CA2851828A1 - Methods for drug delivery - Google Patents

Methods for drug delivery Download PDF

Info

Publication number
CA2851828A1
CA2851828A1 CA2851828A CA2851828A CA2851828A1 CA 2851828 A1 CA2851828 A1 CA 2851828A1 CA 2851828 A CA2851828 A CA 2851828A CA 2851828 A CA2851828 A CA 2851828A CA 2851828 A1 CA2851828 A1 CA 2851828A1
Authority
CA
Canada
Prior art keywords
agent
solid tissue
agents
needles
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2851828A
Other languages
English (en)
French (fr)
Inventor
Jason Frazier
Richard Klinghoffer
Marc Grenley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Presage Biosciences Inc
Original Assignee
Presage Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Presage Biosciences Inc filed Critical Presage Biosciences Inc
Publication of CA2851828A1 publication Critical patent/CA2851828A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
CA2851828A 2011-10-28 2012-10-26 Methods for drug delivery Abandoned CA2851828A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161553003P 2011-10-28 2011-10-28
US61/553,003 2011-10-28
US201261680847P 2012-08-08 2012-08-08
US61/680,847 2012-08-08
PCT/US2012/062313 WO2013063530A2 (en) 2011-10-28 2012-10-26 Methods for drug delivery

Publications (1)

Publication Number Publication Date
CA2851828A1 true CA2851828A1 (en) 2013-05-02

Family

ID=48168805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2851828A Abandoned CA2851828A1 (en) 2011-10-28 2012-10-26 Methods for drug delivery

Country Status (8)

