CA2794018C - Compositions and methods for the treatment of degenerative diseases - Google Patents
Compositions and methods for the treatment of degenerative diseases Download PDFInfo
- Publication number
- CA2794018C CA2794018C CA2794018A CA2794018A CA2794018C CA 2794018 C CA2794018 C CA 2794018C CA 2794018 A CA2794018 A CA 2794018A CA 2794018 A CA2794018 A CA 2794018A CA 2794018 C CA2794018 C CA 2794018C
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- CA
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- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- administration
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US31718510P | 2010-03-24 | 2010-03-24 | |
| US61/317,185 | 2010-03-24 | ||
| PCT/US2011/029846 WO2011119869A1 (en) | 2010-03-24 | 2011-03-24 | Compositions and methods for the treatment of degenerative diseases |
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| WO (1) | WO2011119869A1 (enExample) |
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| EP2906197A1 (en) | 2012-10-09 | 2015-08-19 | The Procter & Gamble Company | Method of identifying synergistic cosmetic combinations |
| US10302630B2 (en) | 2012-10-09 | 2019-05-28 | The Procter & Gamble Company | Method of identifying or evaluating beneficial actives and compositions containing the same |
| EP3912984A1 (en) | 2012-12-21 | 2021-11-24 | Janssen BioPharma, Inc. | 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv |
| US8921401B2 (en) | 2013-02-07 | 2014-12-30 | Musc Foundation For Research Development | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| US9079853B2 (en) | 2013-02-07 | 2015-07-14 | Musc Foundation For Research Development | Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders |
| CA2905202C (en) | 2013-03-14 | 2019-12-31 | Universite Laval | Use of electroretinography (erg) for the assessment of psychiatric disorders |
| CA2957785C (en) | 2014-08-11 | 2023-01-03 | Angion Biomedica Corporation | Cytochrome p450 inhibitors and uses thereof |
| WO2016109492A1 (en) | 2014-12-31 | 2016-07-07 | Angion Biomedica Corp | Methods and agents for treating disease |
| CN104803946A (zh) * | 2015-03-03 | 2015-07-29 | 佛山市赛维斯医药科技有限公司 | 含腈基噻唑和环戊二烯结构的ptp1b抑制剂及其用途 |
| ES2898922T3 (es) * | 2015-04-30 | 2022-03-09 | Musc Found For Res Dev | Compuestos de oxindol y composiciones farmacéuticas de los mismos |
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| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
| US10967019B2 (en) | 2015-11-30 | 2021-04-06 | Taiwan Mitochondrion Applied Technology Co., Ltd. | Method for protecting mitochondria in retina cell |
| TWI666023B (zh) * | 2016-09-26 | 2019-07-21 | 台灣粒線體應用技術股份有限公司 | 餘甘子萃取物用於製備保護視網膜中粒線體的醫藥組合物的用途 |
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| MD3570834T2 (ro) | 2017-01-11 | 2022-04-30 | Alkermes Inc | Inhibitori biciclici ai histon deacetilazei |
| JP7152471B2 (ja) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス，インコーポレーテッド | ヒストン脱アセチル化酵素の二環阻害剤 |
| CA3133803A1 (en) | 2019-04-11 | 2020-10-15 | Angion Biomedica Corp. | Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole |
| CN115135383B (zh) | 2020-02-18 | 2024-06-11 | 吉利德科学公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
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| EP4128270A4 (en) | 2020-03-26 | 2024-04-03 | Diamentis Inc. | SYSTEMS AND METHODS FOR PROCESSING RETINAL SIGNAL DATA AND IDENTIFYING CONDITIONS |
| JP7688152B2 (ja) | 2021-04-16 | 2025-06-03 | ギリアード サイエンシーズ， インコーポレイテッド | アミドを使用してカルバヌクレオシドを調製する方法 |
| KR20240049311A (ko) | 2021-08-18 | 2024-04-16 | 길리애드 사이언시즈, 인코포레이티드 | 인지질 화합물 및 이의 제조 및 사용 방법 |
| EP4471029A4 (en) * | 2022-01-26 | 2025-05-21 | Suzhou Genhouse Bio Co., Ltd. | Methionine adenosyltransferase 2a inhibitor for treating mtap deletion-type cancer |
| KR20240051860A (ko) * | 2022-10-13 | 2024-04-22 | 한미약품 주식회사 | 신규한 트리사이클 유도체 화합물 및 이의 용도 |
| WO2024127350A1 (en) | 2022-12-16 | 2024-06-20 | Astrazeneca Ab | 2,6,9-trisubstituted purines |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA962269A (en) * | 1971-05-05 | 1975-02-04 | Robert E. Grahame (Jr.) | Thiazoles, and their use as insecticides |
| US3852293A (en) * | 1972-06-21 | 1974-12-03 | Uniroyal Inc | 4-phenyl-2-(3-pyridyl)-thiazole carboxamides |
| JPS57183768A (en) * | 1981-05-06 | 1982-11-12 | Kanto Ishi Pharma Co Ltd | 4-methyl-5-(o-carboxyphenyl)carbamoylthiazole derivative and its preparation |
| US4788207A (en) * | 1988-02-29 | 1988-11-29 | Fmc Corporation | Photoactivated miticidal and insecticidal ethynylthiazoles |
| DE19845402B4 (de) * | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| TWI243164B (en) * | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| CA2450400A1 (en) * | 2001-06-11 | 2002-12-19 | Takeda Chemical Industries, Ltd. | Medicinal compositions |
| ATE415160T1 (de) * | 2002-02-25 | 2008-12-15 | Lilly Co Eli | Modulatoren von peroxisome proliferator- aktivierten rezeptoren |
| PT1511710E (pt) * | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| US20090069301A1 (en) * | 2005-03-03 | 2009-03-12 | Sirtris Pharmaceuticals, Inc. | Acridine and Quinoline Derivatives as Sirtuin Modulators |
| AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| GB0701426D0 (en) * | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| CL2008001822A1 (es) * | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
| RU2007139634A (ru) * | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| US20110124649A1 (en) * | 2007-11-09 | 2011-05-26 | The Johns Hopkins University | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
-
2011
- 2011-03-24 JP JP2013501494A patent/JP2013522376A/ja active Pending
- 2011-03-24 US US13/636,754 patent/US20130137728A1/en not_active Abandoned
- 2011-03-24 EP EP11715106A patent/EP2550260A1/en not_active Withdrawn
- 2011-03-24 AU AU2011232347A patent/AU2011232347B2/en not_active Ceased
- 2011-03-24 CA CA2794018A patent/CA2794018C/en not_active Expired - Fee Related
- 2011-03-24 WO PCT/US2011/029846 patent/WO2011119869A1/en not_active Ceased
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2015
- 2015-09-28 JP JP2015189524A patent/JP2015232051A/ja active Pending
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2016
- 2016-01-15 US US14/996,662 patent/US20160237074A1/en not_active Abandoned
- 2016-08-09 JP JP2016156126A patent/JP2016188257A/ja active Pending
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|---|---|
| AU2011232347B2 (en) | 2015-08-06 |
| JP2015232051A (ja) | 2015-12-24 |
| CA2794018A1 (en) | 2011-09-29 |
| JP2016188257A (ja) | 2016-11-04 |
| JP2013522376A (ja) | 2013-06-13 |
| AU2011232347A1 (en) | 2012-10-04 |
| US20160237074A1 (en) | 2016-08-18 |
| WO2011119869A1 (en) | 2011-09-29 |
| US20130137728A1 (en) | 2013-05-30 |
| EP2550260A1 (en) | 2013-01-30 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180326 |