CA2797122C - Optical combiner for combining multiple laser beams in a flow cytometer - Google Patents

Optical combiner for combining multiple laser beams in a flow cytometer Download PDF

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Publication number
CA2797122C
CA2797122C CA2797122A CA2797122A CA2797122C CA 2797122 C CA2797122 C CA 2797122C CA 2797122 A CA2797122 A CA 2797122A CA 2797122 A CA2797122 A CA 2797122A CA 2797122 C CA2797122 C CA 2797122C
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CA
Canada
Prior art keywords
laser
laser beam
lens
adjuster
size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2797122A
Other languages
English (en)
French (fr)
Other versions
CA2797122A1 (en
Inventor
Susan Hunter
Daniel N. Fox
Tidhar Sadeh
Matthias J. G. Ottenberg
Kevin P. Raley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of CA2797122A1 publication Critical patent/CA2797122A1/en
Application granted granted Critical
Publication of CA2797122C publication Critical patent/CA2797122C/en
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/141—Beam splitting or combining systems operating by reflection only using dichroic mirrors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Laser Beam Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2797122A 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer Active CA2797122C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33084910P 2010-05-03 2010-05-03
US61/330,849 2010-05-03
PCT/US2011/035075 WO2011140153A1 (en) 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer

Publications (2)

Publication Number Publication Date
CA2797122A1 CA2797122A1 (en) 2011-11-10
CA2797122C true CA2797122C (en) 2019-02-26

Family

ID=44904046

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2797122A Active CA2797122C (en) 2010-05-03 2011-05-03 Optical combiner for combining multiple laser beams in a flow cytometer

Country Status (5)

Country Link
US (1) US8619370B2 (https=)
EP (1) EP2567204B1 (https=)
JP (1) JP5571845B2 (https=)
CA (1) CA2797122C (https=)
WO (1) WO2011140153A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2769203B1 (en) 2011-10-21 2019-01-16 Acea Biosciences, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
EP3071951B1 (en) * 2013-11-19 2019-10-30 ACEA Biosciences, Inc. Optical engine for flow cytometer, flow cytometer system and methods of use
US10261080B2 (en) 2013-11-19 2019-04-16 Acea Biosciences, Inc. Optical detection system for flow cytometer, flow cytometer system and methods of use
US9869628B2 (en) 2014-06-25 2018-01-16 Acea Biosciences, Inc. Methods of collecting cells from multi-well plates for use in flow cytometry
JP5719473B1 (ja) * 2014-09-25 2015-05-20 リオン株式会社 薬液用パーティクルカウンタ
WO2017060105A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Particle sensor for particle detection
KR20170079355A (ko) * 2015-12-30 2017-07-10 엘지이노텍 주식회사 발광 장치, 이 장치를 포함하는 광학 모듈, 및 이 모듈을 포함하는 차량
US10914913B2 (en) * 2018-03-30 2021-02-09 Idexx Laboratories, Inc. Flow cytometer, laser optics assembly thereof, and methods of assembling the same
CA3182847A1 (en) 2020-06-17 2021-12-23 Garland Christian Misener Flow cytometer and laser optics assembly thereof
US20220120658A1 (en) * 2020-10-20 2022-04-21 Becton, Dickinson And Company Flow cytometers including tilted beam shaping optical components, and methods of using the same
JP7312793B2 (ja) 2021-08-18 2023-07-21 京セラＳｏｃ株式会社 光源装置およびフローサイトメータ用レーザ光源装置

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Publication number Priority date Publication date Assignee Title
DE2408646A1 (de) 1974-02-22 1975-08-28 Max Planck Gesellschaft Reaktionskinetisches messgeraet
US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
JPH0665979B2 (ja) * 1985-07-26 1994-08-24 東亜医用電子株式会社 光による粒子検出装置
JPH01196536A (ja) * 1988-02-01 1989-08-08 Canon Inc 粒子解析装置
JPH0296638A (ja) * 1988-10-03 1990-04-09 Canon Inc 光学装置及び該光学装置を用いた粒子測定装置
JPH0213830A (ja) * 1988-06-30 1990-01-18 Canon Inc 粒子測定装置
JPH03154850A (ja) * 1989-11-13 1991-07-02 Canon Inc 検体検査装置
AU2001290568A1 (en) * 2000-08-25 2002-03-04 Amnis Corporation Measuring the velocity of small moving objects such as cells
US20070096039A1 (en) * 2002-05-03 2007-05-03 Rakesh Kapoor Evaluation Of Multicomponent Mixtures Using Modulated Light Beams
US7900836B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7468789B2 (en) 2004-02-05 2008-12-23 Advanced Analytical Technologies, Inc. Flow cytometer for rapid bacteria detection
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
WO2005107592A1 (ja) * 2004-05-06 2005-11-17 Nippon Telegraph And Telephone Corporation 成分濃度測定装置及び成分濃度測定装置制御方法
US7623435B2 (en) * 2004-08-20 2009-11-24 Pioneer Corporation Optical pickup device, and information recording and reproduction device
JP4357399B2 (ja) * 2004-10-08 2009-11-04 株式会社日立ハイテクノロジーズ 電気泳動装置
JP4762593B2 (ja) 2005-04-05 2011-08-31 オリンパス株式会社 外部レーザ導入装置
JP4756948B2 (ja) * 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
US20090010589A1 (en) 2005-08-30 2009-01-08 Robertson William M Optical sensor based on surface electromagnetic wave resonance in photonic band gap materials
JP2008254035A (ja) * 2007-04-05 2008-10-23 Disco Abrasive Syst Ltd レーザー加工装置
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Also Published As

Publication number Publication date
JP2013527929A (ja) 2013-07-04
WO2011140153A1 (en) 2011-11-10
US8619370B2 (en) 2013-12-31
CA2797122A1 (en) 2011-11-10
EP2567204B1 (en) 2021-12-29
EP2567204A4 (en) 2018-01-17
JP5571845B2 (ja) 2014-08-13
US20120105967A1 (en) 2012-05-03
EP2567204A1 (en) 2013-03-13

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Effective date: 20160503