Country Link
US (3) US20140323907A1 (cg-RX-API-DMAC7.html)
EP (1) EP2771043A4 (cg-RX-API-DMAC7.html)
JP (1) JP2014534864A (cg-RX-API-DMAC7.html)
CN (1) CN104023760A (cg-RX-API-DMAC7.html)
AU (1) AU2012328457A1 (cg-RX-API-DMAC7.html)
CA (1) CA2851828A1 (cg-RX-API-DMAC7.html)
SG (2) SG11201401851UA (cg-RX-API-DMAC7.html)
WO (1) WO2013063530A2 (cg-RX-API-DMAC7.html)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2600901B1 (en) 2010-08-06 2019-03-27 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
AU2012328457A1 (en) 2011-10-28 2014-04-24 Presage Biosciences, Inc. Methods for drug delivery
SMT202200355T1 (it) 2011-12-16 2022-11-18 Modernatx Inc Composizioni di mrna modificato
EP2834260A4 (en) 2012-04-02 2016-08-10 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9358350B2 (en) * 2012-08-06 2016-06-07 Elwha Llc Systems and methods for wearable injection guides
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
EP2974768A4 (en) * 2013-03-12 2017-05-17 Takeda Pharmaceutical Company Limited Micro-needle patch
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
CA2923029A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 低密度リポタンパク質受容体をコードするポリヌクレオチド
US20170049503A1 (en) * 2014-05-15 2017-02-23 Cosman Medical, Inc. Electrosurgical system
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3171895A1 (en) 2014-07-23 2017-05-31 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
WO2016105769A1 (en) * 2014-12-23 2016-06-30 Boston Scientific Scimed, Inc. Marker for detection and confirmation of peripheral lung nodules
CN105012042B (zh) * 2015-06-05 2017-02-01 中国农业科学院兰州兽医研究所 一种活疫苗皮内接种免疫器
EP4349405A3 (en) 2015-10-22 2024-06-19 ModernaTX, Inc. Respiratory virus vaccines
CN108136216B (zh) * 2015-10-23 2021-08-24 诺华股份有限公司 对包含肿瘤组织的样品评分的方法
LT3394093T (lt) 2015-12-23 2022-04-25 Modernatx, Inc. Ox40 ligandus koduojančių polinukleotidų naudojimo būdai
WO2017120612A1 (en) 2016-01-10 2017-07-13 Modernatx, Inc. Therapeutic mrnas encoding anti ctla-4 antibodies
GB201600445D0 (en) * 2016-01-11 2016-02-24 Cairns Intellectual Property Ltd Methods and apparatuses for temperature measurement
EP3419542B1 (en) 2016-02-25 2025-05-14 The General Hospital Corporation Method and apparatus for tightening skin
WO2018028780A1 (en) * 2016-08-10 2018-02-15 Saga Surgical Ab A biopsy needle arrangement
WO2018132430A1 (en) 2017-01-10 2018-07-19 A.T. Still Universiy Fluid infusion system
CN107617140B (zh) * 2017-08-15 2022-06-24 杭州德柯医疗科技有限公司 心室壁注射辅助器械
AU2019223951B2 (en) * 2018-02-20 2020-11-26 Boston Scientific Scimed, Inc. Systems for regulating glucose levels including treating diabetes
IL277195B2 (en) * 2018-03-13 2024-04-01 Vertex Pharma Implantation devices, system, and methods
GB201817838D0 (en) * 2018-10-31 2018-12-19 Imperial Innovations Ltd Apparatus and method for inserting electrode-based probes into biological tissue
AU2020355000A1 (en) 2019-09-23 2022-03-17 Omega Therapeutics, Inc. Compositions and methods for modulating apolipoprotein B (APOB) gene expression
US11987791B2 (en) 2019-09-23 2024-05-21 Omega Therapeutics, Inc. Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression
CN110522969B (zh) * 2019-09-25 2021-08-27 合肥京东方光电科技有限公司 一种注射装置、输液用设备和注射控制方法
CN111134894B (zh) * 2020-01-17 2022-02-22 上海长海医院 一种在体测定犬前列腺组织连续动态游离药物浓度的采样方法
EP4118207A1 (en) 2020-03-11 2023-01-18 Omega Therapeutics, Inc. Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
WO2023283359A2 (en) 2021-07-07 2023-01-12 Omega Therapeutics, Inc. Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
WO2023154908A2 (en) * 2022-02-11 2023-08-17 Board Of Regents, The University Of Texas System Convection-enhanced thermo-chemotherapy catheter system
JP2025508467A (ja) 2022-02-24 2025-03-26 アイオー バイオテック エーピーエス 癌治療のヌクレオチド送達
CN219700059U (zh) * 2022-06-10 2023-09-19 湖州大士医疗科技有限公司 一种夹持杆式多通道夹紧机构
GB202216449D0 (en) 2022-11-04 2022-12-21 Io Biotech Aps TGF-BETA1 vaccine
WO2024243438A2 (en) 2023-05-23 2024-11-28 Omega Therapeutics, Inc. Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
EP4520345A1 (en) 2023-09-06 2025-03-12 Myneo Nv Product

