CA2867092C - Sensor - Google Patents

Sensor Download PDF

Info

Publication number
CA2867092C
CA2867092C CA2867092A CA2867092A CA2867092C CA 2867092 C CA2867092 C CA 2867092C CA 2867092 A CA2867092 A CA 2867092A CA 2867092 A CA2867092 A CA 2867092A CA 2867092 C CA2867092 C CA 2867092C
Authority
CA
Canada
Prior art keywords
membrane
ros
sensor
quenching
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2867092A
Other languages
English (en)
French (fr)
Other versions
CA2867092A1 (en
Inventor
William Paterson
Nick BARWELL
Bruce Culbert
Barry Colin Crane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to CA3095821A priority Critical patent/CA3095821C/en
Publication of CA2867092A1 publication Critical patent/CA2867092A1/en
Application granted granted Critical
Publication of CA2867092C publication Critical patent/CA2867092C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2867092A 2012-03-15 2013-02-20 Sensor Active CA2867092C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3095821A CA3095821C (en) 2012-03-15 2013-02-20 Sensor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261611239P 2012-03-15 2012-03-15
US61/611,239 2012-03-15
PCT/GB2013/050407 WO2013136044A2 (en) 2012-03-15 2013-02-20 Sensor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3095821A Division CA3095821C (en) 2012-03-15 2013-02-20 Sensor

Publications (2)

Publication Number Publication Date
CA2867092A1 CA2867092A1 (en) 2013-09-19
CA2867092C true CA2867092C (en) 2022-12-13

Family

ID=47833300

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2867092A Active CA2867092C (en) 2012-03-15 2013-02-20 Sensor
CA3095821A Active CA3095821C (en) 2012-03-15 2013-02-20 Sensor

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3095821A Active CA3095821C (en) 2012-03-15 2013-02-20 Sensor

Country Status (8)

Country Link
US (3) US8940542B2 (enExample)
EP (1) EP2825095A2 (enExample)
JP (1) JP2015509803A (enExample)
CN (1) CN104168827A (enExample)
AU (1) AU2013234126A1 (enExample)
CA (2) CA2867092C (enExample)
IN (1) IN2014DN07535A (enExample)
WO (1) WO2013136044A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103533884B (zh) 2011-03-15 2016-06-01 传感技术股份有限公司 氧化敏感性材料的集成催化保护
WO2013136044A2 (en) 2012-03-15 2013-09-19 Lightship Medical Limited Sensor
US9017622B2 (en) * 2012-04-10 2015-04-28 Lightship Medical Limited Calibrator for a sensor
US11109779B2 (en) 2012-12-28 2021-09-07 Senseonics, Incorporated Chemical modification of analyte permeable membrane for enhanced oxidative stability
CN105628756B (zh) * 2015-12-30 2018-09-21 南京工业大学 一种血液同步分离与传感膜的制备方法
CA3125326A1 (en) 2018-12-28 2020-07-02 Dexcom, Inc. Analyte sensor with impedance determination
CN110346341A (zh) * 2019-08-08 2019-10-18 生态环境部华南环境科学研究所 一种活性氧含量自动检测系统
EP4217492A4 (en) 2020-09-24 2024-03-27 University of Cincinnati Solute-phase electrochemical aptamer sensors for improved longevity and sensitivity
US12186076B2 (en) 2021-02-09 2025-01-07 Medtronic, Inc. Optical based glucose sensor

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63291596A (ja) * 1987-05-22 1988-11-29 Meidensha Electric Mfg Co Ltd 生体試料中のグルコ−スの測定方法
US6387672B1 (en) 2000-12-04 2002-05-14 Beckman Coulter, Inc. Photo-induced electron transfer fluorescent sensor molecules
SE0200269D0 (sv) * 2002-01-31 2002-01-31 Ellem Bioteknik Ab Material for implantation
AU2003245862A1 (en) 2002-07-12 2004-02-02 Novo Nordisk A/S Minimising calibration problems of in vivo glucose sensors
US7761130B2 (en) * 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8165651B2 (en) * 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
JP2005315871A (ja) * 2004-03-31 2005-11-10 Terumo Corp 体内物質測定用構成物、体内物質測定用構成物の製造方法、および埋込型物質センサー
US7450980B2 (en) 2004-03-31 2008-11-11 Terumo Kabushiki Kaisha Intracorporeal substance measuring assembly
US8541146B2 (en) * 2005-01-12 2013-09-24 Toyota Motor Engineering & Manufacturing North America, Inc. Photocatalytic methods for preparation of electrocatalyst materials
ITFI20050002A1 (it) * 2005-01-11 2006-07-12 Acta Spa Assemblati mambrana-elettrodi per celle a combustibile, loro fabbricazione ed uso e celle a combustibile che le contegono
US20070014726A1 (en) 2005-07-18 2007-01-18 Sensors For Medicine And Science Oxidation-resistant indicator macromolecule
US20070154466A1 (en) 2005-12-30 2007-07-05 Jan Weber Internal medical devices containing peroxide-converting catalysts
JP5517624B2 (ja) 2006-11-30 2014-06-11 センセオニクス，インコーポレーテッド 耐酸化性指示薬分子
DK2989975T3 (en) 2007-02-06 2018-09-24 Medtronic Minimed Inc OPTICAL SYSTEMS AND PROCEDURES FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION
US8088097B2 (en) 2007-11-21 2012-01-03 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
EP2162057A1 (en) 2007-05-10 2010-03-17 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
GB0715590D0 (en) 2007-08-09 2007-09-19 Glysure Ltd Sensing apparatus
GB0906318D0 (en) 2009-04-09 2009-05-20 Glysure Ltd Fluorophore and fluorescent sensor compound containing same
US20100298674A1 (en) 2009-04-21 2010-11-25 Sensors For Medicine & Science, Inc. Protective shell for an in vivo sensor made from resorbable polymer
US20120034550A1 (en) * 2009-04-21 2012-02-09 Washington University In St. Louis Palladium-Platinum Nanostructures And Methods For Their Preparation
MY186820A (en) 2009-04-21 2021-08-23 Tetrasun Inc High-efficiency solar cell structures and methods of manufacture
US8940544B2 (en) * 2010-02-08 2015-01-27 Medtronic Minimed, Inc. Antioxidant protection of a chemical sensor
EP2537034B1 (en) * 2010-02-16 2019-01-02 Lightship Medical Limited Barrier layer for glucose sensor
JP2013519894A (ja) 2010-02-19 2013-05-30 ライトシップ メディカル リミテッド 光ファイバーセンサ用の指示システム
WO2011113020A1 (en) 2010-03-11 2011-09-15 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction
US9970940B2 (en) * 2011-08-17 2018-05-15 Lightship Medical Limited Barrier layer for glucose sensor
WO2013136044A2 (en) * 2012-03-15 2013-09-19 Lightship Medical Limited Sensor

