CA2793586A1 - Methods for identifying inhibitors of the type iii secretion system - Google Patents

Methods for identifying inhibitors of the type iii secretion system Download PDF

Info

Publication number
CA2793586A1
CA2793586A1 CA2793586A CA2793586A CA2793586A1 CA 2793586 A1 CA2793586 A1 CA 2793586A1 CA 2793586 A CA2793586 A CA 2793586A CA 2793586 A CA2793586 A CA 2793586A CA 2793586 A1 CA2793586 A1 CA 2793586A1
Authority
CA
Canada
Prior art keywords
effector
component
protein
secretion
t3ss
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2793586A
Other languages
English (en)
French (fr)
Inventor
Thomas C. Marlovits
Julia Radics
Wolfgang Schmied
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Molecular Biotechnology
Original Assignee
Institute of Molecular Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Molecular Biotechnology filed Critical Institute of Molecular Biotechnology
Publication of CA2793586A1 publication Critical patent/CA2793586A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2793586A 2010-03-23 2011-03-22 Methods for identifying inhibitors of the type iii secretion system Abandoned CA2793586A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10157397.0 2010-03-23
EP10157397 2010-03-23
PCT/EP2011/054379 WO2011117259A1 (en) 2010-03-23 2011-03-22 Methods for identifying inhibitors of the type iii secretion system

Publications (1)

Publication Number Publication Date
CA2793586A1 true CA2793586A1 (en) 2011-09-29

Family

ID=42199515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2793586A Abandoned CA2793586A1 (en) 2010-03-23 2011-03-22 Methods for identifying inhibitors of the type iii secretion system

Country Status (7)

Country Link
US (1) US20130130283A1 (enExample)
EP (1) EP2550366B1 (enExample)
JP (1) JP5714692B2 (enExample)
CA (1) CA2793586A1 (enExample)
DK (1) DK2550366T3 (enExample)
ES (1) ES2526316T3 (enExample)
WO (1) WO2011117259A1 (enExample)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
CA2252372C (en) * 1996-04-23 2010-06-29 B. Brett Finlay Pathogenic escherichia coli associated protein
WO1999045136A1 (en) 1998-03-05 1999-09-10 University Of British Columbia Methods for assaying type iii secretion inhibitors
US6248546B1 (en) * 1998-03-09 2001-06-19 Diagnostic Systems Laboratories, Inc. Assay of IGFBP complex
GB0112687D0 (en) * 2001-05-24 2001-07-18 Microbiological Res Authority Pharmaceutical use of secreted bacterial effector proteins
GB0304993D0 (en) * 2003-03-05 2003-04-09 Univ Nottingham Trent Novel screening method
WO2005113791A2 (en) 2004-05-07 2005-12-01 Johnson & Johnson Product Research And Development Methods of identifying modulators of bacterial type iii protein secretion system
EP1795609A1 (en) * 2005-12-06 2007-06-13 Sanofi-Aventis Deutschland GmbH Method for the diagnosis and treatment of cardiovascular diseases
CA2563214A1 (en) * 2006-10-12 2008-04-12 Institut Pasteur Shigella ipad protein and its use as a potential vaccine against shigella infection
WO2009061491A2 (en) 2007-11-07 2009-05-14 University Of Massachusetts Type iii secretion inhibitors and uses thereof
US8716283B2 (en) 2007-11-07 2014-05-06 University Of Massachusetts Type III secretion inhibitors, analogs and uses thereof
WO2009137133A2 (en) 2008-02-14 2009-11-12 University Of Washington 5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection

Also Published As

Publication number Publication date
WO2011117259A1 (en) 2011-09-29
JP2013522638A (ja) 2013-06-13
EP2550366B1 (en) 2014-11-12
EP2550366A1 (en) 2013-01-30
US20130130283A1 (en) 2013-05-23
WO2011117259A9 (en) 2011-11-24
ES2526316T3 (es) 2015-01-09
JP5714692B2 (ja) 2015-05-07
DK2550366T3 (en) 2014-12-15

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170322