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4256153A (en) 1979-07-09 1981-03-17 Societe Francaise Pour Le Developpement De L'automatisme En Biologie Device for simultaneous transfer of a plurality of liquids
US4966159A (en) 1981-12-14 1990-10-30 Maganias Nicholas H Allergy test strip
US4673565A (en) 1985-05-03 1987-06-16 E. I. Du Pont De Nemours And Company Pharmaceutical compositions containing hollow fine tubular drug delivery systems
US5605160A (en) 1986-04-18 1997-02-25 Fishman; Henry Allergy testing apparatus with variably spaced test testing sites
US5335670A (en) 1986-04-18 1994-08-09 Henry Fishman Allergy testing method and apparatus
BR8707670A (pt) 1986-04-18 1989-08-15 Henry Fishman Aparelho e processo para teste de alergia
US5154181A (en) 1986-04-18 1992-10-13 Henry Fishman Allergy testing method and apparatus
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4865582A (en) 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
JPS63315064A (ja) 1987-06-18 1988-12-22 Kazuki Tsutsumi 注射針
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
JPH01122758U (cg-RX-API-DMAC7.html) 1988-02-17 1989-08-21
US4936835A (en) * 1988-05-26 1990-06-26 Haaga John R Medical needle with bioabsorbable tip
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5104620A (en) 1990-07-30 1992-04-14 Wiley Fred R Disposable allergy skin testing kit
DE69130831T2 (de) 1990-11-21 1999-09-16 Iterex Pharmaceuticals Ltd. Partnership, San Diego Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen
US5885769A (en) 1991-02-14 1999-03-23 Schering Corporation Screening systems
US5474909A (en) * 1992-08-07 1995-12-12 Anticancer, Inc. Noncolorimetric histoculture method for predicting drug response of tumors
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
IL107038A (en) 1992-10-05 1997-04-15 Senetek Plc Medicament injectors and methods for injection using same
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
JPH09506611A (ja) 1993-12-15 1997-06-30 コンビケム,インコーポレイテッド 組合わせライブラリーおよびその使用法
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US8795242B2 (en) 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US5876380A (en) 1994-10-19 1999-03-02 Manganini; Steven J. Portable syringe dispenser system
US5693341A (en) 1995-03-16 1997-12-02 Collagen Corporation Affinity bound collagen matrices for the delivery of biologically active agents
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5538134A (en) 1995-07-25 1996-07-23 Pitesky; Isadore Disposable allergen container and pick apparatus
EP0774464B1 (en) 1995-10-17 2004-07-28 Combichem, Inc. A template for solution phase synthesis of combinatorial libraries
SE9503685D0 (sv) 1995-10-20 1995-10-20 Pharmacia Ab Arrangement in electronically controlled injection devices
AUPN880396A0 (en) 1996-03-21 1996-04-18 Fremantle Hospital Animal model for transplantation
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
US5798035A (en) 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
US5832878A (en) 1997-01-10 1998-11-10 Emory University Apparatus permitting tethered laboratory animals to move freely
US5865766A (en) * 1997-01-10 1999-02-02 Emory University Multichannel, multipurpose sample collection and drug delivery system for laboratory animals
WO1998030254A2 (en) * 1997-01-10 1998-07-16 Emory University Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals
US5846225A (en) 1997-02-19 1998-12-08 Cornell Research Foundation, Inc. Gene transfer therapy delivery device and method
US6953662B2 (en) 1997-08-29 2005-10-11 Human Genome Sciences, Inc. Follistatin-3
US20040033230A1 (en) 1997-12-24 2004-02-19 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US20060015058A1 (en) 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US6286455B1 (en) * 1998-01-12 2001-09-11 Embrex, Inc. Automated in ovo injection apparatus
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6146594A (en) 1999-02-10 2000-11-14 Robbins Scientific Corporation Syringe array with adjustable needle spacing
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
AU758226B2 (en) 1998-07-29 2003-03-20 Texaco Development Corporation Integration of solvent deasphalting and gasification
WO2000006770A1 (en) 1998-07-30 2000-02-10 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6358276B1 (en) 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6330479B1 (en) 1998-12-07 2001-12-11 The Regents Of The University Of California Microwave garment for heating and/or monitoring tissue
ES2242602T3 (es) 1999-01-06 2005-11-16 United States Surgical Corporation Dispositivo de inyeccion para cartografia de tejidos.
US6685913B1 (en) 1999-03-09 2004-02-03 Thomas Jefferson University Lipid soluble radioactive metal chelates for tumor therapy
CA2368611A1 (en) 1999-03-25 2000-09-28 Nicholas F. D'antonio Hypodermic injection system
AU778736B2 (en) 1999-03-25 2004-12-16 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US7030097B1 (en) 1999-07-14 2006-04-18 Cornell Research Foundation, Inc. Controlled nucleic acid delivery systems
