CA2845851A1 - Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions - Google Patents

Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions Download PDF

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Publication number
CA2845851A1
CA2845851A1 CA2845851A CA2845851A CA2845851A1 CA 2845851 A1 CA2845851 A1 CA 2845851A1 CA 2845851 A CA2845851 A CA 2845851A CA 2845851 A CA2845851 A CA 2845851A CA 2845851 A1 CA2845851 A1 CA 2845851A1
Authority
CA
Canada
Prior art keywords
agent
compound
group
nanoparticle
attachment component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2845851A
Other languages
English (en)
French (fr)
Inventor
Thomas E. Rogers
Kah Tiong KUAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt LLC
Original Assignee
Mallinckrodt LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt LLC filed Critical Mallinckrodt LLC
Publication of CA2845851A1 publication Critical patent/CA2845851A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2845851A 2011-08-31 2012-08-30 Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions Abandoned CA2845851A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161529665P 2011-08-31 2011-08-31
US61/529,665 2011-08-31
PCT/US2012/053211 WO2013033450A2 (en) 2011-08-31 2012-08-30 Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions

Publications (1)

Publication Number Publication Date
CA2845851A1 true CA2845851A1 (en) 2013-03-07

Family

ID=46832627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2845851A Abandoned CA2845851A1 (en) 2011-08-31 2012-08-30 Remote assembly of targeted nanoparticles using h-phosphonate-ene/-yne hydrophosphonylation reactions

Country Status (9)

Country Link
US (2) US9216225B2 (enExample)
EP (1) EP2750711A2 (enExample)
JP (1) JP2014525459A (enExample)
KR (1) KR20140064917A (enExample)
CN (1) CN103945869A (enExample)
BR (1) BR112014004716A2 (enExample)
CA (1) CA2845851A1 (enExample)
IL (1) IL231216A0 (enExample)
WO (1) WO2013033450A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9918190B2 (en) * 2015-02-18 2018-03-13 Cisco Technology, Inc. Augmenting network device management
FR3046728B1 (fr) * 2016-01-19 2020-04-03 Centre National De La Recherche Scientifique Nouvelles nanoparticules d'organosilice mesoporeuses, leur methode de preparation et leurs utilisations.
JPWO2019009434A1 (ja) * 2017-07-06 2020-07-02 学校法人京都薬科大学 薬物送達用高分子ミセル

