CA2809716A1 - N-phenethyl-triazolonacetamidessubstitues et leur utilisation - Google Patents

N-phenethyl-triazolonacetamidessubstitues et leur utilisation Download PDF

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Publication number
CA2809716A1
CA2809716A1 CA2809716A CA2809716A CA2809716A1 CA 2809716 A1 CA2809716 A1 CA 2809716A1 CA 2809716 A CA2809716 A CA 2809716A CA 2809716 A CA2809716 A CA 2809716A CA 2809716 A1 CA2809716 A1 CA 2809716A1
Authority
CA
Canada
Prior art keywords
compound
mmol
formula
trifluoromethyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2809716A
Other languages
English (en)
Inventor
Chantal Fuerstner
Joerg Keldenich
Martina Delbeck
Peter Kolkhof
Axel Kretschmer
Elisabeth Pook
Carsten Schmeck
Hubert Truebel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Bayer Intellectual Property GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Intellectual Property GmbH filed Critical Bayer Intellectual Property GmbH
Publication of CA2809716A1 publication Critical patent/CA2809716A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2809716A 2010-09-02 2011-08-31 N-phenethyl-triazolonacetamidessubstitues et leur utilisation Abandoned CA2809716A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010040187A DE102010040187A1 (de) 2010-09-02 2010-09-02 Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung
DE102010040187.0 2010-09-02
PCT/EP2011/065000 WO2012028644A1 (fr) 2010-09-02 2011-08-31 N-phénéthyl-triazolonacétamidessubstitués et leur utilisation

Publications (1)

Publication Number Publication Date
CA2809716A1 true CA2809716A1 (fr) 2012-03-08

Family

ID=44653279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2809716A Abandoned CA2809716A1 (fr) 2010-09-02 2011-08-31 N-phenethyl-triazolonacetamidessubstitues et leur utilisation

Country Status (14)

Country Link
US (1) US9180120B2 (fr)
EP (1) EP2619188B1 (fr)
JP (1) JP5816284B2 (fr)
KR (1) KR20130138216A (fr)
CN (1) CN103370309A (fr)
AU (1) AU2011298391A1 (fr)
BR (1) BR112013005226A2 (fr)
CA (1) CA2809716A1 (fr)
DE (1) DE102010040187A1 (fr)
ES (1) ES2543750T3 (fr)
MX (1) MX2013002261A (fr)
RU (1) RU2013114413A (fr)
WO (1) WO2012028644A1 (fr)
ZA (1) ZA201302335B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010040924A1 (de) 2010-09-16 2012-03-22 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung
SG11201703199UA (en) 2014-11-03 2017-05-30 Bayer Pharma AG Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2017191117A1 (fr) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Antagonistes du récepteur v1a destinés à une utilisation dans le traitement de maladies rénales
KR102390194B1 (ko) 2020-08-03 2022-04-25 셀라이온바이오메드 주식회사 페닐알킬 카바메이트 화합물을 포함하는 Kca3.1채널 매개질환 치료용 조성물

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EP0412594B1 (fr) 1989-07-28 1996-01-03 Merck & Co. Inc. Triazolinones, triazolinethiones et triazolinimines substituées comme antagonistes d'angiotensine II
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US5326776A (en) 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
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EP0713848B1 (fr) 1994-10-28 1999-09-08 SUMIKA FINE CHEMICALS Company, Limited Procédé de production des carbinols optiquement actifs
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Also Published As

Publication number Publication date
ZA201302335B (en) 2015-11-25
EP2619188A1 (fr) 2013-07-31
CN103370309A (zh) 2013-10-23
MX2013002261A (es) 2013-05-22
JP2013538806A (ja) 2013-10-17
AU2011298391A1 (en) 2013-03-14
BR112013005226A2 (pt) 2016-05-03
EP2619188B1 (fr) 2015-05-06
US20130225646A1 (en) 2013-08-29
US9180120B2 (en) 2015-11-10
ES2543750T3 (es) 2015-08-21
AU2011298391A8 (en) 2013-06-13
DE102010040187A1 (de) 2012-03-08
RU2013114413A (ru) 2014-10-10
JP5816284B2 (ja) 2015-11-18
WO2012028644A1 (fr) 2012-03-08
KR20130138216A (ko) 2013-12-18

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160824

FZDE Discontinued

Effective date: 20190717