WO2001021219A2 (en) * 1999-09-21 2001-03-29 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Imaging of drug accumulation as a guide to antitumor therapy
EP1416980A2 (en) * 1999-12-30 2004-05-12 Redeon, Inc. Stacked microneedle systems
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6428504B1 (en) 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
US6468247B1 (en) 2000-04-21 2002-10-22 Mark Zamoyski Perfusion device for localized drug delivery
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6620403B2 (en) 2000-04-26 2003-09-16 Roman Perez-Soler In vivo chemosensitivity screen for human tumors
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6482187B1 (en) 2000-10-23 2002-11-19 Fred O. Gibbs Animal identification and medication syringe
US6616626B2 (en) 2000-12-21 2003-09-09 Scimed Life Systems, Inc. Infusion devices and method
GB0100247D0 (en) 2001-01-05 2001-02-14 Univ Dundee Improved hypodermic needle and fluid injection device
US7850663B2 (en) 2001-01-12 2010-12-14 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
WO2002056947A1 (en) 2001-01-18 2002-07-25 Medrad, Inc. Syringe interfaces and adapters for use with medical injectors
US7008421B2 (en) * 2002-08-21 2006-03-07 Resect Medical, Inc. Apparatus and method for tissue resection
EP1387671A1 (en) * 2001-05-03 2004-02-11 MASSACHUSETTS EYE & EAR INFIRMARY Implantable drug delivery device and use thereof
AU2002320147A1 (en) 2001-06-22 2003-01-08 University Of Florida Microdialysis probes and methods of use
EP1415156B1 (en) 2001-07-10 2009-09-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of multiple proteins in single cells
US6796957B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Sterile aspiration/reinjection systems
US20030060780A1 (en) 2001-09-24 2003-03-27 Shu Hang Chung Epidermic injection device
US20030134810A1 (en) 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6840921B1 (en) 2002-01-11 2005-01-11 Timothy D. Haider Apparatus and methods for simultaneously administering two or more medications to a patient
AU2003230601A1 (en) 2002-03-07 2003-09-22 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Clinical syringe with electrical stimulation aspects
US6942633B2 (en) * 2002-03-22 2005-09-13 Twin Star Medical, Inc. System for treating tissue swelling
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
JP4044779B2 (ja) 2002-04-02 2008-02-06 株式会社根本杏林堂 薬液注入システム
JP2005534430A (ja) 2002-08-06 2005-11-17 ジェンベック, インコーポレイテッド 改良された注射システム
US20050187303A1 (en) 2002-09-26 2005-08-25 Wu Men-Dar Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
US20060206950A1 (en) 2002-11-04 2006-09-14 Kaelin William G Jr In vivo imaging of e2f-fegulated bioluminescent proteins
US6896666B2 (en) 2002-11-08 2005-05-24 Kochamba Family Trust Cutaneous injection delivery under suction
KR20060038407A (ko) 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
JP2007130028A (ja) 2003-07-01 2007-05-31 Junko Asano 薬剤塗付医療用具
JP2007501608A (ja) 2003-08-08 2007-02-01 株式会社 キャンバス 抗癌治療の効力を推定するための感受性試験
IL157696A0 (en) 2003-09-01 2004-03-28 Hawk Medical Technologies Ltd Apparatus and method for removing a pigmented section of skin
BRPI0415629A (pt) 2003-10-31 2006-12-12 Alza Corp aplicador auto-atuador para conjunto de microprojeções
US20050126304A1 (en) 2003-11-24 2005-06-16 Integrated Sensing Systems, Inc. Fluid infusion method and system therefor
US7674579B2 (en) * 2003-11-26 2010-03-09 Yale University Apoptosis-based evaluation of chemosensitivity in cancer patients
US20060094046A1 (en) 2004-02-11 2006-05-04 Arie Abo Compositions and methods relating to angiogenesis and tumorigenesis
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20060058966A1 (en) 2004-09-15 2006-03-16 Bruckner Howard W Methods and systems for guiding selection of chemotherapeutic agents
US20060079846A1 (en) 2004-10-08 2006-04-13 Alton Williams Hypodermic syringes with multiple needles and methods of calming psychiatric patients using such
US7627938B2 (en) 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same
KR101224257B1 (ko) 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
WO2006078725A1 (en) 2005-01-20 2006-07-27 Massachusetts Institute Of Technology Soft polylactides
JP2006239260A (ja) 2005-03-07 2006-09-14 Hakko Co Ltd 薬液注入器具
US20060224118A1 (en) 2005-03-31 2006-10-05 Morris Mary M Medical fluid delivery system
US20080009802A1 (en) 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
EP2324880B1 (en) 2005-04-27 2014-12-24 C.R. Bard, Inc. Infusion apparatuses provided with septum
US7850656B2 (en) 2005-04-29 2010-12-14 Warsaw Orthopedic, Inc. Devices and methods for delivering medical agents
US20080269666A1 (en) * 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
US20070093748A1 (en) 2005-06-23 2007-04-26 Medtronic Vascular, Inc. Methods and systems for treating injured cardiac tissue
US7396524B2 (en) 2005-08-02 2008-07-08 Main Line Health Heart Center Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy
