058703 patent/WO2013160435A1/en not_active Ceased
- 2013-04-26 KR KR1020147031040A patent/KR102110355B1/ko not_active Expired - Fee Related
- 2013-04-26 PL PL13719524.4T patent/PL2841425T3/pl unknown
- 2013-04-26 JP JP2015507549A patent/JP6153604B2/ja not_active Expired - Fee Related
- 2013-04-26 IN IN2364MUN2014 patent/IN2014MN02364A/en unknown
- 2013-04-26 EA EA201491982A patent/EA035443B1/ru not_active IP Right Cessation
- 2013-04-26 DK DK13719524.4T patent/DK2841425T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2841425A1 (en) | 2015-03-04 |
| US9133167B2 (en) | 2015-09-15 |
| MX2014013056A (es) | 2014-12-10 |
| EA035443B1 (ru) | 2020-06-17 |
| CN104254527A (zh) | 2014-12-31 |
| PL2841425T3 (pl) | 2016-10-31 |
| KR102110355B1 (ko) | 2020-05-14 |
| IN2014MN02364A (https=) | 2015-08-14 |
| CN104254527B (zh) | 2017-05-31 |
| AU2013254674A1 (en) | 2014-10-16 |
| ES2576491T3 (es) | 2016-07-07 |
| JP6153604B2 (ja) | 2017-06-28 |
| AU2013254674B2 (en) | 2017-02-02 |
| JP2015518003A (ja) | 2015-06-25 |
| DK2841425T3 (en) | 2016-06-27 |
| MX355050B (es) | 2018-04-02 |
| WO2013160435A1 (en) | 2013-10-31 |
| EA201491982A1 (ru) | 2015-02-27 |
| US20150065502A1 (en) | 2015-03-05 |
| CA2869718A1 (en) | 2013-10-31 |
| HK1205514A1 (en) | 2015-12-18 |
| EP2841425B1 (en) | 2016-03-23 |
| KR20150013156A (ko) | 2015-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2669819C (en) | Antibacterial quinoline derivatives | |
| CA2869718C (en) | Antibacterial quinoline derivatives | |
| EP2099762B1 (en) | Antibacterial quinoline derivatives | |
| EP2099759B1 (en) | Antibacterial quinoline derivatives | |
| CA2614981C (en) | Antibacterial quinoline derivatives | |
| CA2668520C (en) | Antibacterial quinoline derivatives | |
| CA2668517C (en) | Antibacterial quinoline derivatives | |
| CA2668558C (en) | Antibacterial quinoline derivatives | |
| CA2869453A1 (en) | Antibacterial quinoline derivatives | |
| HK1205514B (en) | Antibacterial quinoline derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180412 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20251009 |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE Effective date: 20260122 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260209 |