CA2849920A1 - Methods and compositions for regulating hiv infection - Google Patents
Methods and compositions for regulating hiv infection Download PDFInfo
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- CA2849920A1 CA2849920A1 CA 2849920 CA2849920A CA2849920A1 CA 2849920 A1 CA2849920 A1 CA 2849920A1 CA 2849920 CA2849920 CA 2849920 CA 2849920 A CA2849920 A CA 2849920A CA 2849920 A1 CA2849920 A1 CA 2849920A1
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| RU2721275C2 (ru) | 2012-12-12 | 2020-05-18 | Те Брод Инститьют, Инк. | Доставка, конструирование и оптимизация систем, способов и композиций для манипуляции с последовательностями и применения в терапии |
| EP3434776A1 (en) | 2012-12-12 | 2019-01-30 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| CA2915837A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute, Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| EP3011029B1 (en) | 2013-06-17 | 2019-12-11 | The Broad Institute, Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| WO2014204729A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
| BR112015031608A2 (pt) | 2013-06-17 | 2017-08-22 | Massachusetts Inst Technology | Aplicação e uso dos sistemas crispr-cas, vetores e composições para direcionamento e terapia hepáticos |
| AU2014281030B2 (en) | 2013-06-17 | 2020-07-09 | Massachusetts Institute Of Technology | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| CA2930877A1 (en) * | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| MX374529B (es) | 2013-12-12 | 2025-03-06 | Broad Inst Inc | Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para edicion del genoma. |
| EP4219699A1 (en) | 2013-12-12 | 2023-08-02 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
| EP3080261B1 (en) | 2013-12-12 | 2019-05-22 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| EP3080257A1 (en) | 2013-12-12 | 2016-10-19 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
| CN106536729A (zh) | 2013-12-12 | 2017-03-22 | 布罗德研究所有限公司 | 使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用 |
| WO2016014837A1 (en) * | 2014-07-25 | 2016-01-28 | Sangamo Biosciences, Inc. | Gene editing for hiv gene therapy |
| EP3985115A1 (en) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| EP3702456A1 (en) | 2014-12-24 | 2020-09-02 | The Broad Institute, Inc. | Crispr having or associated with destabilization domains |
| US10059940B2 (en) * | 2015-01-27 | 2018-08-28 | Minghong Zhong | Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents |
| WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| WO2016205613A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzyme mutations reducing off-target effects |
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| EP1352960A1 (en) * | 2002-04-12 | 2003-10-15 | Viruvation B.V. | Antiviral therapy on the basis of RNA interference |
| US20100055793A1 (en) * | 2005-07-25 | 2010-03-04 | Johns Hopkins University | Site-specific modification of the human genome using custom-designed zinc finger nucleases |
| CN101273141B (zh) * | 2005-07-26 | 2013-03-27 | 桑格摩生物科学股份有限公司 | 外源核酸序列的靶向整合和表达 |
| US20080003681A1 (en) * | 2006-06-28 | 2008-01-03 | Mahalaxmi Gita Bangera | Methods for altering cellular susceptibility to infection |
| US8563314B2 (en) * | 2007-09-27 | 2013-10-22 | Sangamo Biosciences, Inc. | Methods and compositions for modulating PD1 |
| US8193161B2 (en) * | 2008-06-09 | 2012-06-05 | New York Medical College | Compositions comprising cardiac stem cells overexpressing specific micrornas and methods of their use in repairing damaged myocardium |
| CA2755192C (en) * | 2009-03-20 | 2018-09-11 | Sangamo Biosciences, Inc. | Modification of cxcr4 using engineered zinc finger proteins |
| DK2462230T3 (en) * | 2009-08-03 | 2015-10-19 | Recombinetics Inc | METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION |
| CN102071219B (zh) * | 2010-11-05 | 2014-03-12 | 冯小荣 | 改腺载体及其在艾滋病预防和治疗药物中的应用 |
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2012
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- 2012-10-04 US US13/645,175 patent/US20130171732A1/en not_active Abandoned
- 2012-10-04 HK HK15101108.0A patent/HK1200491A1/xx unknown
- 2012-10-04 JP JP2014534726A patent/JP2014530603A/ja active Pending
- 2012-10-04 EP EP12838704.0A patent/EP2764102A4/en not_active Withdrawn
- 2012-10-04 WO PCT/US2012/058775 patent/WO2013052681A1/en not_active Ceased
- 2012-10-04 CA CA 2849920 patent/CA2849920A1/en not_active Abandoned
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2015
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| WO2013052681A1 (en) | 2013-04-11 |
| EP2764102A4 (en) | 2015-06-10 |
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| JP2014530603A (ja) | 2014-11-20 |
| AU2012318562A1 (en) | 2014-04-10 |
| EP2764102A1 (en) | 2014-08-13 |
| US20150267223A1 (en) | 2015-09-24 |
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