US20070038181A1 (en) * 2005-08-09 2007-02-15 Alexander Melamud Method, system and device for delivering a substance to tissue
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US7799035B2 (en) 2005-11-18 2010-09-21 Carefusion 2200, Inc. Device, system and method for delivering a curable material into bone
US8734823B2 (en) 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US20070162110A1 (en) 2006-01-06 2007-07-12 Vipul Bhupendra Dave Bioabsorbable drug delivery devices
EP1986656A4 (en) * 2006-02-02 2012-05-16 Univ South Florida WITHACNISTINE COMPOUNDS FOR THE TREATMENT OF CANCER
CA2642481C (en) 2006-02-16 2016-04-05 David W. Smith System utilizing radio frequency signals for tracking and improving navigation of slender instruments during insertion into the body
WO2007103070A2 (en) 2006-03-03 2007-09-13 Genetronics, Inc. Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
WO2007123274A1 (ja) 2006-04-20 2007-11-01 Eisai R & D Management Co., Ltd. スルホンアミド化合物の新規感受性マーカー
US20070287952A1 (en) * 2006-04-27 2007-12-13 Shah Jay P Microdialysis probe
US7771741B2 (en) 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US7621895B2 (en) 2006-05-17 2009-11-24 Abbott Cardiovascular Systems Inc. Needle array devices and methods
WO2007138098A2 (en) 2006-05-31 2007-12-06 Projech Science To Technology, S.L. Animal models of tumour metastasis and toxicity
US7922672B2 (en) 2006-06-08 2011-04-12 Lincoln Diagnostics, Inc. Skin testing-device system
BRPI0602640B8 (pt) 2006-07-06 2021-05-25 Anhanguera Educacional Ltda métodos de obtenção de penta-1,4-dien-3-onas e de cicloexanonas substituídas e derivados com propriedades antitumorais e antiparasitárias, processo para preparar 1,5-bis-(aril)-penta-1,4-dien-3-onas alquiladas e aciladas, processo para preparar 4-nitro-3,5-diaril-cicloexanonas substituídas, processo para preparar 2,6-dibenzilideno-4-nitro-3,5-diaril-cicloexanonas substituídas, processo para preparar uma mistura formada por quantidades determinadas dos compostos (1,5-bis(4-hidróxi-3-metóxi-fenil)penta-1,4-dien-3-ona) e (1,5-bis(3-metóxi-4-acetóxi-fenil)penta-1,4-dien-3-ona), compostos e seus usos, composição farmacêutica, método terapêutico para tratamento dos cânceres e composição sinérgica
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
US20090270834A1 (en) 2006-08-21 2009-10-29 Koninklijke Philips Electronics N.V. Drug delivery device
DE102006040642A1 (de) 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
US7711409B2 (en) 2006-10-04 2010-05-04 Hampton University Opposed view and dual head detector apparatus for diagnosis and biopsy with image processing methods
US20080140026A1 (en) 2006-12-11 2008-06-12 Sliwa John W Acoustically-Aided and/or gel-aided delivery of beneficial gaseous, ionic, unstable, metastable, short-lived or reactive species for medical purposes
WO2008072229A2 (en) * 2006-12-12 2008-06-19 Nanopass Technologies Ltd. Methods for dermal filling using microneedles
US7935086B2 (en) 2006-12-14 2011-05-03 L M M Global Innovations, Inc. Multiple drug injection apparatus
US20080214987A1 (en) 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US20100196439A1 (en) 2006-12-22 2010-08-05 Medtronic, Inc. Angiogenesis Mechanism and Method, and Implantable Device
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
JP2010532701A (ja) 2007-07-06 2010-10-14 ボストン サイエンティフィック サイムド,インコーポレイテッド 調整可能な細孔容積を有する埋め込み型医療装置および該装置を製造するための方法
SG183726A1 (en) 2007-08-14 2012-09-27 Hutchinson Fred Cancer Res Needle array assembly and method for delivering therapeutic agents
US20090093871A1 (en) 2007-10-08 2009-04-09 Medtronic Vascular, Inc. Medical Implant With Internal Drug Delivery System
US20090105562A1 (en) * 2007-10-19 2009-04-23 Taipei Veterans General Hospital System and methods for screening or analyzing targets
WO2009055542A1 (en) 2007-10-26 2009-04-30 University Of Utah Research Foundation Use of mri contrast agents for evaluating the treatment of tumors
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
FR2924715B1 (fr) 2007-12-06 2012-10-12 Arkema France Materiau forme de molecules arborescentes comportant des groupes associatifs
US20090234322A1 (en) 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
JP5798918B2 (ja) 2008-08-21 2015-10-21 ナインポイント メディカル, インコーポレイテッド 薬物評価および局所処置のためのデバイスおよび方法
EP2370115B1 (en) 2008-12-04 2016-08-03 Technion Research & Development Foundation Ltd. Hydrogel sponges, methods of producing them and uses thereof
SG173069A1 (en) 2009-01-23 2011-08-29 Quadra Logic Tech Inc Sustained released delivery of one or more agents
CN103492016A (zh) 2010-11-23 2014-01-01 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
WO2012071514A1 (en) 2010-11-23 2012-05-31 Fred Hutchinson Cancer Research Center Therapeutic methods for solid delivery
AU2012328457A1 (en) 2011-10-28 2014-04-24 Presage Biosciences, Inc. Methods for drug delivery
US20130184593A1 (en) 2011-12-30 2013-07-18 Kibur Medical, Inc. Implantable Devices And Methods For The Evaluation of Active Agents

