CA2854550C - .alpha.v.beta.6 peptide ligands and their uses - Google Patents

.alpha.v.beta.6 peptide ligands and their uses Download PDF

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Publication number
CA2854550C
CA2854550C CA2854550A CA2854550A CA2854550C CA 2854550 C CA2854550 C CA 2854550C CA 2854550 A CA2854550 A CA 2854550A CA 2854550 A CA2854550 A CA 2854550A CA 2854550 C CA2854550 C CA 2854550C
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CA
Canada
Prior art keywords
peptide
peptides
avp6
binding
helix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2854550A
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English (en)
French (fr)
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CA2854550A1 (en
Inventor
Mark J. Howard
Danielle Dicara
John F. Marshall
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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Publication of CA2854550A1 publication Critical patent/CA2854550A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2854550A 2005-10-03 2006-10-03 .alpha.v.beta.6 peptide ligands and their uses Active CA2854550C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0520068.8 2005-10-03
GB0520068A GB0520068D0 (en) 2005-10-03 2005-10-03 av peptide ligand
CA2624618A CA2624618C (en) 2005-10-03 2006-10-03 Av.beta.6 peptide ligands and their uses

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2624618A Division CA2624618C (en) 2005-10-03 2006-10-03 Av.beta.6 peptide ligands and their uses

Publications (2)

Publication Number Publication Date
CA2854550A1 CA2854550A1 (en) 2007-04-12
CA2854550C true CA2854550C (en) 2020-04-14

Family

ID=35395162

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2624618A Active CA2624618C (en) 2005-10-03 2006-10-03 Av.beta.6 peptide ligands and their uses
CA2854550A Active CA2854550C (en) 2005-10-03 2006-10-03 .alpha.v.beta.6 peptide ligands and their uses

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2624618A Active CA2624618C (en) 2005-10-03 2006-10-03 Av.beta.6 peptide ligands and their uses

Country Status (7)

