CA2830654A1 - Compositions comprising a filler product and at least one bioresorbable and biodegradable silica-based material - Google Patents
Compositions comprising a filler product and at least one bioresorbable and biodegradable silica-based material Download PDFInfo
- Publication number
- CA2830654A1 CA2830654A1 CA2830654A CA2830654A CA2830654A1 CA 2830654 A1 CA2830654 A1 CA 2830654A1 CA 2830654 A CA2830654 A CA 2830654A CA 2830654 A CA2830654 A CA 2830654A CA 2830654 A1 CA2830654 A1 CA 2830654A1
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- combination product
- composition
- hyaluronic acid
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 91
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 82
- 239000000463 material Substances 0.000 title claims abstract description 38
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 32
- 239000000945 filler Substances 0.000 title claims abstract description 29
- 239000000047 product Substances 0.000 claims abstract description 41
- 230000032683 aging Effects 0.000 claims abstract description 29
- 239000013066 combination product Substances 0.000 claims abstract description 26
- 229940127555 combination product Drugs 0.000 claims abstract description 26
- 231100000241 scar Toxicity 0.000 claims abstract description 17
- 208000032544 Cicatrix Diseases 0.000 claims abstract description 16
- 230000037387 scars Effects 0.000 claims abstract description 16
- 206010021639 Incontinence Diseases 0.000 claims abstract description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 62
- 229920002674 hyaluronan Polymers 0.000 claims description 62
- 229960003160 hyaluronic acid Drugs 0.000 claims description 60
- 239000000499 gel Substances 0.000 claims description 45
- 206010040954 Skin wrinkling Diseases 0.000 claims description 23
- 102000008186 Collagen Human genes 0.000 claims description 20
- 108010035532 Collagen Proteins 0.000 claims description 20
- 229920001436 collagen Polymers 0.000 claims description 20
- 229920000642 polymer Polymers 0.000 claims description 18
- 230000037303 wrinkles Effects 0.000 claims description 18
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 16
- 229960004194 lidocaine Drugs 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 12
- 230000003416 augmentation Effects 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
- 208000034347 Faecal incontinence Diseases 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 210000002950 fibroblast Anatomy 0.000 claims description 7
- 206010046543 Urinary incontinence Diseases 0.000 claims description 6
- 235000010443 alginic acid Nutrition 0.000 claims description 6
- 229920000615 alginic acid Polymers 0.000 claims description 6
- 239000004005 microsphere Substances 0.000 claims description 6
- 229920001059 synthetic polymer Polymers 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 5
- 229920002307 Dextran Polymers 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 5
- 238000006297 dehydration reaction Methods 0.000 claims description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 5
- 229920002439 Polyalkylimide Polymers 0.000 claims description 4
- 230000003444 anaesthetic effect Effects 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 229920002401 polyacrylamide Polymers 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 230000002550 fecal effect Effects 0.000 claims description 3
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 3
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- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000016942 Elastin Human genes 0.000 claims description 2
- 108010014258 Elastin Proteins 0.000 claims description 2
- 229920002549 elastin Polymers 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 42
- 210000001519 tissue Anatomy 0.000 description 22
- 238000002347 injection Methods 0.000 description 19
- 239000007924 injection Substances 0.000 description 19
- 239000003589 local anesthetic agent Substances 0.000 description 16
- 239000003431 cross linking reagent Substances 0.000 description 11
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 10
- 230000004048 modification Effects 0.000 description 10
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- 239000007863 gel particle Substances 0.000 description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920001605 Dextranomer Polymers 0.000 description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- 206010047370 Vesicoureteric reflux Diseases 0.000 description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229960004716 idoxuridine Drugs 0.000 description 4
- 239000007943 implant Substances 0.000 description 4
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- 230000001225 therapeutic effect Effects 0.000 description 4
- 201000008618 vesicoureteral reflux Diseases 0.000 description 4
- 208000031355 vesicoureteral reflux 1 Diseases 0.000 description 4
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- 239000011521 glass Substances 0.000 description 3
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- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000002485 urinary effect Effects 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 2
- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108030001720 Bontoxilysin Proteins 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 229960003831 articaine Drugs 0.000 description 2
- 229960005274 benzocaine Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000004067 bulking agent Substances 0.000 description 2
- 229960003150 bupivacaine Drugs 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
