CA2849968A1 - Compositions and methods for treatment of neuropsychological deficits - Google Patents
Compositions and methods for treatment of neuropsychological deficits Download PDFInfo
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- CA2849968A1 CA2849968A1 CA2849968A CA2849968A CA2849968A1 CA 2849968 A1 CA2849968 A1 CA 2849968A1 CA 2849968 A CA2849968 A CA 2849968A CA 2849968 A CA2849968 A CA 2849968A CA 2849968 A1 CA2849968 A1 CA 2849968A1
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Family Cites Families (68)
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| US6451341B1 (en) | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| US5096712A (en) * | 1990-03-06 | 1992-03-17 | Interneuron Pharmaceuticals, Inc. | Method for enhancing performance so as to improve vigor and decrease fatigue, confusion, tension, and anxiety |
| US5292538A (en) | 1992-07-22 | 1994-03-08 | Metagenics, Inc. | Improved sustained energy and anabolic composition and method of making |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5948443A (en) | 1996-02-23 | 1999-09-07 | Medical Doctor's Research Institute, Inc. | Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease |
| US5895652A (en) | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| JP2001511153A (ja) | 1997-02-04 | 2001-08-07 | ブイ． コスバブ，ジョン | 血管変性性疾患の予防および処置のための組成物および方法 |
| IT1291113B1 (it) | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US5916912A (en) | 1997-06-16 | 1999-06-29 | The Regents Of The University Of California | Dietary composition for enhancing metabolism and alleviating oxidative stress |
| US6048846A (en) | 1998-02-26 | 2000-04-11 | Cochran; Timothy M. | Compositions used in human treatment |
| US6191162B1 (en) | 1998-05-28 | 2001-02-20 | Medical Research Institute | Method of reducing serum glucose levels |
| IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US20030206895A1 (en) | 1998-11-13 | 2003-11-06 | Sigma-Tau Healthscience S.P.A. | Antioxidant composition comprising propionyl L-carnitine and a flavonoid against throm-bosis and atherosclerosis |
| EP1175158A1 (en) | 1999-05-07 | 2002-01-30 | Trustees Of Tufts College | Immune stimulating dietary supplement and methods of use thereof |
| CA2377414A1 (en) | 1999-06-15 | 2000-12-21 | John D. Potter | Nutrient formulations for disease reduction, and related treatment and component screening methods |
| US6103756A (en) | 1999-08-11 | 2000-08-15 | Vitacost Inc. | Ocular orally ingested composition for prevention and treatment of individuals |
| US6479069B1 (en) | 1999-09-23 | 2002-11-12 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| AU8003800A (en) * | 1999-10-08 | 2001-04-23 | Joyce Corinne Bechthold | Methods and compositions for treating neurobehavioral disorders |
| US20020155163A1 (en) | 1999-12-27 | 2002-10-24 | Samuel D. Benjamin | Integrated multi-vitamin and mineral combination |
| US6458384B2 (en) | 2000-02-23 | 2002-10-01 | Impetus Ag | Pharmaceutical with predetermined activity profile |
| US6579544B1 (en) | 2000-05-31 | 2003-06-17 | Nutriex, L.L.C. | Method for supplementing the diet |
| US6423349B1 (en) | 2000-08-24 | 2002-07-23 | Baxter International, Inc. | Therapeutic nutrient composition for pre and post elective surgery |
| US20070117869A1 (en) | 2000-11-01 | 2007-05-24 | Cognition Pharmaceuticals Llc | Methods for treating coginitive impairment and improving cognition |
| WO2005000203A2 (en) | 2001-10-31 | 2005-01-06 | Sention, Inc. | Methods for treating cognitive impairment and improving cognition |
| US6733797B1 (en) | 2000-11-15 | 2004-05-11 | William K. Summers | Neuroceutical for improving memory and cognitive abilities |
| US20020176900A1 (en) | 2000-11-22 | 2002-11-28 | Inna Yegorova | Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow |
| US6300377B1 (en) | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| WO2002087593A1 (en) | 2001-04-25 | 2002-11-07 | Cobalz Limited | A method for treating or preventing a functional vitamin b12 deficiency in an individual and to medical compositions for use in said method |
| US20020165281A1 (en) * | 2001-04-26 | 2002-11-07 | Assa Weinberg | Treatment of anoxic encephalophathy by administration of N-acetylcystein |
| DE60232522D1 (de) | 2001-07-11 | 2009-07-16 | Cns Response Inc | Verfahren zur vorhersage der behandlungsresultate |
| US6541043B2 (en) | 2001-08-28 | 2003-04-01 | Dexgen Pharmaceuticals, Inc. | Method and synergistic composition for treating attention deficit/hyperactivity disorder |
| US20030049272A1 (en) | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
| WO2003028747A1 (en) | 2001-10-04 | 2003-04-10 | Harris Dennis H | Ingestible nerve and circulatory nutritional formulation |
| EP1304048B1 (en) | 2001-10-22 | 2004-09-22 | Ivo Pera | Composition to reduce or quit smoking addiction |
| GB2381451A (en) | 2001-11-01 | 2003-05-07 | New Technology Res Ltd | Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect |
| US20040077556A1 (en) | 2002-04-22 | 2004-04-22 | Robert Chinery | Compositions and methods for promoting weight loss, thermogenesis, appetite suppression, lean muscle mass, increasing metabolism and boosting energy levels, and use as a dietary supplement in mammals |
| US7585523B2 (en) | 2002-08-27 | 2009-09-08 | Targeted Medical Pharma | Composition and method to augment and sustain neurotransmitter production |
| US7968125B2 (en) | 2003-04-08 | 2011-06-28 | Janeel Henderson | Energy generating composition |
| US20070237834A1 (en) | 2003-04-18 | 2007-10-11 | Bioderm Research | Zinc Zeolite for the Treatment for Diaper Rash (Diaper Dermatitis) |
| US20050058672A1 (en) | 2003-09-14 | 2005-03-17 | Bioderm Research | Baby Care Skin Protectant Compositions for Diaper Rash |
| CN1826105B (zh) * | 2003-05-23 | 2010-09-08 | 认知医药品有限责任公司 | 安非他明组合物在生产认知能力损伤的药剂中的应用 |
| US8211873B2 (en) | 2003-08-29 | 2012-07-03 | Island Kinetics, Inc. | Antiaging chirally-correct mitoprotectant amino acid and peptide complexes |
| CA2550625C (en) | 2003-12-31 | 2013-05-28 | Integrative Health Consulting, Inc. | Nutrient compositions and methods for enhanced effectiveness of the immune system |
| PL1797109T3 (pl) | 2004-09-09 | 2016-11-30 | Mieszaniny polipeptydów, kompozycje zawierające je i procesy ich wytwarzania oraz ich zastosowania | |
| MX2007006324A (es) | 2004-11-29 | 2007-10-17 | Aloecorp Inc | Deshidratacion de combinaciones de alimentos. |
| US7250181B2 (en) | 2005-01-19 | 2007-07-31 | Natreon, Inc. | Polyherbal compositions and methods for treating viral infections |
| US7776915B2 (en) | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| JPWO2006112283A1 (ja) * | 2005-04-13 | 2008-12-11 | 理研ビタミン株式会社 | 抗疲労剤 |
| US20060257502A1 (en) | 2005-05-11 | 2006-11-16 | Jiankang Liu | A combination of mitochondrial nutrients for relieving stress, preventing and improving stress-related disorders |
| US7645742B2 (en) | 2005-06-22 | 2010-01-12 | Advocare International, L.P. | Composition for enhancing cellular energy |
| US7893070B2 (en) | 2005-08-15 | 2011-02-22 | Provimi Holding B.V. | Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion |
| US7976879B2 (en) | 2005-11-04 | 2011-07-12 | Roizen Michael F | Nutritional supplement product to suppress age-related decline in cognitive capacity and other aging functions |
| JP4904795B2 (ja) * | 2005-12-06 | 2012-03-28 | 大正製薬株式会社 | 疲労改善剤組成物 |
| MX2008011639A (es) | 2006-03-13 | 2008-09-23 | Hershey Co | Composiciones de infusion de cacao y bebidas funcionales de cacao elaboradas a partir de las mismas. |
| US7972633B2 (en) | 2007-02-07 | 2011-07-05 | Applied Cognitive Sciences, LLC | Nutritional supplements for healthy memory and mental function |
| EP2433654A3 (en) | 2007-02-08 | 2013-05-15 | Kempharm, Inc. | Citrulline and homocitrulline prodrugs of amphetamines and processes for making and using the same |
| US8187647B2 (en) | 2008-06-13 | 2012-05-29 | BioClinical Development, Inc. | Edible energy composition |
| WO2009098697A1 (en) | 2008-02-08 | 2009-08-13 | Dexxon Ltd. | Modafinil and sildenafil dosage forms |
| EP2259782A4 (en) | 2008-03-03 | 2013-01-23 | Nad Life Pty Ltd | PHARMACEUTICAL FORMULATIONS OF RESVERATROL AND METHOD FOR THEIR USE IN THE TREATMENT OF CELL DISEASES |
| US20090325999A1 (en) | 2008-06-27 | 2009-12-31 | Jie Du | Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions |
| MX2011001384A (es) | 2008-08-06 | 2011-09-27 | Gosforth Ct Holdings Pty Ltd | Composiciones y metodos para tratar trastornos psiquiatricos. |
| US8642095B2 (en) | 2008-09-30 | 2014-02-04 | Visalus Holdings, Llc | Dietary composition and method of using the same |
| CA2785056A1 (en) | 2009-12-22 | 2011-07-21 | Pondera Biotechnologies, LLC | Methods and compositions for treating distress dysfunction and enhancing safety and efficacy of specific medications |
| JP5811545B2 (ja) * | 2010-06-24 | 2015-11-11 | 国立研究開発法人理化学研究所 | 疲労のバイオマーカーおよびその利用 |
| US9872850B2 (en) | 2010-12-23 | 2018-01-23 | Amazentis Sa | Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders |
| US9040082B2 (en) | 2011-06-24 | 2015-05-26 | K-Pax Pharmaceuticals, Inc. | Compositions and methods for treatment of chronic fatigue |
-
2012
- 2012-06-22 US US13/530,673 patent/US9040082B2/en active Active
- 2012-11-30 WO PCT/US2012/067347 patent/WO2013191724A1/en not_active Ceased
- 2012-11-30 EP EP12879324.7A patent/EP2879495A4/en not_active Withdrawn
- 2012-11-30 JP JP2015518386A patent/JP2015520229A/ja active Pending
- 2012-11-30 AU AU2012382949A patent/AU2012382949A1/en not_active Abandoned
- 2012-11-30 CA CA2849968A patent/CA2849968A1/en not_active Abandoned
-
2015
- 2015-05-06 US US14/705,573 patent/US20150250761A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120328695A1 (en) | 2012-12-27 |
| EP2879495A1 (en) | 2015-06-10 |
| WO2013191724A1 (en) | 2013-12-27 |
| US20150250761A1 (en) | 2015-09-10 |
| EP2879495A4 (en) | 2016-03-09 |
| AU2012382949A8 (en) | 2014-09-04 |
| AU2012382949A1 (en) | 2014-01-30 |
| US9040082B2 (en) | 2015-05-26 |
| JP2015520229A (ja) | 2015-07-16 |
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