Also Published As

Publication number Publication date
EP2825095A2 (en) 2015-01-21
US9476886B2 (en) 2016-10-25
CN104168827A (zh) 2014-11-26
US20170010274A1 (en) 2017-01-12
US20140234982A1 (en) 2014-08-21
AU2013234126A1 (en) 2014-09-25
CA2867092A1 (en) 2013-09-19
US9797909B2 (en) 2017-10-24
WO2013136044A3 (en) 2013-12-27
CA3095821A1 (en) 2013-09-19
JP2015509803A (ja) 2015-04-02
US8940542B2 (en) 2015-01-27
US20150219663A1 (en) 2015-08-06
IN2014DN07535A (enExample) 2015-04-24
WO2013136044A2 (en) 2013-09-19
CA3095821C (en) 2023-03-14

Similar Documents

Publication Publication Date Title
CA3095821C (en) Sensor
Du et al. Electrospun nanofiber-based glucose sensors for glucose detection
Shim et al. Au decorated core-shell structured Au@ Pt for the glucose oxidation reaction
Shrestha et al. Fabrication of flexible glucose sensor based on heterostructure ZnO nanosheets decorated PU/Chitosan-PANI hybrid nanofiber
WO2009097357A1 (en) Analyte sensors having nanostructured electrodes and methods for making and using them
Chatard et al. Microelectrode biosensors for in vivo analysis of brain interstitial fluid
Arivazhagan et al. Nanostructured transition metal sulfide-based glucose and lactic acid electrochemical sensors for clinical applications
EP2744909B1 (en) Method for preparing a barrier layer for a glucose sensor
Deng et al. Effect of protein adsorption on bioelectrochemistry of electrospun core-shell MWCNTs/gelatin-Hb nanobelts on electrode surface
Huang et al. Functionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H2O2 in Cancer Cells
Ma et al. Coupling metal organic frameworks nanozyme with carbon nanotubes on the gradient porous hollow fiber membrane for nonenzymatic electrochemical H2O2 detection
Bao et al. In situ detection of released H2O2 from living cells by carbon cloth-supported graphene/Au–Pt nanoparticles
Njagi et al. A sensitive electrochemical sensor based on chitosan and electropolymerized Meldola blue for monitoring NO in brain slices
WO2015061371A1 (en) Compositions and methods for measurement of analytes
CN116789106A (zh) 一种三联吡啶钌掺杂的介孔碳纳米球及其制备方法和应用
Palod et al. Facile synthesis of high density polypyrrole nanofiber network with controllable diameters by one step template free electropolymerization for biosensing applications
Shrestha et al. Durable, Breathable, and Flexible Sensor Based on Vapor‐Phase Polymerized PANI‐Coated PUC‐CoNi‐LDH@ PANI Composite for Continuous Sweat Glucose Monitoring
Zhang et al. In Vivo dopamine biosensor based on copper (I) sulfide functionalized reduced graphene oxide decorated microelectrodes
EP2135843B1 (en) Nanostructured composite material and biosensor comprising it
Batayneh et al. Stretchable and Strain‐Tolerant Gold‐Coated Fibrous Biosensor for Superoxide Anion Monitoring
Frost et al. In vivo sensors for continuous monitoring of blood gases, glucose, and lactate: biocompatibility challenges and potential solutions
CN121830847A (zh) DNA-cho/M@ZIF-8/CFME电极及其制备方法与应用
Majdinasab for Glucose Monitoring
Baldini Chemical and biochemical optical fibre sensing for invasive and intracellular application: Past, present and future
Wang A Membrane Biosensor for the Detection of Lactate in Body Fluids

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190220

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250123

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250123

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250123

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R11-R127 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER RECORDAL REQUEST OR RESPONSE

Effective date: 20251105

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20251105

R14 Transfer of ownership recorded

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20251106

R00 Party data change recorded

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R00-R125 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: COMMON REPRESENTATIVE APPOINTED

Effective date: 20260114

R14 Transfer of ownership recorded

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20260114

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20260114

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260123

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260123

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260729