CA2798873C - Method of preparing liquid mixtures - Google Patents
Method of preparing liquid mixtures Download PDFInfo
- Publication number
- CA2798873C CA2798873C CA2798873A CA2798873A CA2798873C CA 2798873 C CA2798873 C CA 2798873C CA 2798873 A CA2798873 A CA 2798873A CA 2798873 A CA2798873 A CA 2798873A CA 2798873 C CA2798873 C CA 2798873C
- Authority
- CA
- Canada
- Prior art keywords
- liquid
- property
- conduit
- buffer
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 258
- 238000000034 method Methods 0.000 title claims abstract description 101
- 239000000203 mixture Substances 0.000 title description 33
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 239000000872 buffer Substances 0.000 claims description 142
- 230000008569 process Effects 0.000 claims description 47
- 238000002156 mixing Methods 0.000 claims description 35
- 238000002835 absorbance Methods 0.000 claims description 14
- 239000000654 additive Substances 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 9
- 238000004611 spectroscopical analysis Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 235000019846 buffering salt Nutrition 0.000 claims description 5
- 238000004497 NIR spectroscopy Methods 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 description 36
- 239000002253 acid Substances 0.000 description 31
- 239000011550 stock solution Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
- 230000002378 acidificating effect Effects 0.000 description 7
- 238000013459 approach Methods 0.000 description 7
- 230000007423 decrease Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 239000008215 water for injection Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000001276 controlling effect Effects 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 239000006172 buffering agent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000005588 protonation Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000012266 salt solution Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000006173 Good's buffer Substances 0.000 description 2
- 238000013494 PH determination Methods 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- -1 hydrogen ions Chemical class 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000010979 pH adjustment Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000004280 Sodium formate Substances 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
- 238000011095 buffer preparation Methods 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007785 strong electrolyte Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D21/00—Control of chemical or physico-chemical variables, e.g. pH value
- G05D21/02—Control of chemical or physico-chemical variables, e.g. pH value characterised by the use of electric means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0324—With control of flow by a condition or characteristic of a fluid
- Y10T137/0329—Mixing of plural fluids of diverse characteristics or conditions
Landscapes
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Automation & Control Theory (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Accessories For Mixers (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1050668 | 2010-06-23 | ||
| SE1050668-1 | 2010-06-23 | ||
| PCT/SE2011/050563 WO2011162666A1 (en) | 2010-06-23 | 2011-05-05 | Method of preparing liquid mixtures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2798873A1 CA2798873A1 (en) | 2011-12-29 |
