CA2834584C - Fgfr-fc fusion protein and use thereof - Google Patents
Fgfr-fc fusion protein and use thereof Download PDFInfo
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- CA2834584C CA2834584C CA2834584A CA2834584A CA2834584C CA 2834584 C CA2834584 C CA 2834584C CA 2834584 A CA2834584 A CA 2834584A CA 2834584 A CA2834584 A CA 2834584A CA 2834584 C CA2834584 C CA 2834584C
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
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| CN201110132218.9 | 2011-05-20 | ||
| CN201110132218A CN102219860B (zh) | 2011-05-20 | 2011-05-20 | FGFR-Fc融合蛋白及其用途 |
| PCT/CN2012/075706 WO2012159550A1 (zh) | 2011-05-20 | 2012-05-18 | FGFR-Fc融合蛋白及其用途 |
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| CA2834584A1 CA2834584A1 (en) | 2012-11-29 |
| CA2834584C true CA2834584C (en) | 2019-05-14 |
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| EP (2) | EP3173102B1 (enExample) |
| JP (1) | JP2014513941A (enExample) |
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| CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
| AU2013295805B2 (en) * | 2012-07-24 | 2019-05-02 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
| EA201591324A1 (ru) | 2013-01-16 | 2016-01-29 | Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) | Полипептид растворимого рецептора 3 фактора роста фибробластов (fgr3) для применения с целью предотвращения или лечения нарушений, связанных с замедлением роста скелета |
| US9957313B2 (en) | 2013-03-15 | 2018-05-01 | Remegen, Ltd. | FGFR-FC fusion proteins and the use thereof |
| CN105307669A (zh) * | 2013-05-23 | 2016-02-03 | 戊瑞治疗有限公司 | 治疗癌症的方法 |
| KR102046448B1 (ko) * | 2014-02-07 | 2019-11-19 | 프린시피아 바이오파마, 인코퍼레이티드 | 섬유모세포 성장 인자 수용체 저해제로서 퀴놀론 유도체들 |
| CN105983093A (zh) * | 2015-02-11 | 2016-10-05 | 烟台荣昌生物工程有限公司 | 血管新生因子融合蛋白在制备用于治疗与血管新生相关的眼部疾病药物中的应用 |
| WO2018007597A1 (en) | 2016-07-07 | 2018-01-11 | Therachon | Soluble fibroblast growth factor receptor 3 (sfgfr3) polypeptides and uses thereof |
| US11357842B2 (en) * | 2017-03-17 | 2022-06-14 | Vaximm Ag | PD-L1 targeting DNA vaccine for cancer immunotherapy |
| RU2760738C1 (ru) | 2018-12-07 | 2021-11-30 | Ремеджен Ко., Лтд. | Бифункциональный ингибитор ангиогенеза и его применение |
| CN116143941B (zh) * | 2022-09-08 | 2024-06-04 | 浙江省血液中心 | 一种KIR3DL1-IgG-Fc融合重组蛋白、应用及试剂盒 |
| CN116199744B (zh) * | 2023-03-23 | 2024-06-25 | 湖南中晟全肽生物科技股份有限公司 | 一种结合fgfr2受体的多肽及其用途 |
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| WO2000046380A2 (en) * | 1999-02-08 | 2000-08-10 | Chiron Corporation | Fibroblast growth factor receptor-immunoglobulin fusion |
| DE102005007665A1 (de) | 2005-02-19 | 2006-08-31 | Degussa Ag | Folie auf Basis eines Polyamidblends |
| EP1910542B1 (en) * | 2005-07-22 | 2009-12-02 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| KR20090031897A (ko) | 2006-06-12 | 2009-03-30 | 리셉터 바이오로직스 인크 | 전-세포 표면 수용체-특이적 치료제 |
| RU2341198C2 (ru) * | 2006-11-27 | 2008-12-20 | ФГУ Ростовский научно-исследовательский онкологический институт Росздрава | Способ оценки ангиогенных факторов при химиотерапии рака молочной железы |
| CL2007003411A1 (es) * | 2006-11-28 | 2008-07-04 | Centelion | Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu |
| ZA200903134B (en) * | 2006-11-28 | 2010-08-25 | Centelion | Modified soluble FGF receptor FC fusions with improved biological activity |
| WO2008133873A2 (en) * | 2007-04-25 | 2008-11-06 | Aveo Pharmaceuticals, Inc. | Fgf-binding fusion proteins |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| CA2732449A1 (en) * | 2008-08-04 | 2010-02-11 | Five Prime Therapeutics, Inc. | Fgfr extracellular domain acidic region muteins |
| ES2600631T3 (es) * | 2009-11-13 | 2017-02-10 | Five Prime Therapeutics, Inc. | Uso de proteínas del dominio extracelular de FGFR1 para tratar cánceres caracterizados por mutaciones activadoras dependientes de ligando en FGFR2 |
| CN102219859B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
| CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
-
2011
- 2011-05-20 CN CN201110132218A patent/CN102219860B/zh active Active
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2012
- 2012-05-18 BR BR112013022285-9A patent/BR112013022285B1/pt active IP Right Grant
- 2012-05-18 DK DK16205128.8T patent/DK3173102T3/da active
- 2012-05-18 JP JP2014505502A patent/JP2014513941A/ja active Pending
- 2012-05-18 KR KR1020167001261A patent/KR101660336B1/ko active Active
- 2012-05-18 EP EP16205128.8A patent/EP3173102B1/en active Active
- 2012-05-18 CA CA2834584A patent/CA2834584C/en active Active
- 2012-05-18 RU RU2013140184/10A patent/RU2560573C2/ru active
- 2012-05-18 AU AU2012261412A patent/AU2012261412B2/en active Active
- 2012-05-18 KR KR1020137023245A patent/KR20130119978A/ko not_active Ceased
- 2012-05-18 EP EP12788998.8A patent/EP2711376B1/en active Active
- 2012-05-18 WO PCT/CN2012/075706 patent/WO2012159550A1/zh not_active Ceased
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- 2013-03-15 US US13/842,345 patent/US9273137B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2560573C2 (ru) | 2015-08-20 |
| AU2012261412B2 (en) | 2016-02-25 |
| JP2014513941A (ja) | 2014-06-19 |
| EP2711376B1 (en) | 2018-07-25 |
| EP2711376A1 (en) | 2014-03-26 |
| BR112013022285B1 (pt) | 2020-05-12 |
| US20160176945A1 (en) | 2016-06-23 |
| US20130195864A1 (en) | 2013-08-01 |
| KR20130119978A (ko) | 2013-11-01 |
| US9273137B2 (en) | 2016-03-01 |
| EP2711376A4 (en) | 2015-06-03 |
| EP3173102A1 (en) | 2017-05-31 |
| DK3173102T3 (da) | 2020-02-24 |
| BR112013022285A2 (pt) | 2016-12-06 |
| KR101660336B1 (ko) | 2016-09-27 |
| AU2012261412A1 (en) | 2013-08-29 |
| KR20160011241A (ko) | 2016-01-29 |
| WO2012159550A1 (zh) | 2012-11-29 |
| CN102219860A (zh) | 2011-10-19 |
| CA2834584A1 (en) | 2012-11-29 |
| CN102219860B (zh) | 2012-09-12 |
| EP3173102B1 (en) | 2019-11-20 |
| RU2013140184A (ru) | 2015-07-10 |
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