CA2846454A1 - Synergistic combinations of pi3k- and mek-inhibitors - Google Patents
Synergistic combinations of pi3k- and mek-inhibitors Download PDFInfo
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- CA2846454A1 CA2846454A1 CA2846454A CA2846454A CA2846454A1 CA 2846454 A1 CA2846454 A1 CA 2846454A1 CA 2846454 A CA2846454 A CA 2846454A CA 2846454 A CA2846454 A CA 2846454A CA 2846454 A1 CA2846454 A1 CA 2846454A1
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- fluoro
- amide
- pharmaceutically acceptable
- compound
- cancer
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- 229960001860 salicylate Drugs 0.000 description 1
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- 238000009495 sugar coating Methods 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529380P | 2011-08-31 | 2011-08-31 | |
| US61/529,380 | 2011-08-31 | ||
| US201161542463P | 2011-10-03 | 2011-10-03 | |
| US61/542,463 | 2011-10-03 | ||
| PCT/US2012/052955 WO2013066483A1 (en) | 2011-08-31 | 2012-08-30 | Synergistic combinations of pi3k- and mek-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2846454A1 true CA2846454A1 (en) | 2013-05-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2846454A Abandoned CA2846454A1 (en) | 2011-08-31 | 2012-08-30 | Synergistic combinations of pi3k- and mek-inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9675595B2 (https=) |
| EP (1) | EP2750675A1 (https=) |
| JP (1) | JP6058009B2 (https=) |
| KR (1) | KR20140072028A (https=) |
| CN (1) | CN103764144B (https=) |
| AU (1) | AU2012333092B2 (https=) |
| BR (1) | BR112014004587A2 (https=) |
| CA (1) | CA2846454A1 (https=) |
| MX (1) | MX2014002471A (https=) |
| RU (1) | RU2607944C2 (https=) |
| WO (1) | WO2013066483A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3613743B1 (en) | 2008-01-04 | 2022-03-16 | Intellikine, LLC | Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| RU2015156221A (ru) * | 2013-06-11 | 2017-07-17 | Новартис Аг | Фармацевтические комбинация ингибитора pi3k и средства, дестабилизирующего микротрубочки |
| KR20160020502A (ko) * | 2013-06-18 | 2016-02-23 | 노파르티스 아게 | 제약 조합물 |
| BR112016012141A2 (pt) * | 2014-01-15 | 2017-08-08 | Novartis Ag | "combinações farmacêuticas, uso das mesmas, e embalagem comercial" |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US20150320754A1 (en) * | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| AU2016349279A1 (en) * | 2015-11-03 | 2018-05-10 | Board Of Regents, The University Of Texas System | Combination of Bcl-2 inhibitor and MEK inhibitor for the treatment of cancer |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| WO2020053125A1 (en) * | 2018-09-10 | 2020-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of neurofibromatosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3401A1 (fr) | 2000-07-19 | 2002-01-24 | Warner Lambert Co | Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques |
| RU2192861C1 (ru) | 2001-06-29 | 2002-11-20 | Новосибирский институт биоорганической химии СО РАН | Композиция для антибластической терапии |
| SG2013013339A (en) * | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| AU2005252110B2 (en) | 2004-06-11 | 2008-09-04 | Shionogi & Co., Ltd. | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer |
| RU2368602C2 (ru) * | 2005-01-26 | 2009-09-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназ |
| SG177981A1 (en) | 2005-05-18 | 2012-02-28 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| PE20070335A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| DK2074122T5 (da) | 2006-09-15 | 2014-03-17 | Pfizer Prod Inc | Pyrido (2, 3-d) pyrimidin0n-forbindelser og anvendelse deraf som pi3 inhibitorer |
| KR20110028651A (ko) * | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (ａ) 포스포이노시타이드 3-키나제 억제제 및 (ｂ) ｒａｓ/ｒａｆ/ｍｅｋ 경로의 조절제의 조합물 |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| KR101489045B1 (ko) * | 2009-10-12 | 2015-02-02 | 에프. 호프만-라 로슈 아게 | Ｐｉ3ｋ 억제자 및 ｍｅｋ 억제자의 조합 |
-
2012
- 2012-08-30 CN CN201280041783.7A patent/CN103764144B/zh not_active Expired - Fee Related
- 2012-08-30 US US14/240,499 patent/US9675595B2/en active Active
- 2012-08-30 KR KR1020147004859A patent/KR20140072028A/ko not_active Ceased
- 2012-08-30 RU RU2014112198A patent/RU2607944C2/ru not_active IP Right Cessation
- 2012-08-30 JP JP2014528568A patent/JP6058009B2/ja active Active
- 2012-08-30 CA CA2846454A patent/CA2846454A1/en not_active Abandoned
- 2012-08-30 BR BR112014004587A patent/BR112014004587A2/pt not_active IP Right Cessation
- 2012-08-30 MX MX2014002471A patent/MX2014002471A/es unknown
- 2012-08-30 EP EP12824789.7A patent/EP2750675A1/en not_active Withdrawn
- 2012-08-30 WO PCT/US2012/052955 patent/WO2013066483A1/en not_active Ceased
- 2012-08-30 AU AU2012333092A patent/AU2012333092B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2607944C2 (ru) | 2017-01-11 |
| US20140179744A1 (en) | 2014-06-26 |
| AU2012333092B2 (en) | 2016-04-21 |
| AU2012333092A1 (en) | 2014-03-06 |
| EP2750675A1 (en) | 2014-07-09 |
| MX2014002471A (es) | 2014-03-27 |
| US9675595B2 (en) | 2017-06-13 |
| CN103764144B (zh) | 2016-07-20 |
| WO2013066483A1 (en) | 2013-05-10 |
| CN103764144A (zh) | 2014-04-30 |
| JP2014525454A (ja) | 2014-09-29 |
| RU2014112198A (ru) | 2015-10-10 |
| BR112014004587A2 (pt) | 2017-03-14 |
| JP6058009B2 (ja) | 2017-01-11 |
| KR20140072028A (ko) | 2014-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170728 |
|
| FZDE | Discontinued |
Effective date: 20190830 |