CA2838973A1 - Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies - Google Patents
Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies Download PDFInfo
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- CA2838973A1 CA2838973A1 CA2838973A CA2838973A CA2838973A1 CA 2838973 A1 CA2838973 A1 CA 2838973A1 CA 2838973 A CA2838973 A CA 2838973A CA 2838973 A CA2838973 A CA 2838973A CA 2838973 A1 CA2838973 A1 CA 2838973A1
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- dll4
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- 238000002628 unsealed source radiotherapy Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- DNYWZCXLKNTFFI-UHFFFAOYSA-N uranium Chemical compound [U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U] DNYWZCXLKNTFFI-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 230000006496 vascular abnormality Effects 0.000 description 1
- 230000006459 vascular development Effects 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 239000004066 vascular targeting agent Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000012447 xenograft mouse model Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498200P | 2011-06-17 | 2011-06-17 | |
| US61/498,200 | 2011-06-17 | ||
| PCT/US2012/042695 WO2012174394A1 (en) | 2011-06-17 | 2012-06-15 | Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2838973A1 true CA2838973A1 (en) | 2012-12-20 |
Family
ID=46397640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2838973A Abandoned CA2838973A1 (en) | 2011-06-17 | 2012-06-15 | Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8685401B2 (enExample) |
| EP (1) | EP2721070A1 (enExample) |
| JP (1) | JP2014523421A (enExample) |
| AU (1) | AU2012271450A1 (enExample) |
| CA (1) | CA2838973A1 (enExample) |
| WO (1) | WO2012174394A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2895226T3 (es) | 2009-10-16 | 2022-02-18 | Mereo Biopharma 5 Inc | Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos |
| PT2758073T (pt) | 2011-09-23 | 2019-02-01 | Oncomed Pharm Inc | Agentes de ligação a vegf/dll4 e utilizações dos mesmos |
| AU2015338974B2 (en) | 2014-10-31 | 2021-08-26 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| EP3638245A1 (en) * | 2017-06-12 | 2020-04-22 | Agios Pharmaceuticals, Inc. | Methods of treating brain tumors using combination therapy |
| CA3067035A1 (en) | 2017-06-12 | 2018-12-20 | Agios Pharmaceuticals, Inc. | Methods of treating brain tumors using combination therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| HUE028379T2 (en) | 2006-09-29 | 2016-12-28 | Oncomed Pharm Inc | Preparations and procedures for the diagnosis and treatment of cancer |
| EP2344536A1 (en) * | 2008-09-19 | 2011-07-20 | MedImmune, LLC | Antibodies directed to dll4 and uses thereof |
| US20110059114A1 (en) * | 2009-08-05 | 2011-03-10 | Duke University | Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2012
- 2012-06-15 WO PCT/US2012/042695 patent/WO2012174394A1/en not_active Ceased
- 2012-06-15 AU AU2012271450A patent/AU2012271450A1/en not_active Abandoned
- 2012-06-15 EP EP12730733.8A patent/EP2721070A1/en not_active Withdrawn
- 2012-06-15 JP JP2014516039A patent/JP2014523421A/ja not_active Ceased
- 2012-06-15 US US13/524,396 patent/US8685401B2/en not_active Expired - Fee Related
- 2012-06-15 CA CA2838973A patent/CA2838973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012174394A1 (en) | 2012-12-20 |
| JP2014523421A (ja) | 2014-09-11 |
| US20130006034A1 (en) | 2013-01-03 |
| AU2012271450A1 (en) | 2014-01-16 |
| EP2721070A1 (en) | 2014-04-23 |
| US8685401B2 (en) | 2014-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170615 |