CA2795438A1 - Method of detecting and profiling progression of the risk of neurodegenerative diseases - Google Patents

Method of detecting and profiling progression of the risk of neurodegenerative diseases Download PDF

Info

Publication number
CA2795438A1
CA2795438A1 CA2795438A CA2795438A CA2795438A1 CA 2795438 A1 CA2795438 A1 CA 2795438A1 CA 2795438 A CA2795438 A CA 2795438A CA 2795438 A CA2795438 A CA 2795438A CA 2795438 A1 CA2795438 A1 CA 2795438A1
Authority
CA
Canada
Prior art keywords
stem cell
determining
antibody
subject
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2795438A
Other languages
English (en)
French (fr)
Inventor
C. Shekhar Mayanil
Shunsuke Ichi
Tadanori Tomita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ann and Robert H Lurie Childrens Hospital of Chicago
Original Assignee
Ann and Robert H Lurie Childrens Hospital of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ann and Robert H Lurie Childrens Hospital of Chicago filed Critical Ann and Robert H Lurie Childrens Hospital of Chicago
Publication of CA2795438A1 publication Critical patent/CA2795438A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/12Post-translational modifications [PTMs] in chemical analysis of biological material alkylation, e.g. methylation, (iso-)prenylation, farnesylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2795438A 2010-05-11 2011-04-21 Method of detecting and profiling progression of the risk of neurodegenerative diseases Abandoned CA2795438A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39532110P 2010-05-11 2010-05-11
US61/395,321 2010-05-11
PCT/US2011/033387 WO2011142952A1 (en) 2010-05-11 2011-04-21 Method of detecting and profiling progression of the risk of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
CA2795438A1 true CA2795438A1 (en) 2011-11-17

Family

ID=44914644

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2795438A Abandoned CA2795438A1 (en) 2010-05-11 2011-04-21 Method of detecting and profiling progression of the risk of neurodegenerative diseases

Country Status (5)

Country Link
US (1) US20130029998A1 (https=)
EP (1) EP2569625A4 (https=)
JP (1) JP2013526705A (https=)
CA (1) CA2795438A1 (https=)
WO (1) WO2011142952A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7118886B2 (ja) 2015-06-03 2022-08-16 エアラン セル テクノロジーズ, インコーポレイテッド 幹細胞からの有益因子の産生および送達のための方法およびデバイス
US10282875B2 (en) 2015-12-11 2019-05-07 International Business Machines Corporation Graph-based analysis for bio-signal event sensing
CN109415431A (zh) 2016-04-20 2019-03-01 爱兰细胞技术公司 与k180二甲基化h1.0蛋白相关的组合物和方法
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
CN111770761B (zh) 2017-10-25 2024-07-09 爱兰细胞技术公司 H1.0k180me2抗体、其制造方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7025A (en) * 1850-01-15 Buckle
US11016A (en) * 1854-06-06 Method of turning hubs
US20050037992A1 (en) * 2003-07-22 2005-02-17 John Lyons Composition and method for treating neurological disorders
CN101909630A (zh) * 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
WO2010001933A1 (ja) * 2008-07-01 2010-01-07 学校法人日本大学 標的遺伝子特異的ヒストン修飾制御剤

Also Published As

Publication number Publication date
WO2011142952A1 (en) 2011-11-17
EP2569625A1 (en) 2013-03-20
EP2569625A4 (en) 2013-12-04
US20130029998A1 (en) 2013-01-31
JP2013526705A (ja) 2013-06-24

Similar Documents

Publication Publication Date Title
Guan et al. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer’s disease
Gibbons et al. Detection of Alzheimer disease (AD)-specific tau pathology in AD and nonAD tauopathies by immunohistochemistry with novel conformation-selective tau antibodies
Hamilton et al. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease
Nijholt et al. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies
Rodríguez-Martín et al. Tau phosphorylation affects its axonal transport and degradation
Regad et al. The tumor suppressor Pml regulates cell fate in the developing neocortex
Aydemir et al. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study
CN103154736B (zh) 用于检测和诊断神经变性疾病的诊断性自身抗体谱
US20130029998A1 (en) Method of Detecting and Profiling Progression of the Risk of Neurodegenerative Diseases
Wenk et al. Altered cholinergic function in the basal forebrain of girls with Rett syndrome
Swenson et al. Senescence in aging and disorders of the central nervous system
EP1339743A2 (en) Compositions and methods for diagnosing alzheimer's disease
JP5642687B2 (ja) 神経学的な自己免疫性障害
Mazzetti et al. Astrocytes expressing Vitamin D‐activating enzyme identify Parkinson’s disease
Min et al. Insulin‐like growth factor I regulates G2/M progression through mammalian target of rapamycin signaling in oligodendrocyte progenitors
Melamud et al. Neuromyelitis Optica Immunoglobulin G present in sera from neuromyelitis optica patients affects aquaporin‐4 expression and water permeability of the astrocyte plasma membrane
Liu et al. Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms
Mukaetova-Ladinska et al. Alpha-and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes
Bernstein et al. Partial loss of parvalbumin‐containing hippocampal interneurons in dementia with Lewy bodies
Teunissen et al. Growth‐associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis
Gong et al. High fat diet aggravates AD-related pathogenic processes in APP/PS1 mice
Costa et al. Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease
US20150025008A1 (en) Compositions and Methods of Detecting and Treating Neural Tube Defects
Iacono et al. Reduced number of pigmented neurons in the substantia nigra of dystonia patients? Findings from extensive neuropathologic, immunohistochemistry, and quantitative analyses
CN105277715A (zh) 巨噬细胞迁移抑制因子(mif)作为早期阿尔茨海默病血清分子标志物

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20160421