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- 229960002864 dextranomer Drugs 0.000 description 2
- OWQIUQKMMPDHQQ-UHFFFAOYSA-N dimethocaine Chemical compound CCN(CC)CC(C)(C)COC(=O)C1=CC=C(N)C=C1 OWQIUQKMMPDHQQ-UHFFFAOYSA-N 0.000 description 2
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- 238000009826 distribution Methods 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
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- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000007972 injectable composition Substances 0.000 description 2
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- 229920002521 macromolecule Polymers 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 2
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
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- HEGWNIMGIDYRAU-UHFFFAOYSA-N 3-hexyl-2,4-dioxabicyclo[1.1.0]butane Chemical compound O1C2OC21CCCCCC HEGWNIMGIDYRAU-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
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| US201161470211P | 2011-03-31 | 2011-03-31 | |
| US61/470,211 | 2011-03-31 | ||
| PCT/EP2012/055979 WO2012131095A1 (en) | 2011-03-31 | 2012-04-02 | Compositions comprising a filler product and at least one bioresorbable and biodegradable silica-based material |
Publications (1)
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|---|---|
| CA2830654A1 true CA2830654A1 (en) | 2012-10-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2830654A Abandoned CA2830654A1 (en) | 2011-03-31 | 2012-04-02 | Compositions comprising a filler product and at least one bioresorbable and biodegradable silica-based material |
Country Status (6)
| Country | Link |
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| US (1) | US20140065221A1 (enExample) |
| EP (1) | EP2691115A1 (enExample) |
| JP (1) | JP2014510590A (enExample) |
| BR (1) | BR112013025157A2 (enExample) |
| CA (1) | CA2830654A1 (enExample) |
| WO (1) | WO2012131095A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2427179A4 (en) | 2009-05-04 | 2013-09-11 | Psivida Inc | POROUS PARTICLES FOR THE RELEASE OF SILICIUM MEDICINES |
| RU2640918C2 (ru) | 2010-11-01 | 2018-01-12 | Псивида Юэс, Инк. | Биоразлагаемые устройства на основе кремния для доставки терапевтических агентов |
| CN105025928A (zh) | 2013-03-15 | 2015-11-04 | 普西维达公司 | 用于递送治疗剂的可生物蚀解的硅基组合物 |
| KR101647182B1 (ko) * | 2014-02-10 | 2016-08-23 | 박용호 | 피부조직 복원용 필러엑스(Filler X) 조성물 |
| US11389563B2 (en) | 2017-06-12 | 2022-07-19 | Advanced Aesthetic Technologies, Inc. | Dermal filler |
| EP3790602A1 (en) | 2018-05-09 | 2021-03-17 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
| ES3060255T3 (en) | 2018-05-09 | 2026-03-25 | Univ Johns Hopkins | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
| US11896715B2 (en) * | 2019-06-21 | 2024-02-13 | Korea University Research And Business Foundation | In vivo bulking agent, injection comprising same, and preparation method therefor |
| KR102264957B1 (ko) * | 2019-06-21 | 2021-06-17 | 고려대학교 산학협력단 | 체내 부피 유지 제제 및 이의 제조방법 |
| JP2025041170A (ja) * | 2023-09-13 | 2025-03-26 | 昌毅 本田 | 肛門狭窄化治療法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777041A (en) * | 1986-08-07 | 1988-10-11 | Charles Of The Ritz Group Ltd. | Wrinkle treatment formulation |
| US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
| JP2588109B2 (ja) * | 1993-03-19 | 1997-03-05 | 日本臓器製薬株式会社 | 鎮痛剤 |
| US5599852A (en) * | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| DE19609551C1 (de) | 1996-03-12 | 1997-07-17 | Fraunhofer Ges Forschung | Biologisch degradierbare und/oder biologisch resorbierbare (Endlos)Fasern, Verfahren zu deren Herstellung und deren Verwendung als Verstärkungsfasern |
| US6726932B2 (en) * | 2000-02-18 | 2004-04-27 | Nippon Zoki Pharmaceutical Co., Ltd. | Fatty acid-containing composition |
| US20040047892A1 (en) * | 2000-11-15 | 2004-03-11 | Desrosiers Eric Andre | Filler composition for soft tissue augmentation and reconstructive surgery |
| DE102007061873B4 (de) | 2007-01-15 | 2025-06-26 | Bayer Intellectual Property Gmbh | Kieselsol-Material zur Herstellung von biologisch degradierbaren und/oder resorbierbaren Kieselgel-Materialien, dessen Herstellung und Verwendung |
| ES2652114T3 (es) * | 2007-10-15 | 2018-01-31 | 7 Oaks Pharmaceutical Corporation | Una disolución que contiene silicato para uso en el tratamiento de melanoma |
| DE102008033327A1 (de) * | 2008-07-16 | 2010-01-21 | Bayer Innovation Gmbh | Kieselsol-Material mit mindestens einem therapeutisch aktiven Wirkstoff zur Herstellung von biologisch degradierbaren und/oder resorbierbaren Kieselgel-Materialien für die Humanmedizin und/oder Medizintechnik |
| DE102010008981A1 (de) * | 2010-02-24 | 2011-08-25 | Bayer Innovation GmbH, 40225 | Siliciumhaltiges, biologisch degradierbares Material zur pro-angiogenetischen Therapie |
-
2012
- 2012-04-02 US US14/006,745 patent/US20140065221A1/en not_active Abandoned
- 2012-04-02 WO PCT/EP2012/055979 patent/WO2012131095A1/en not_active Ceased
- 2012-04-02 BR BR112013025157A patent/BR112013025157A2/pt not_active IP Right Cessation
- 2012-04-02 JP JP2014501668A patent/JP2014510590A/ja active Pending
- 2012-04-02 EP EP12713943.4A patent/EP2691115A1/en not_active Withdrawn
- 2012-04-02 CA CA2830654A patent/CA2830654A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014510590A (ja) | 2014-05-01 |
| EP2691115A1 (en) | 2014-02-05 |
| US20140065221A1 (en) | 2014-03-06 |
| BR112013025157A2 (pt) | 2019-09-24 |
| WO2012131095A1 (en) | 2012-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20180403 |