| CA2798873C true CA2798873C (en) | 2019-04-16 |
Family
ID=45371782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2798873A Active CA2798873C (en) | 2010-06-23 | 2011-05-05 | Method of preparing liquid mixtures |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10955092B2 (enExample) |
| EP (1) | EP2585887B1 (enExample) |
| JP (1) | JP6014588B2 (enExample) |
| CN (1) | CN102947768B (enExample) |
| CA (1) | CA2798873C (enExample) |
| WO (1) | WO2011162666A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102947768B (zh) | 2010-06-23 | 2016-05-18 | 通用电气健康护理生物科学股份公司 | 制备液体混合物的方法 |
| GB201101075D0 (en) | 2011-01-21 | 2011-03-09 | Labminds Ltd | Automated solution dispenser |
| WO2013159057A1 (en) * | 2012-04-19 | 2013-10-24 | C. R. Bard, Inc. | Infusates with enhanced ph stability under ethylene oxide sterilization |
| DK2874736T3 (da) * | 2012-07-18 | 2023-05-22 | Accroma Labtec Ltd | Automatiseret opløsningsdispenser |
| US10076735B2 (en) | 2013-04-25 | 2018-09-18 | Gambro Lundia Ab | System and method for preparation of a medical fluid |
| WO2015047173A1 (en) | 2013-09-30 | 2015-04-02 | Ge Healthcare Bio-Sciences Ab | Method for preparation of liquid mixtures |
| WO2016042933A1 (ja) * | 2014-09-16 | 2016-03-24 | オルガノ株式会社 | 希釈液製造方法および希釈液製造装置 |
| EP3230729B1 (en) | 2014-12-12 | 2024-03-06 | Cytiva Sweden AB | System for preparing solutions for chromatography |
| WO2016097131A1 (en) | 2014-12-17 | 2016-06-23 | Ge Healthcare Bio-Sciences Ab | System for blending solutions |
| CN107835712B (zh) | 2015-02-06 | 2021-09-10 | 莱伯曼兹有限公司 | 自动化溶液分配器 |
| EP3259649A4 (en) | 2015-02-19 | 2018-09-19 | Asahi Kasei Bioprocess, Inc. | System and method for compensating binary inlet buffers during inline buffer diluation |
| CN104950932B (zh) * | 2015-06-10 | 2017-07-28 | 广东顺德中山大学卡内基梅隆大学国际联合研究院 | 基于张动力学的搅拌罐排空及浆液输出浓度保持的方法 |
| CN106249773A (zh) * | 2016-08-31 | 2016-12-21 | 张源兴 | 混合酸中单项酸检测控制装置 |
| CN110325852B (zh) * | 2016-08-31 | 2021-10-26 | 株式会社岛津制作所 | 液相色谱分析装置的控制装置和方法及液相色谱分析系统 |
| EP3625638B1 (de) | 2017-05-19 | 2021-05-19 | BASF Coatings GmbH | Produktionssystem zur herstellung von formulierungen |
| BR112019023666A2 (pt) * | 2017-05-19 | 2020-06-02 | Basf Coatings Gmbh | Sistema de produção para fabricação de formulações, e, processo para fabricar formulações |
| CN107413214A (zh) * | 2017-06-08 | 2017-12-01 | 利穗科技(苏州)有限公司 | 基于四元泵系统的缓冲液配置系统 |
| GB201709531D0 (en) * | 2017-06-15 | 2017-08-02 | Ge Healthcare Bio Sciences Ab | Method and apparatus for determining one or more buffer composition recipes |
| EP3699697A1 (en) | 2019-02-25 | 2020-08-26 | Bayer Aktiengesellschaft | Automated simultaneous process control |
| CN120294234A (zh) | 2019-02-28 | 2025-07-11 | 思拓凡瑞典有限公司 | 缓冲剂制备过程的控制 |
| EP4081795B1 (en) | 2019-12-23 | 2025-02-12 | Waters Technologies Corporation | Sample metering and injection for liquid chromatography |
| JP7388206B2 (ja) * | 2020-01-22 | 2023-11-29 | 株式会社島津製作所 | 液体クロマトグラフおよび分析方法 |
| NL2026599B1 (nl) * | 2020-10-01 | 2022-06-01 | Lely Patent Nv | Luchtwasser en werkwijze voor het wassen van ammoniakhoudende lucht, alsmede stalsysteem |
| CN114402968B (zh) * | 2022-01-21 | 2023-01-10 | 中国农业科学院农业环境与可持续发展研究所 | 一种沼液灌溉施肥系统及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3712513A (en) * | 1970-05-12 | 1973-01-23 | Du Pont | Apparatus and method for gradient elution |
| US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| US5264500A (en) * | 1991-07-30 | 1993-11-23 | Allied-Signal Inc. | APT resins |
