CA2854422A1 - Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment - Google Patents

Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment Download PDF

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Publication number
CA2854422A1
CA2854422A1 CA2854422A CA2854422A CA2854422A1 CA 2854422 A1 CA2854422 A1 CA 2854422A1 CA 2854422 A CA2854422 A CA 2854422A CA 2854422 A CA2854422 A CA 2854422A CA 2854422 A1 CA2854422 A1 CA 2854422A1
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CA
Canada
Prior art keywords
lipid
cer
compared
sample
concentration ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2854422A
Other languages
English (en)
French (fr)
Inventor
Reijo Laaksonen
Kim Ekroos
Reini Hurme
Minna Janis
Riikka Katainen
Kirill Tarasov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zora Biosciences Oy
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Zora Biosciences Oy
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Publication date
Application filed by Zora Biosciences Oy filed Critical Zora Biosciences Oy
Publication of CA2854422A1 publication Critical patent/CA2854422A1/en
Abandoned legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00Assays, e.g. immunoassays or enzyme assays, involving lipids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/324Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/325Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2854422A 2011-11-08 2012-11-07 Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment Abandoned CA2854422A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161556915P 2011-11-08 2011-11-08
EP11188325.2A EP2592422A1 (en) 2011-11-08 2011-11-08 Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment
EP11188325.2 2011-11-08
US61/556,915 2011-11-08
PCT/EP2012/071973 WO2013068374A2 (en) 2011-11-08 2012-11-07 Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment

Publications (1)

Publication Number Publication Date
CA2854422A1 true CA2854422A1 (en) 2013-05-16

Family

ID=45033776

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2854422A Abandoned CA2854422A1 (en) 2011-11-08 2012-11-07 Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment

Country Status (7)