Country Link
US (3) US8383593B2 (enExample)
EP (1) EP1957522B1 (enExample)
JP (1) JP5449774B2 (enExample)
CA (2) CA2624618C (enExample)
ES (1) ES2638439T3 (enExample)
GB (1) GB0520068D0 (enExample)
WO (1) WO2007039728A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0520068D0 (en) 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
JP5362563B2 (ja) 2006-08-03 2013-12-11 アストラゼネカ・アクチエボラーグ αVβ6に対する抗体およびその使用
GB0718843D0 (en) 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
JP2013520173A (ja) * 2010-02-18 2013-06-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア インテグリンαvβ8中和抗体
WO2013025261A2 (en) * 2011-04-06 2013-02-21 Georgia Tech Research Corporation Fluorogenic peptide probes and assays
WO2013078250A2 (en) 2011-11-22 2013-05-30 The Board Of Trustees Of The Leland Stanford Junior University Cystine knot peptides that bind alpha-v-beta-6 integrin
US9403877B2 (en) 2012-01-24 2016-08-02 Inter-K Pty Limited Peptide agents for cancer therapy
US9027086B2 (en) * 2013-02-01 2015-05-05 Vidder, Inc. Securing organizational computing assets over a network using virtual domains
GB201311031D0 (en) * 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
JP6789823B2 (ja) * 2014-04-15 2020-11-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 両末端peg化インテグリン結合性ペプチドおよびその使用方法
GB201513540D0 (en) 2015-07-31 2015-09-16 King S College London Therapeutic agents
CA3027364A1 (en) 2016-06-13 2017-12-21 The Regents Of The University Of California Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
BR112018076184A2 (pt) * 2016-06-16 2019-03-26 The University Of Liverpool composição sólida, composição farmacêutica ou veterinária na forma injetável, formulação intramuscularmente injetável, formulação subcutaneamente injetável, dispersão aquosa, dispersão oleosa, processos para preparar uma composição sólida, uma dispersão aquosa e uma dispersão oleosa, métodos para tratar e/ou prevenir uma infecção parasítica ou fúngica e para prevenir malária, e, kit para preparação de uma formulação líquida estéril de nanopartículas de atovaquona para injeção.
CA3036232C (en) 2016-09-29 2025-11-18 The Regents Of The University Of California Neutralizing antibodies directed against the Integrin Alpha V Beta 8 complex for immunotherapy
CN109952376B (zh) * 2016-11-01 2023-09-05 箭头药业股份有限公司 αvβ6整联蛋白配体及其应用
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
IL274300B2 (en) 2017-11-01 2024-09-01 Arrowhead Pharmaceuticals Inc Alpha v beta 6 integrin ligands, compositions comprising same and uses thereof
GB201802539D0 (en) * 2018-02-16 2018-04-04 Univ College Cardiff Consultants Ltd Modified adenoviruses
EP3846858A4 (en) * 2018-09-07 2022-10-19 The Regents of the University of California Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
US20220348609A1 (en) * 2019-10-25 2022-11-03 University Of Washington Computational design of alpha(v) beta (6) integrin binding proteins
US20220402980A1 (en) * 2019-11-15 2022-12-22 Ospedale San Raffaele S.R.L. Chromogranin a-derived peptides and uses thereof
KR20230167082A (ko) 2021-04-08 2023-12-07 애로우헤드 파마슈티컬스 인코포레이티드 진행성 당화 최종 산물에 대한 수용체의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법
WO2022221144A1 (en) * 2021-04-12 2022-10-20 University Of Washington Engineered peptides for αvβ6 integrin binding and related methods of use and synthesis
CN115010949B (zh) * 2022-07-12 2024-02-13 华熙生物科技股份有限公司 促渗物、护肤品组合物以及化妆品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301928D0 (en) 1983-01-24 1983-02-23 Nicholson B H Process for producing polypeptides
JPS60103596A (ja) * 1983-11-11 1985-06-07 Toshiba Corp サンプル・ホ−ルド回路
AUPM411994A0 (en) * 1994-02-25 1994-03-24 Deakin Research Limited Epitopes
JP2002533064A (ja) * 1998-12-19 2002-10-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング インテグリンαvβ6阻害剤
DE19929410A1 (de) * 1999-06-26 2000-12-28 Merck Patent Gmbh Inhibitoren des Integrins avß6
DE19933173A1 (de) * 1999-07-15 2001-01-18 Merck Patent Gmbh Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶
AU2001258638A1 (en) * 2000-05-26 2001-12-03 Glaxo Group Limited Methods for identifying modulators of the interaction between lap (latency associated peptide) and intergrin alpha.v.beta.3 and medical use thereof
US20030031648A1 (en) * 2000-11-28 2003-02-13 Virogene Ltd. Vectors for expressing heterologous peptides at the amino-terminus of potyvirus coat protein, methods for use thereof, plants infected with same and methods of vaccination using same
GB0520068D0 (en) 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand

Also Published As

Publication number Publication date
US8383593B2 (en) 2013-02-26
CA2624618A1 (en) 2007-04-12
US20090123370A1 (en) 2009-05-14
JP5449774B2 (ja) 2014-03-19
EP1957522B1 (en) 2017-07-12
JP2009509562A (ja) 2009-03-12
ES2638439T3 (es) 2017-10-20
US20150125392A1 (en) 2015-05-07
US9650416B2 (en) 2017-05-16
US20130149248A1 (en) 2013-06-13
CA2854550A1 (en) 2007-04-12
GB0520068D0 (en) 2005-11-09
WO2007039728A3 (en) 2007-09-20
US8927501B2 (en) 2015-01-06
EP1957522A2 (en) 2008-08-20
CA2624618C (en) 2016-03-29
WO2007039728A2 (en) 2007-04-12

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EEER Examination request

Effective date: 20140617

EEER Examination request

Effective date: 20140617