| JP2971213B2 (ja) * | 1991-10-09 | 1999-11-02 | 日機装株式会社 | ｐＨ計の異常検出装置 |
| SE9600796D0 (sv) * | 1996-02-29 | 1996-02-29 | Pharmacia Biotech Ab | A method of preparing a liquid mixture |
| US5738772A (en) * | 1996-10-25 | 1998-04-14 | Fbc Industries, Inc. | In-line/on demand reaction delivery system and method |
| US6224778B1 (en) * | 1998-03-18 | 2001-05-01 | Charles T. Peltzer | Method for manufacturing a system for mixing fluids |
| US7344297B2 (en) | 1998-04-16 | 2008-03-18 | Air Liquide Electronics U.S. Lp | Method and apparatus for asynchronous blending and supply of chemical solutions |
| US20020189947A1 (en) * | 2001-06-13 | 2002-12-19 | Eksigent Technologies Llp | Electroosmotic flow controller |
| US7465382B2 (en) * | 2001-06-13 | 2008-12-16 | Eksigent Technologies Llc | Precision flow control system |
| JP3655569B2 (ja) * | 2001-09-06 | 2005-06-02 | 大陽日酸株式会社 | ガス成分濃度測定方法及び装置 |
| CA2506317A1 (en) * | 2002-11-18 | 2004-06-03 | Taurus Hsa Llc | Method for continuous, automated blending of solutions from acids and bases |
| WO2004103519A2 (en) * | 2003-05-16 | 2004-12-02 | Cryobiophysica, Inc. | External gradient chromatofocusing |
| WO2005025726A2 (en) | 2003-09-12 | 2005-03-24 | Gambro Lundia Ab | Preparation of liquids for a medical procedure |
| US8271139B2 (en) * | 2003-10-17 | 2012-09-18 | Asahi Kasei Bioprocess, Inc. | Multi-stage accurate blending system and method |
| US7515994B2 (en) | 2003-10-17 | 2009-04-07 | Technikrom, Inc. | Accurate blending module and method |
| WO2005082483A1 (en) * | 2004-02-27 | 2005-09-09 | Ge Healthcare Bio-Sciences Ab | A process for the purification of antibodies |
| WO2005083104A1 (ja) * | 2004-03-02 | 2005-09-09 | Zoegene Corporation | 無細胞タンパク質合成用細胞抽出液の製造法 |
| JP2006119945A (ja) * | 2004-10-22 | 2006-05-11 | Iwai Kikai Kogyo Co Ltd | 液体製品製造システム |
| DE602005025974D1 (de) * | 2005-03-31 | 2011-03-03 | Agilent Technologies Inc | Vorrichtung und Verfahren zur Bereitstellung von Lösungsmitteln mit Korrektur der Kolbenbewegung |
| DE602006006631D1 (de) * | 2006-07-21 | 2009-06-18 | Agilent Technologies Inc | Durchflussmesser mit einer Messvorrichtung und einer Steuereinheit |
| WO2009131524A1 (en) * | 2008-04-21 | 2009-10-29 | Ge Healthcare Bio-Sciences Ab | Preparation of liquid mixtures |
| CN102947768B (zh) | 2010-06-23 | 2016-05-18 | 通用电气健康护理生物科学股份公司 | 制备液体混合物的方法 |
| US8540120B2 (en) * | 2011-09-01 | 2013-09-24 | Global Agricultural Technology And Engineering, Llc | Fluid mixing and delivery system |
-
2011
- 2011-05-05 CN CN201180030718.XA patent/CN102947768B/zh active Active
- 2011-05-05 JP JP2013516523A patent/JP6014588B2/ja active Active
- 2011-05-05 EP EP11798441.9A patent/EP2585887B1/en active Active
- 2011-05-05 US US13/704,270 patent/US10955092B2/en active Active
- 2011-05-05 CA CA2798873A patent/CA2798873C/en active Active
- 2011-05-05 WO PCT/SE2011/050563 patent/WO2011162666A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2585887A1 (en) | 2013-05-01 |
| CA2798873A1 (en) | 2011-12-29 |
| JP6014588B2 (ja) | 2016-10-25 |
| CN102947768A (zh) | 2013-02-27 |
| EP2585887B1 (en) | 2019-01-09 |
| EP2585887A4 (en) | 2017-05-10 |
| JP2013529781A (ja) | 2013-07-22 |
| WO2011162666A1 (en) | 2011-12-29 |
| US20130081703A1 (en) | 2013-04-04 |
| US10955092B2 (en) | 2021-03-23 |
| CN102947768B (zh) | 2016-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160405 |