CA2866145A1 - Inhibition of adaptor associated kinase 1 for the treatment of pain - Google Patents
Inhibition of adaptor associated kinase 1 for the treatment of pain Download PDFInfo
- Publication number
- CA2866145A1 CA2866145A1 CA2866145A CA2866145A CA2866145A1 CA 2866145 A1 CA2866145 A1 CA 2866145A1 CA 2866145 A CA2866145 A CA 2866145A CA 2866145 A CA2866145 A CA 2866145A CA 2866145 A1 CA2866145 A1 CA 2866145A1
- Authority
- CA
- Canada
- Prior art keywords
- pyridazin
- imidazo
- amino
- methyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 30
- 102100038079 AP2-associated protein kinase 1 Human genes 0.000 title claims abstract description 6
- 101710148635 AP2-associated protein kinase 1 Proteins 0.000 title claims abstract description 6
- 238000011282 treatment Methods 0.000 title abstract description 9
- 230000005764 inhibitory process Effects 0.000 title description 8
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 8
- 208000004296 neuralgia Diseases 0.000 claims description 8
- 208000021722 neuropathic pain Diseases 0.000 claims description 8
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 4
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 3
- 208000001640 Fibromyalgia Diseases 0.000 claims description 3
- 239000003112 inhibitor Substances 0.000 abstract description 11
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- 125000001183 hydrocarbyl group Chemical group 0.000 description 76
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 52
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- 125000004093 cyano group Chemical group *C#N 0.000 description 49
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 23
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Classifications
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US61/608,849 | 2012-03-09 | ||
| PCT/US2013/029258 WO2013134336A2 (en) | 2012-03-09 | 2013-03-06 | Inhibition of adaptor associated kinase 1 for the treatment of pain |
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| PL (1) | PL2822555T3 (enExample) |
| PT (1) | PT2822555T (enExample) |
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| PL2834243T3 (pl) * | 2012-03-09 | 2018-09-28 | Lexicon Pharmaceuticals, Inc. | Związki na bazie pirazolo[1,5-a]pirymidyny, zawierające je kompozycje i sposoby ich zastosowania |
| SG11201405563VA (en) * | 2012-03-09 | 2014-10-30 | Lexicon Pharmaceuticals Inc | Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| EP2958924B1 (en) | 2013-02-22 | 2016-12-28 | Bristol-Myers Squibb Company | 5h-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (aak1) |
| WO2014175370A1 (ja) * | 2013-04-25 | 2014-10-30 | 塩野義製薬株式会社 | ピロリジン誘導体およびそれらを含有する医薬組成物 |
| CN105492444B (zh) * | 2013-07-02 | 2018-09-07 | 百时美施贵宝公司 | 作为rock抑制剂的三环吡啶-甲酰胺衍生物 |
| EP3019475A1 (en) | 2013-07-08 | 2016-05-18 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| TW201542550A (zh) * | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法 |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| CN105683196B (zh) * | 2013-09-11 | 2018-12-21 | 百时美施贵宝公司 | 基于芳基醚的激酶抑制剂 |
| CN105979950A (zh) * | 2013-10-11 | 2016-09-28 | 百时美施贵宝公司 | 吡咯并三嗪激酶抑制剂 |
| JP6441947B2 (ja) * | 2014-01-31 | 2018-12-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | キノリンを基にしたキナーゼ阻害剤 |
| TW201620911A (zh) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法 |
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| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
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| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US20070049591A1 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| CA2667962A1 (en) * | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
| JP5492194B2 (ja) * | 2008-05-13 | 2014-05-14 | アイアールエム・リミテッド・ライアビリティ・カンパニー | キナーゼ阻害剤としての縮合窒素含有ヘテロ環およびその組成物 |
| WO2010028005A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
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2013
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- 2013-03-06 PL PL13709722T patent/PL2822555T3/pl unknown
- 2013-03-06 PT PT137097226T patent/PT2822555T/pt unknown
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- 2013-03-06 AU AU2013230066A patent/AU2013230066A1/en not_active Abandoned
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- 2013-03-06 HU HUE13709722A patent/HUE036040T2/hu unknown
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- 2013-03-06 US US13/786,575 patent/US20140080834A1/en not_active Abandoned
- 2013-03-06 CN CN201380012478.XA patent/CN104220071A/zh active Pending
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| US20190134037A1 (en) | 2019-05-09 |
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| ES2657061T3 (es) | 2018-03-01 |
| DK2822555T3 (en) | 2018-02-05 |
| US20150164899A1 (en) | 2015-06-18 |
| PL2822555T3 (pl) | 2018-04-30 |
| NO2935475T3 (enExample) | 2017-12-16 |
| EP2822555B1 (en) | 2017-11-08 |
| US20140080834A1 (en) | 2014-03-20 |
| WO2013134336A2 (en) | 2013-09-12 |
| AU2013230066A1 (en) | 2014-09-25 |
| PT2822555T (pt) | 2018-01-25 |
| US20160206619A1 (en) | 2016-07-21 |
| CN104220071A (zh) | 2014-12-17 |
| EP2822555A2 (en) | 2015-01-14 |
| WO2013134336A3 (en) | 2014-03-06 |
| HUE036040T2 (hu) | 2018-06-28 |
| EP3235499A2 (en) | 2017-10-25 |
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