CA2798182A1 - Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry - Google Patents

Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry Download PDF

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Publication number
CA2798182A1
CA2798182A1 CA2798182A CA2798182A CA2798182A1 CA 2798182 A1 CA2798182 A1 CA 2798182A1 CA 2798182 A CA2798182 A CA 2798182A CA 2798182 A CA2798182 A CA 2798182A CA 2798182 A1 CA2798182 A1 CA 2798182A1
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CA
Canada
Prior art keywords
indicator
sample
intensity
belonging
standard
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2798182A
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English (en)
French (fr)
Inventor
Akos Vertes
Fatah Kashanchi
Prabhakar Sripadi
Kylene Kehnhall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
George Washington University
Original Assignee
George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George Washington University filed Critical George Washington University
Publication of CA2798182A1 publication Critical patent/CA2798182A1/en
Abandoned legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2798182A 2010-05-05 2010-05-05 Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry Abandoned CA2798182A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/033757 WO2011139274A1 (en) 2010-05-05 2010-05-05 Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry

Publications (1)

Publication Number Publication Date
CA2798182A1 true CA2798182A1 (en) 2011-11-10

Family

ID=44903919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2798182A Abandoned CA2798182A1 (en) 2010-05-05 2010-05-05 Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry

Country Status (4)

Country Link
EP (1) EP2567396A1 (ja)
JP (1) JP2013525810A (ja)
CA (1) CA2798182A1 (ja)
WO (1) WO2011139274A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11094517B2 (en) 2019-03-20 2021-08-17 Ricoh Company, Ltd. Method and device for preparing measurement sample for MALDI mass spectrometry, measurement sample for MALDI mass spectrometry, MALDI mass spectrometry method, and non-transitory recording medium for preparing measurement sample for MALDI mass spectrometry
WO2020225863A1 (ja) * 2019-05-08 2020-11-12 株式会社島津製作所 質量分析装置及び質量分析方法
WO2021173934A1 (en) * 2020-02-27 2021-09-02 Exum Instruments Mass spectrometry of samples including coaxial desorption/ablation and image capture
CN114361007B (zh) * 2020-10-13 2024-07-26 中国科学院大连化学物理研究所 一种用于单细胞高效离子化的多维调节装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3129250B2 (ja) * 1997-09-10 2001-01-29 株式会社ミルス生命科学研究所 尿の化学分析方法
JP2001330599A (ja) * 2000-05-24 2001-11-30 Shimazu S D Kk Ｇｃ／ｍｓによる代謝異常スクリーニング診断装置
CA2618123C (en) * 2005-08-08 2013-04-02 Metabolon Inc. A system, method, and computer program product using a database in a computing system to compile and compare metabolomic data obtained from a plurality of samples
US7714276B2 (en) * 2005-09-30 2010-05-11 New York University Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
US8067730B2 (en) * 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry

Also Published As

Publication number Publication date
JP2013525810A (ja) 2013-06-20
WO2011139274A1 (en) 2011-11-10
EP2567396A1 (en) 2013-03-13

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Effective date: 20160505