CA2832611C - Methods for inhibiting allograft rejection - Google Patents
Methods for inhibiting allograft rejection Download PDFInfo
- Publication number
- CA2832611C CA2832611C CA2832611A CA2832611A CA2832611C CA 2832611 C CA2832611 C CA 2832611C CA 2832611 A CA2832611 A CA 2832611A CA 2832611 A CA2832611 A CA 2832611A CA 2832611 C CA2832611 C CA 2832611C
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- inhibitor
- jak1
- compound
- combination
- immunosuppressant
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
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| Application Number | Priority Date | Filing Date | Title |
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| US201161474606P | 2011-04-12 | 2011-04-12 | |
| US61/474,606 | 2011-04-12 | ||
| PCT/US2012/033123 WO2012142160A1 (en) | 2011-04-12 | 2012-04-11 | Methods for inhibiting allograft rejection |
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| CA2832611A1 CA2832611A1 (en) | 2012-10-18 |
| CA2832611C true CA2832611C (en) | 2019-05-14 |
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| EP (1) | EP2696869B1 (enExample) |
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| WO2012015972A1 (en) * | 2010-07-28 | 2012-02-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US8637038B2 (en) * | 2011-04-12 | 2014-01-28 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
| US20160022648A1 (en) * | 2013-03-13 | 2016-01-28 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for meibomian gland dysfunction |
| KR102014349B1 (ko) * | 2016-08-17 | 2019-08-26 | 서울대학교 산학협력단 | Jak 억제제를 포함하는 면역반응 억제용 조성물 |
| US20190247511A1 (en) * | 2016-10-17 | 2019-08-15 | Medical University Of South Carolina | Compositions and methods for treating and preventing transplant-associated injury |
| US11819520B2 (en) | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| AU2019225151A1 (en) * | 2018-02-23 | 2020-08-20 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| US12364715B2 (en) | 2018-02-23 | 2025-07-22 | Enzyvant Therapeutics Gmbh | Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use |
| KR102147802B1 (ko) * | 2018-11-07 | 2020-08-25 | 가톨릭대학교 산학협력단 | 신규 화합물 및 칼시뉴린 억제제를 포함하는 이식 거부 반응 또는 이식 거부 질환의 예방 및 치료용 조성물 |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| US7081489B2 (en) | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US6780324B2 (en) | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
| CA2516116A1 (en) | 2003-01-16 | 2004-08-05 | St. John's University | Nanoparticle based stabilization of ir fluorescent dyes |
| WO2006052285A2 (en) | 2004-05-13 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Polymeric nanoparticles and nanogels for extraction and release of compounds |
| DE602006000381T2 (de) | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| CA2605551A1 (en) | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| GB0613925D0 (en) | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
| WO2008118822A1 (en) | 2007-03-23 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US7834024B2 (en) * | 2007-03-26 | 2010-11-16 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| PT2384326E (pt) * | 2008-08-20 | 2014-06-09 | Zoetis Llc | Compostos de pirrolo[2,3-d]pirimidina |
| HRP20151325T1 (hr) * | 2009-01-23 | 2016-01-01 | Rigel Pharmaceuticals, Inc. | Pripravci i postupci za inhibiciju jak puta |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| US8637038B2 (en) * | 2011-04-12 | 2014-01-28 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
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| US20120263737A1 (en) | 2012-10-18 |
| US8637038B2 (en) | 2014-01-28 |
| EP2696869B1 (en) | 2017-08-23 |
| JP2014510789A (ja) | 2014-05-01 |
| CA2832611A1 (en) | 2012-10-18 |
| WO2012142160A1 (en) | 2012-10-18 |
| JP2018127487A (ja) | 2018-08-16 |
| JP2017075174A (ja) | 2017-04-20 |
| JP6129155B2 (ja) | 2017-05-17 |
| EP2696869A1 (en) | 2014-02-19 |
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