CA2855818A1 - A method of treating lung cancer having an fgfr1 gene amplification or fgfr1 overexpression - Google Patents
A method of treating lung cancer having an fgfr1 gene amplification or fgfr1 overexpression Download PDFInfo
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- CA2855818A1 CA2855818A1 CA2855818A CA2855818A CA2855818A1 CA 2855818 A1 CA2855818 A1 CA 2855818A1 CA 2855818 A CA2855818 A CA 2855818A CA 2855818 A CA2855818 A CA 2855818A CA 2855818 A1 CA2855818 A1 CA 2855818A1
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- fgfr1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| RU2509774C2 (ru) | 2008-08-04 | 2014-03-20 | Файв Прайм Терапьютикс, Инк. | Мутеины кислотной зоны внеклеточного домена рецептора фактора роста фибробластов |
| US8614183B2 (en) | 2009-11-13 | 2013-12-24 | Five Prime Therapeutics, Inc. | Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2 |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| CN107823630A (zh) | 2011-11-14 | 2018-03-23 | 戊瑞治疗有限公司 | 治疗癌症的方法 |
| TWI718086B (zh) | 2013-01-07 | 2021-02-11 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| AU2014259956A1 (en) * | 2013-05-01 | 2015-11-12 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
| CN107847564B (zh) * | 2015-05-12 | 2021-11-09 | 远东超级实验室有限公司 | 鉴定对肿瘤具有直接抑制作用的干扰素的方法及其用途 |
| CN107794293A (zh) * | 2016-08-31 | 2018-03-13 | 安诺优达基因科技(北京)有限公司 | 一种基因捕获试剂盒 |
| CN109609640A (zh) * | 2019-01-14 | 2019-04-12 | 中国科学院上海高等研究院 | Etv4的用途 |
| AU2019460208A1 (en) * | 2019-08-05 | 2022-03-17 | Genex Health Co., Ltd | Method for culturing primary cells of lung cancer solid tumor and primary tumor cells of lung cancer pleural effusion, and supporting reagent |
| CN111735950B (zh) * | 2020-07-17 | 2023-07-21 | 北京信诺卫康科技有限公司 | Fgf18和ca125联合用作早期卵巢癌生物标志物以及试剂盒 |
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| DE69033109T2 (de) | 1989-07-06 | 1999-11-18 | The Regents Of The University Of California, Oakland | Rezeptoren für fibroblasten-wachstumsfaktoren |
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| US5474914A (en) | 1992-07-29 | 1995-12-12 | Chiron Corporation | Method of producing secreted CMV glycoprotein H |
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| DE19802377A1 (de) | 1998-01-22 | 1999-08-19 | Max Planck Gesellschaft | Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs |
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| US7135311B1 (en) | 1999-05-05 | 2006-11-14 | Institut Curie | Means for detecting and treating pathologies linked to FGFR3 |
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| US20050187150A1 (en) | 2001-10-31 | 2005-08-25 | New York University | Structure-based design and synthesis of FGF inhibitors and FGF modulator compounds |
| PL376381A1 (en) | 2002-07-15 | 2005-12-27 | Immunex Corporation | Methods and media for controlling sialylation of proteins produced by mammalian cells |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| IL156495A0 (en) | 2003-06-17 | 2004-01-04 | Prochon Biotech Ltd | Use of fgfr3 antagonists for treating t cell mediated diseases |
| CA2550245A1 (en) | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| US20060286102A1 (en) | 2004-05-14 | 2006-12-21 | Pei Jin | Cell surface receptor isoforms and methods of identifying and using the same |
| WO2005115363A2 (en) | 2004-05-25 | 2005-12-08 | Yale University | Method for treating skeletal disorders resulting from fgfr malfunction |
| WO2006081430A2 (en) | 2005-01-27 | 2006-08-03 | Five Prime Therapeutics, Inc. | Leader sequences for directing secretion of polypeptides and methods for production thereof |
| US20060234347A1 (en) | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| EP2083081A1 (en) | 2005-07-22 | 2009-07-29 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| WO2007059574A1 (en) | 2005-11-23 | 2007-05-31 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
| TWI388568B (zh) | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗ｆｇｆ１９抗體及其使用方法 |
| JP2009536834A (ja) | 2006-05-12 | 2009-10-22 | ジェネンテック・インコーポレーテッド | 癌の診断及び治療のための方法及び組成物 |
