CA2854805C - Method of predicting breast cancer prognosis - Google Patents

Method of predicting breast cancer prognosis Download PDF

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Publication number
CA2854805C
CA2854805C CA2854805A CA2854805A CA2854805C CA 2854805 C CA2854805 C CA 2854805C CA 2854805 A CA2854805 A CA 2854805A CA 2854805 A CA2854805 A CA 2854805A CA 2854805 C CA2854805 C CA 2854805C
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Prior art keywords
breast cancer
recurrence
likelihood
rna
patient
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CA2854805A
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English (en)
French (fr)
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CA2854805A1 (en
Inventor
Joffre B. Baker
Dominick V. Sinicropi
Robert J. Pelham
Michael Crager
Francois Collin
James C. STEPHANS
Mei-lan LIU
John Morlan
Kunbin Qu
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Genomic Health Inc
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Genomic Health Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G01N33/57515—
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2854805A 2011-11-08 2012-11-02 Method of predicting breast cancer prognosis Active CA2854805C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161557238P 2011-11-08 2011-11-08
US61/557,238 2011-11-08
US201261597426P 2012-02-10 2012-02-10
US61/597,426 2012-02-10
PCT/US2012/063313 WO2013070521A1 (en) 2011-11-08 2012-11-02 Method of predicting breast cancer prognosis

Publications (2)

Publication Number Publication Date
CA2854805A1 CA2854805A1 (en) 2013-05-16
CA2854805C true CA2854805C (en) 2021-04-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2854805A Active CA2854805C (en) 2011-11-08 2012-11-02 Method of predicting breast cancer prognosis

Country Status (9)

Country Link
US (4) US20140296085A1 (enExample)
EP (1) EP2776830B1 (enExample)
JP (2) JP6147755B2 (enExample)
AU (1) AU2012336120B2 (enExample)
CA (1) CA2854805C (enExample)
IL (4) IL232445B (enExample)
MX (1) MX357402B (enExample)
SG (2) SG10202010758SA (enExample)
WO (1) WO2013070521A1 (enExample)

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WO2014130444A1 (en) * 2013-02-19 2014-08-28 Genomic Health, Inc. Method of predicting breast cancer prognosis
BR112016005225B1 (pt) * 2013-09-11 2023-11-14 Bio Theranostics, Inc Métodos para avaliar câncer de mama em um indivíduo
WO2015066068A1 (en) * 2013-10-29 2015-05-07 Genomic Health, Inc. Methods of incorporation of transcript chromosomal locus information for identification of biomarkers of disease recurrence risk
CN105214077B (zh) * 2014-06-03 2019-02-05 浙江阿思科力生物科技有限公司 Usp33在肿瘤中的应用
WO2016094330A2 (en) * 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
CN107111689B (zh) * 2014-12-10 2021-12-07 皇家飞利浦有限公司 用于生成非编码-编码基因共表达网络的方法和系统
ES2887201T3 (es) 2015-09-01 2021-12-22 Eisai R&D Man Co Ltd Variantes de empalme asociadas con mutantes neomórficos de SF3B1
WO2017070581A1 (en) * 2015-10-23 2017-04-27 Novartis Ag Method of deriving a value for percent biomarker positivity for selected cells present in a field of view
US11530448B2 (en) 2015-11-13 2022-12-20 Biotheranostics, Inc. Integration of tumor characteristics with breast cancer index
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CN108893537B (zh) * 2018-07-19 2020-10-30 青岛泱深生物医药有限公司 C7orf70及其应用
JP2020028278A (ja) * 2018-08-24 2020-02-27 国立大学法人九州大学 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法
US20220002815A1 (en) * 2018-11-04 2022-01-06 Pfs Genomics, Inc. Methods and genomic classifiers for prognosis of breast cancer and predicting benefit from adjuvant radiotherapy
CN109859801B (zh) * 2019-02-14 2023-09-19 辽宁省肿瘤医院 一种含有七个基因作为生物标志物预测肺鳞癌预后的模型及建立方法
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
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WO2021216990A1 (en) * 2020-04-23 2021-10-28 Board Of Regents, The University Of Texas System Methods and compositions related to full-length excised intron rnas (flexi rnas)
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RU2763839C1 (ru) * 2021-04-27 2022-01-11 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Петрова" Минздрава России) Способ многофакторного прогноза рака молочной железы
CN113667749A (zh) * 2021-08-03 2021-11-19 广东省人民医院 四个关键基因组合评估乳腺癌风险的诊断试剂盒
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Publication number Publication date
SG11201402042PA (en) 2014-06-27
AU2012336120A1 (en) 2014-05-29
EP2776830A1 (en) 2014-09-17
HK1201329A1 (en) 2015-08-28
CA2854805A1 (en) 2013-05-16
IL276488B (en) 2021-04-29
WO2013070521A1 (en) 2013-05-16
IL232445A0 (en) 2014-06-30
US20160222463A1 (en) 2016-08-04
NZ624700A (en) 2016-08-26
JP6147755B2 (ja) 2017-06-14
MX357402B (es) 2018-07-09
SG10202010758SA (en) 2020-11-27
US20190256923A1 (en) 2019-08-22
EP2776830A4 (en) 2015-07-15
EP2776830B1 (en) 2018-05-09
JP2014532428A (ja) 2014-12-08
MX2014005547A (es) 2014-08-29
US20140296085A1 (en) 2014-10-02
JP2017055769A (ja) 2017-03-23
IL232445B (en) 2018-10-31
US20200263257A1 (en) 2020-08-20
AU2012336120B2 (en) 2017-10-26
IL261708A (en) 2018-10-31
IL276488A (en) 2020-09-30
IL265136B (en) 2020-08-31

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