Also Published As

Publication number Publication date
AU2012328457A1 (en) 2014-04-24
US20140323907A1 (en) 2014-10-30
WO2013063530A2 (en) 2013-05-02
JP2014534864A (ja) 2014-12-25
US10478157B2 (en) 2019-11-19
CN104023760A (zh) 2014-09-03
EP2771043A4 (en) 2015-04-29
WO2013063530A3 (en) 2013-06-20
SG11201401851UA (en) 2014-05-29
US20170296154A1 (en) 2017-10-19
SG10201508662SA (en) 2015-11-27
EP2771043A2 (en) 2014-09-03
US20140378944A1 (en) 2014-12-25

Similar Documents

Publication Publication Date Title
US10478157B2 (en) Methods for drug delivery
US20140155861A1 (en) Extrusion methods and devices for drug delivery
JP5588344B2 (ja) 治療薬をデリバリーするための針アレイアセンブリ及び方法
US20170184606A1 (en) Methods for multiplexed drug evaluation
KR20210042048A (ko) 로우 프로파일 다중-작용제 주입 시스템 및 방법
Barros et al. A human skin-on-a-chip platform for microneedling-driven skin cancer treatment
WO2015164541A1 (en) Methods and devices for evaluating drug candidates
Molnar et al. Regional thymidine transport and incorporation in experimental brain and subcutaneous tumors
Gatti Modification of pH and Pressure in a Microfluidic Cell Culture Device

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151026

FZDE Discontinued

Effective date: 20220518

FZDE Discontinued

Effective date: 20220518