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940961A (en) * 1957-08-09 1960-06-14 Eastman Kodak Co Alkyl 1-acetoxyalkenylphosphonates and polymers thereof
US3006945A (en) * 1960-09-01 1961-10-31 Ethyl Corp Preparation of organic compounds
US3224973A (en) * 1960-09-01 1965-12-21 Ethyl Corp Dialkyl hydroxybenzyl phosphonates as antioxidants
US3367870A (en) * 1963-09-12 1968-02-06 Geigy Chem Corp Method of stabilization with carbonbonded phosphorus derivatives and compositions stabilized thereby
US3681481A (en) 1969-11-12 1972-08-01 Hooker Chemical Corp Catalytic addition of compounds having a p-h bond to acetylene
FR2460958A1 (fr) * 1979-07-09 1981-01-30 Elf Aquitaine Nouveaux composes diphosphoniques, utiles a l'extraction des metaux lourds
EP0023173B1 (fr) * 1979-07-09 1983-12-14 Societe Nationale Elf Aquitaine (Production) Nouveaux esters diphosphoniques et triphosphoniques, leurs préparation et applications
US4820698A (en) * 1985-11-04 1989-04-11 The Procter & Gamble Company Antimicrobial agents and process for their manufacture
US4798872A (en) * 1986-04-28 1989-01-17 Ashland Oil, Inc. Alkylene phosphonate acid ester polyols
DE3643684A1 (de) * 1986-12-20 1988-06-30 Hoechst Ag Verfahren zur herstellung von halogenierten phosphono-phosphorsaeureestern und ihre verwendung
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5321153A (en) * 1992-06-15 1994-06-14 Monsanto Company Process for making chiral alpha-amino phosphonates selected novel chiral alpha-amino phosphonates
JPH07140615A (ja) * 1993-11-12 1995-06-02 Fuji Photo Film Co Ltd ハロゲン化銀カラー感光材料
JPH07140606A (ja) * 1993-11-19 1995-06-02 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
DE4410601A1 (de) * 1994-03-26 1995-09-28 Boehringer Mannheim Gmbh Neue 2.4-Diphosphonoglutarsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1996024599A1 (en) * 1995-02-10 1996-08-15 Akzo Nobel N.V. Synthesis of a hydrocarbylvinyl phosphonic acid hydrocarbyl ester
JP2775426B2 (ja) * 1995-09-14 1998-07-16 工業技術院長 不飽和ホスホン酸エステルの製造方法
GB9613722D0 (en) * 1996-06-28 1996-08-28 Univ Liverpool Chemical compounds
JP3007984B1 (ja) * 1999-03-08 2000-02-14 工業技術院長 不飽和ホスホン酸エステルの製造方法
MXPA02005490A (es) * 1999-12-03 2004-09-10 Univ California San Diego Compuestos de fosfonato.
JP3610371B2 (ja) * 2000-03-13 2005-01-12 独立行政法人産業技術総合研究所 （α−及び／又はβ−ホルミルエチル）ホスフィンオキシド化合物、（α−及び／又はβ−ホルミルエチル）ホスホン酸エステル化合物とその製造方法
DE10049074A1 (de) 2000-10-02 2002-04-18 Andreas Kage Verfahren zur Selektion hochaffin an ein Target bindender Nukleinsäuren
GB0025849D0 (en) * 2000-10-23 2000-12-06 Smithkline Beecham Plc Novel compounds
DE10054218A1 (de) 2000-11-02 2002-05-08 Basf Ag Verfahren zur Herstellung von Alkenylphosphonsäure-Derivaten
WO2003094851A2 (en) * 2002-05-11 2003-11-20 Ilex Products, Inc. 1,1- and 1,2-bisphosphonates as apoliprotein e modulators
JP3836395B2 (ja) * 2002-05-17 2006-10-25 独立行政法人科学技術振興機構 アルケニルリン化合物の製造方法
DE102004032781A1 (de) * 2004-01-23 2005-08-11 Mcs Micro Carrier Systems Gmbh Bisphosphonsäurederivate
JP4314366B2 (ja) * 2004-02-18 2009-08-12 独立行政法人産業技術総合研究所 含リンブタジエン化合物の製造方法
WO2006078646A2 (en) 2005-01-18 2006-07-27 Caltagirone Gaetano T A class of supramolecular drug molecules and methods of identification and use thereof
US20100021519A1 (en) * 2006-04-27 2010-01-28 Narmada Shenoy Compositions and Methods for Treating or Preventing Diseases of Body Passageways
CN1887890A (zh) * 2006-07-17 2007-01-03 华中师范大学 具有除草活性的α－酰氧基烯基膦酸酯及制备
CN1903862B (zh) * 2006-07-20 2012-10-10 华中师范大学 具有除草活性的取代甲酰氧基烃基膦酸酯类光学活性异构体及制备
FR2921838A1 (fr) * 2007-10-05 2009-04-10 Guerbet Sa Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile
CN103288696B (zh) * 2008-05-30 2015-08-19 住友化学株式会社 磷酸奥司他韦的中间体化合物
EP2533764A4 (en) * 2010-02-08 2016-08-31 Univ Nebraska BIOMINERAL AND METAL BINDING LIPOSOME, THEIR SYNTHESIS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
CN103945869A (zh) 2014-07-23
EP2750711A2 (en) 2014-07-09
IL231216A0 (en) 2014-04-30
WO2013033450A2 (en) 2013-03-07
KR20140064917A (ko) 2014-05-28
US20130066098A1 (en) 2013-03-14
WO2013033450A3 (en) 2013-09-06
JP2014525459A (ja) 2014-09-29
US9216225B2 (en) 2015-12-22
BR112014004716A2 (pt) 2017-03-28
US20160060280A1 (en) 2016-03-03

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170830

FZDE Discontinued

Effective date: 20170830