| CL2007003411A1 (es) | 2006-11-28 | 2008-07-04 | Centelion | Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu |
| WO2008103755A1 (en) | 2007-02-20 | 2008-08-28 | Mayo Foundation For Medical Education And Research | Treating cancer with viral nucleic acid |
| JP2010525301A (ja) | 2007-03-23 | 2010-07-22 | ザ・トランスレーショナル・ジェノミクス・リサーチ・インスティチュート | 子宮内膜癌および前癌の診断、分類および治療の方法 |
| WO2008133873A2 (en) | 2007-04-25 | 2008-11-06 | Aveo Pharmaceuticals, Inc. | Fgf-binding fusion proteins |
| CL2008003449A1 (es) | 2007-11-21 | 2010-02-19 | Imclone Llc | Anticuerpo o fragmentos del mismo contra el receptor de proteína estimulante de macrófagos/ron; composición farmacéutica que lo comprende; uso para inhibir angiogénesis, crecimiento tumoral, proliferación, migración e invasión de células tumorales, activación de ron o fosforilación de mapk y/o akt; y uso para tratar cáncer. |
| MX342553B (es) * | 2008-04-29 | 2016-10-04 | Novartis Ag | Metodos para monitorear la modulacion de la actividad de cinasa del receptor del factor de crecimiento de fibroblastos y uso de dichos metodos. |
| RU2509774C2 (ru) | 2008-08-04 | 2014-03-20 | Файв Прайм Терапьютикс, Инк. | Мутеины кислотной зоны внеклеточного домена рецептора фактора роста фибробластов |
| EP2478003A4 (en) | 2009-09-15 | 2013-05-29 | Five Prime Therapeutics Inc | HAIR GROWTH METHODS USING THE EXTRACELLULAR DOMAINS OF FGFR4 |
| US8614183B2 (en) | 2009-11-13 | 2013-12-24 | Five Prime Therapeutics, Inc. | Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2 |
| EP2512501A4 (en) | 2009-12-17 | 2014-01-01 | Five Prime Therapeutics Inc | METHODS FOR PROMOTING HAIR GROWTH USING FGFR3 EXTRACELLULAR DOMAINS |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| NZ703786A (en) | 2010-11-15 | 2016-08-26 | Five Prime Therapeutics Inc | Fgfr1 extracellular domain combination therapies |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| IT1404531B1 (it) | 2011-02-24 | 2013-11-22 | Sisvel Technology Srl | Procedimento e sistema di localizzazione indoor per terminali mobili in una rete di telecomunicazione mobile cellulare e relativo terminale mobile. |
| SG192962A1 (en) | 2011-03-17 | 2013-09-30 | Novartis Ag | Fgfr and ligands thereof as biomarkers for breast cancer in hr positive subjects |
| EP2723391B1 (en) | 2011-06-24 | 2018-06-13 | University of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| CN107823630A (zh) | 2011-11-14 | 2018-03-23 | 戊瑞治疗有限公司 | 治疗癌症的方法 |
| AU2014259956A1 (en) | 2013-05-01 | 2015-11-12 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
-
2012
- 2012-11-13 CN CN201711171931.8A patent/CN107823630A/zh active Pending
- 2012-11-13 CN CN201280066268.4A patent/CN104168915A/zh active Pending
- 2012-11-13 WO PCT/US2012/064772 patent/WO2013074492A1/en not_active Ceased
- 2012-11-13 HK HK15102726.0A patent/HK1202240A1/xx unknown
- 2012-11-13 CA CA2855818A patent/CA2855818A1/en not_active Abandoned
- 2012-11-13 EP EP12849489.5A patent/EP2780033B1/en active Active
- 2012-11-13 HK HK15102035.6A patent/HK1201462A1/xx unknown
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- 2012-11-13 AU AU2012318247A patent/AU2012318247B2/en active Active
- 2012-11-13 TW TW101142331A patent/TW201326201A/zh unknown
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- 2012-11-13 JP JP2014541396A patent/JP2015505818A/ja active Pending
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2017
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|---|---|
| HK1201462A1 (en) | 2015-09-04 |
| EP2780033B1 (en) | 2019-05-08 |
| CN107823630A (zh) | 2018-03-23 |
| EP2780033A1 (en) | 2014-09-24 |
| JP6578318B2 (ja) | 2019-09-18 |
| EP2780033A4 (en) | 2015-11-04 |
| US10016484B2 (en) | 2018-07-10 |
| WO2013074492A1 (en) | 2013-05-23 |
| CN104168915A (zh) | 2014-11-26 |
| US20190000920A1 (en) | 2019-01-03 |
| US10537611B2 (en) | 2020-01-21 |
| US20140341900A1 (en) | 2014-11-20 |
| JP2017206506A (ja) | 2017-11-24 |
| JP2015505818A (ja) | 2015-02-26 |
| HK1202240A1 (en) | 2015-09-25 |
| AU2012318247A1 (en) | 2013-05-30 |
| AU2012318247B2 (en) | 2015-12-17 |
| US20130136740A1 (en) | 2013-05-30 |
| TW201326201A (zh) | 2013-07-01 |
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