Country Link
US (3) US9052327B2 (cg-RX-API-DMAC7.html)
EP (2) EP2592422A1 (cg-RX-API-DMAC7.html)
JP (1) JP6388284B2 (cg-RX-API-DMAC7.html)
CN (1) CN104024860B (cg-RX-API-DMAC7.html)
CA (1) CA2854422A1 (cg-RX-API-DMAC7.html)
HK (1) HK1202154A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013068374A2 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9806270B2 (en) 2011-03-25 2017-10-31 Udc Ireland Limited 4H-imidazo[1,2-a]imidazoles for electronic applications
EP2592423A1 (en) 2011-11-08 2013-05-15 Zora Biosciences OY Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment
CN108299439B (zh) 2011-11-10 2021-02-09 Udc 爱尔兰有限责任公司 用于电子应用的4H-咪唑并[1,2-a]咪唑
ES2552371T3 (es) * 2012-05-25 2015-11-27 Zora Biosciences Oy Biomarcadores sensibles, eficaces e inocuos, para la inhibición de la Proproteína Convertasa Subtilisina/Kexina de tipo 9 (PCSK9)
JP6231561B2 (ja) 2012-07-10 2017-11-15 ユー・ディー・シー アイルランド リミテッド 電子用途のためのベンズイミダゾ[1,2−a]ベンズイミダゾール誘導体
NZ724790A (en) 2014-04-10 2022-07-29 MEP Equine Solutions LLC Method for the quantification of parasite eggs in feces
US9347960B2 (en) 2014-06-16 2016-05-24 Zora Biosciences, Oy Ceramides and their use in diagnosing CVD
WO2016100549A2 (en) * 2014-12-16 2016-06-23 Washington University Ceramides for evaluating risk of cardiovascular disease
WO2017097852A2 (en) 2015-12-07 2017-06-15 Zora Biosciences Oy Use of ceramides and lpls in diagnosing cvd
CN105486773A (zh) * 2015-12-25 2016-04-13 齐炼文 用于诊断冠心病的代谢标志物
CN105424841B (zh) * 2015-12-25 2017-11-03 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
CN105628809B (zh) * 2015-12-25 2018-04-03 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
KR102003309B1 (ko) * 2016-12-05 2019-07-25 한국과학기술연구원 대사체 및 임상지표를 활용한 관상동맥 심장질환 진단용 키트 및 기초 정보 제공 방법
CN107144648B (zh) * 2017-04-26 2019-11-22 苏州海科医药技术有限公司 检测人血浆中匹伐他汀的液相色谱-串联质谱方法
CN107014942A (zh) * 2017-05-05 2017-08-04 北京骐骥生物技术有限公司 利用脂质生物标志物预测糖尿病冠心病的方法
WO2019119049A1 (en) * 2017-12-20 2019-06-27 Baker Heart and Diabetes Institute Method of predicting drug therapeutic responder status and methods of treatment
US12441815B2 (en) 2018-11-02 2025-10-14 The Regents Of The University Of California Compositions and methods for diagnosis of cardiovascular disease
WO2020112149A1 (en) * 2018-12-01 2020-06-04 Binhai Industrial Technology Research Institute Of Zhejiang University Methods and compositions for the assessment of acute myocardial infarction (ami)
EP3891509A1 (en) 2018-12-06 2021-10-13 Zora Biosciences OY Biomarkers for cardiovascular events
CN109828076B (zh) * 2019-04-11 2020-07-21 江南大学 一种高效薄层色谱联用生物发光法筛查贝特类降脂化学药掺伪的方法
CN112630344B (zh) * 2020-12-08 2021-12-14 河北医科大学第二医院 代谢标志物在脑梗死中的用途
CN113533754A (zh) * 2021-07-12 2021-10-22 北京市心肺血管疾病研究所 神经酰胺在制备用于评估高血压患者发生不良事件风险的试剂盒中的应用
CN113567583B (zh) * 2021-07-22 2022-06-07 江南大学 应用固相萃取-超临界流体色谱-质谱法检测乳中极性脂的方法
CN116087485B (zh) * 2021-11-08 2023-10-20 中国医学科学院阜外医院 糖尿病患者早期预测心血管疾病(cvd)的生物标志物及其用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE489633T1 (de) * 1997-06-10 2010-12-15 Lpath Inc Verfahren zum frühzeitigen nachweis herzerkrankungen
WO2004038381A2 (en) 2002-10-25 2004-05-06 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7972802B2 (en) 2005-10-31 2011-07-05 University Of Washington Lipoprotein-associated markers for cardiovascular disease
US8137977B2 (en) * 2006-04-24 2012-03-20 Children's Hospital & Research Center At Oakland Lipidomic approaches to determining drug response phenotypes in cardiovascular disease
DE102006034153B4 (de) 2006-07-24 2018-02-08 Magna powertrain gmbh & co kg Getriebe
EP2153236A1 (en) 2007-06-07 2010-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for assessing the risk of a cardiovascular disease and for diagnosing dyslipidemia
EP2048243A1 (en) 2007-09-24 2009-04-15 sanofi-aventis Use of clec1B for the determination of cardiovascular and thrombotic risk
CN101939651A (zh) * 2007-10-10 2011-01-05 保函医药公司 用于检测严重有害的心血管和脑血管事件的方法
US9213030B2 (en) 2008-01-28 2015-12-15 National University Of Singapore Lipid tumour profile
AU2009224114B2 (en) 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
AU2009224113B2 (en) * 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
ES2640900T3 (es) 2008-10-30 2017-11-07 Firalis Biomarcadores
US20110034419A1 (en) * 2009-06-27 2011-02-10 Musc Foundation For Research Development Cardioprotective Drugs and Diagnostics for Assessing Risk of Cardiovascular Disease
ES2768995T3 (es) * 2009-11-17 2020-06-24 Baylor Res Institute 1-desoxigalactonojirimicina para el uso en el tratamiento de una enfermedad cardíaca
WO2011063470A1 (en) 2009-11-27 2011-06-03 Baker Idi Heart And Diabetes Institute Holdings Limited Lipid biomarkers for stable and unstable heart disease
NO2385374T3 (cg-RX-API-DMAC7.html) * 2010-05-05 2014-06-07
EP2583107A2 (en) * 2010-06-20 2013-04-24 Zora Biosciences OY Lipidomic biomarkers for identification of high-risk coronary artery disease patients
EP2400573A1 (de) 2010-06-23 2011-12-28 Bayer MaterialScience AG Elektromechanischer Wandler, Verfahren zu dessen Herstellung und Verwendung desselben
US9664698B2 (en) 2011-04-08 2017-05-30 Zora Biosciences Oy Biomarkers for sensitive detection of statin-induced muscle toxicity
FI20115576A0 (fi) * 2011-06-10 2011-06-10 Teknologian Tutkimuskeskus Vtt Oy Menetelmä Alzheimerin taudin diagnoimiseksi
EP2592423A1 (en) 2011-11-08 2013-05-15 Zora Biosciences OY Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment

Also Published As

Publication number Publication date
JP2014532886A (ja) 2014-12-08
US9459265B2 (en) 2016-10-04
US20150260738A1 (en) 2015-09-17
JP6388284B2 (ja) 2018-09-12
WO2013068374A3 (en) 2013-07-18
HK1202154A1 (en) 2015-09-18
CN104024860B (zh) 2017-06-06
EP2776842A2 (en) 2014-09-17
CN104024860A (zh) 2014-09-03
WO2013068374A2 (en) 2013-05-16
US20140295466A1 (en) 2014-10-02
US20160363602A1 (en) 2016-12-15
EP2592422A1 (en) 2013-05-15
EP2776842B1 (en) 2017-07-12
US9052327B2 (en) 2015-06-09

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Effective date: 20181107