CA2839435C - Systemes, procedes et dispositifs concernant une unite nephronique cellularisee biomimetique - Google Patents

Systemes, procedes et dispositifs concernant une unite nephronique cellularisee biomimetique Download PDF

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Publication number
CA2839435C
CA2839435C CA2839435A CA2839435A CA2839435C CA 2839435 C CA2839435 C CA 2839435C CA 2839435 A CA2839435 A CA 2839435A CA 2839435 A CA2839435 A CA 2839435A CA 2839435 C CA2839435 C CA 2839435C
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Prior art keywords
cells
flow channel
flow
kidney
bioartificial kidney
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CA2839435A
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CA2839435A1 (fr
Inventor
Joseph L. Charest
Else FROHLICH
Jeffrey T. Borenstein
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Charles Stark Draper Laboratory Inc
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Charles Stark Draper Laboratory Inc
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Publication of CA2839435A1 publication Critical patent/CA2839435A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention a pour objet des systèmes et des dispositifs permettant de cultiver des cellules dans un environnement biomimétique d'une unité néphronique cellularisée, ainsi que des procédés de fabrication et d'utilisation de ladite unité néphronique cellularisée.
CA2839435A 2011-06-15 2012-06-15 Systemes, procedes et dispositifs concernant une unite nephronique cellularisee biomimetique Active CA2839435C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161497376P 2011-06-15 2011-06-15
US61/497,376 2011-06-15
US201161497854P 2011-06-16 2011-06-16
US61/497,854 2011-06-16
PCT/US2012/042791 WO2012174460A1 (fr) 2011-06-15 2012-06-15 Systèmes, procédés et dispositifs concernant une unité néphronique cellularisée biomimétique

Publications (2)

Publication Number Publication Date
CA2839435A1 CA2839435A1 (fr) 2012-12-20
CA2839435C true CA2839435C (fr) 2021-05-11

Family

ID=46545449

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2839435A Active CA2839435C (fr) 2011-06-15 2012-06-15 Systemes, procedes et dispositifs concernant une unite nephronique cellularisee biomimetique

Country Status (7)

Country Link
US (1) US9657261B2 (fr)
EP (1) EP2720731B1 (fr)
JP (1) JP6041872B2 (fr)
CN (1) CN103764190B (fr)
AU (1) AU2012271341B2 (fr)
CA (1) CA2839435C (fr)
WO (1) WO2012174460A1 (fr)

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US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
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WO2015013332A1 (fr) 2013-07-22 2015-01-29 President And Fellows Of Harvard College Ensemble cartouche microfluidique
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USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
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Also Published As

Publication number Publication date
CN103764190A (zh) 2014-04-30
CN103764190B (zh) 2019-03-08
AU2012271341B2 (en) 2017-07-13
EP2720731B1 (fr) 2020-11-18
JP6041872B2 (ja) 2016-12-14
US9657261B2 (en) 2017-05-23
EP2720731A1 (fr) 2014-04-23
JP2014518105A (ja) 2014-07-28
CA2839435A1 (fr) 2012-12-20
WO2012174460A1 (fr) 2012-12-20
AU2012271341A1 (en) 2014-01-09
US20120318726A1 (en) 2012-12-20

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