CA2841954C - 5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia - Google Patents
5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia Download PDFInfo
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- CA2841954C CA2841954C CA2841954A CA2841954A CA2841954C CA 2841954 C CA2841954 C CA 2841954C CA 2841954 A CA2841954 A CA 2841954A CA 2841954 A CA2841954 A CA 2841954A CA 2841954 C CA2841954 C CA 2841954C
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
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- 238000011221 initial treatment Methods 0.000 description 1
- 229960002198 irbesartan Drugs 0.000 description 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229960002394 lisinopril Drugs 0.000 description 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 1
- 229960004773 losartan Drugs 0.000 description 1
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 1
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- 230000001404 mediated effect Effects 0.000 description 1
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- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- YZMHQCWXYHARLS-UHFFFAOYSA-N naphthalene-1,2-disulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(S(=O)(=O)O)=CC=C21 YZMHQCWXYHARLS-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
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- 229960005117 olmesartan Drugs 0.000 description 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 description 1
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- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
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- 230000020874 response to hypoxia Effects 0.000 description 1
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- 239000000523 sample Substances 0.000 description 1
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- 229960005187 telmisartan Drugs 0.000 description 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 description 1
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- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508260P | 2011-07-15 | 2011-07-15 | |
| US61/508,260 | 2011-07-15 | ||
| PCT/US2012/046427 WO2013012670A1 (en) | 2011-07-15 | 2012-07-12 | Treatment for hypoxia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2841954A1 CA2841954A1 (en) | 2013-01-24 |
| CA2841954C true CA2841954C (en) | 2020-05-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2841954A Expired - Fee Related CA2841954C (en) | 2011-07-15 | 2012-07-12 | 5-hydroxymethyl-2furfural (5-hmf) as treatment for hypoxia |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9918958B2 (enExample) |
| EP (1) | EP2731602A1 (enExample) |
| JP (1) | JP2014520854A (enExample) |
| AU (1) | AU2012284361B2 (enExample) |
| BR (1) | BR112014000889A2 (enExample) |
| CA (1) | CA2841954C (enExample) |
| WO (1) | WO2013012670A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016043849A2 (en) | 2014-07-24 | 2016-03-24 | Global Blood Therapeutics, Inc. | Compounds for treating acute respiratory distress syndrome or a negative effect thereof |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| JP7265237B2 (ja) * | 2017-07-27 | 2023-04-26 | 共栄化学工業株式会社 | 毛髪用組成物及び皮膚外用組成物 |
| US20240423948A1 (en) * | 2021-10-11 | 2024-12-26 | D-Cap Llc | 5-hydroxymethylfurfural for the treatment of mitochondrial dysfunction |
| US11458144B1 (en) | 2021-12-23 | 2022-10-04 | King Abdulaziz University | Methods for using 5-HMF analogs with increased solubility to inhibit or reverse RBC sickling |
| CN117085005A (zh) * | 2023-10-08 | 2023-11-21 | 山东省科学院生物研究所 | 5-羟甲基-2-呋喃甲酸在制备促血管生成相关产品中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1567490B1 (en) * | 2002-12-04 | 2011-10-05 | Virginia Commonwealth University | Anti-sickling agents |
| EP2255623A1 (en) * | 2009-05-26 | 2010-12-01 | Volker Wagner-Solbach | Plant nutriments |
| JP5916717B2 (ja) | 2010-05-18 | 2016-05-11 | アスレックス エルエルシーＡｅｓｒｘ Ｌｌｃ | 高地低酸素症の処置 |
-
2012
- 2012-07-12 BR BR112014000889A patent/BR112014000889A2/pt not_active Application Discontinuation
- 2012-07-12 US US13/547,462 patent/US9918958B2/en not_active Expired - Fee Related
- 2012-07-12 EP EP12738335.4A patent/EP2731602A1/en not_active Withdrawn
- 2012-07-12 JP JP2014520312A patent/JP2014520854A/ja active Pending
- 2012-07-12 AU AU2012284361A patent/AU2012284361B2/en not_active Ceased
- 2012-07-12 CA CA2841954A patent/CA2841954C/en not_active Expired - Fee Related
- 2012-07-12 WO PCT/US2012/046427 patent/WO2013012670A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013012670A1 (en) | 2013-01-24 |
| EP2731602A1 (en) | 2014-05-21 |
| CA2841954A1 (en) | 2013-01-24 |
| AU2012284361A1 (en) | 2014-01-30 |
| BR112014000889A2 (pt) | 2017-10-31 |
| AU2012284361A2 (en) | 2014-02-13 |
| AU2012284361B2 (en) | 2016-11-17 |
| US9918958B2 (en) | 2018-03-20 |
| JP2014520854A (ja) | 2014-08-25 |
| US20130018092A1 (en) | 2013-01-17 |
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| Trialist | CMEddddddddddddddddddddddd |
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