CA2791538C - Oligomer-specific amyloid beta epitope and antibodies - Google Patents
Oligomer-specific amyloid beta epitope and antibodies Download PDFInfo
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- CA2791538C CA2791538C CA2791538A CA2791538A CA2791538C CA 2791538 C CA2791538 C CA 2791538C CA 2791538 A CA2791538 A CA 2791538A CA 2791538 A CA2791538 A CA 2791538A CA 2791538 C CA2791538 C CA 2791538C
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31016710P | 2010-03-03 | 2010-03-03 | |
| US61/310,167 | 2010-03-03 | ||
| PCT/CA2011/000238 WO2011106885A1 (en) | 2010-03-03 | 2011-03-03 | Oligomer-specific amyloid beta epitope and antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2791538A1 CA2791538A1 (en) | 2011-09-09 |
| CA2791538C true CA2791538C (en) | 2019-04-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2791538A Expired - Fee Related CA2791538C (en) | 2010-03-03 | 2011-03-03 | Oligomer-specific amyloid beta epitope and antibodies |
Country Status (17)
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| US (3) | US9216217B2 (OSRAM) |
| EP (2) | EP2542571B1 (OSRAM) |
| JP (2) | JP6190113B2 (OSRAM) |
| KR (1) | KR101831459B1 (OSRAM) |
| CN (1) | CN102858796B (OSRAM) |
| AU (1) | AU2011223456A1 (OSRAM) |
| BR (1) | BR112012022229A2 (OSRAM) |
| CA (1) | CA2791538C (OSRAM) |
| CL (1) | CL2012002438A1 (OSRAM) |
| CO (1) | CO6640211A2 (OSRAM) |
| IL (1) | IL221695B (OSRAM) |
| MX (1) | MX341536B (OSRAM) |
| NZ (1) | NZ602548A (OSRAM) |
| RU (1) | RU2644335C2 (OSRAM) |
| SG (1) | SG183854A1 (OSRAM) |
| WO (1) | WO2011106885A1 (OSRAM) |
| ZA (1) | ZA201206916B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2542571B1 (en) | 2010-03-03 | 2016-05-25 | The University of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| TWI571207B (zh) | 2011-06-26 | 2017-02-21 | 安麗托克斯公司 | 用於條件化動物飼料之寒冷天氣調配物 |
| CN104093454A (zh) * | 2011-11-10 | 2014-10-08 | 坎格尼美国股份有限公司 | 治疗阿耳茨海默氏病的组合物和方法 |
| EP2834644B1 (de) * | 2012-04-05 | 2019-08-21 | Forschungszentrum Jülich GmbH | Polymere, enthaltend multivalente amyloid-beta-bindende d-peptide und deren verwendung |
| CA2938129A1 (en) * | 2014-02-03 | 2015-08-06 | Cangene Corporation | Humanized beta-amyloid binding molecules and uses thereof |
| WO2016008047A1 (en) * | 2014-07-14 | 2016-01-21 | Cangene Corporation | Cyclic peptide vaccination for treatment of amyloid beta-related disorders |
| EP3374379A4 (en) * | 2015-11-09 | 2019-05-15 | The University Of British Columbia | N-TERMINAL EPITOPES IN AMYLOID BETA AND CONFORMATION-SELECTIVE ANTIBODIES |
| US20180326027A1 (en) * | 2015-11-09 | 2018-11-15 | The University Of British Columbia | Epitopes in amyloid beta and conformationally-selective antibodies thereto |
| JP7448174B2 (ja) * | 2015-11-09 | 2024-03-12 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | アミロイドベータ中間領域エピトープおよびそれに対する立体配座選択的抗体 |
| US11756650B2 (en) | 2015-11-09 | 2023-09-12 | The University Of British Columbia | Systems and methods for predicting misfolded protein epitopes by collective coordinate biasing |
| CA3004498A1 (en) * | 2015-11-09 | 2017-05-18 | Neil R. Cashman | Amyloid beta epitopes and antibodies thereto |
| KR102550991B1 (ko) | 2016-07-18 | 2023-07-04 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타에 대한 항체 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| CN112839710B (zh) * | 2018-08-09 | 2024-09-17 | 霍夫曼-拉罗奇有限公司 | 帕金森氏病的确定 |
| EP3861015A4 (en) * | 2018-10-07 | 2022-11-23 | The University of British Columbia | CONFORMATION SPECIFIC EPITOPES IN ALPHA-SYNUCLEIN, ANTIBODIES DIRECTED AGAINST AND METHODS THEREOF |
| CA3127113A1 (en) | 2019-01-30 | 2020-08-06 | Dongxu Sun | Anti-gal3 antibodies and uses thereof |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| AU2021278935A1 (en) | 2020-05-26 | 2022-12-08 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
| US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
| WO1997037228A1 (en) | 1996-03-29 | 1997-10-09 | The Trustees Of Boston University | Methods for diagnosing and treating alzheimer's disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7252952B2 (en) | 2000-03-06 | 2007-08-07 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein—protein interaction |
| US6686443B1 (en) | 2000-05-26 | 2004-02-03 | The Regents Of The University Of California | Chemical reagents for formation of disulfide bonds in peptides |
| DE04759123T1 (de) | 2003-04-07 | 2005-08-18 | Novetide Ltd. | Verfahren zur herstellung cyclischer peptide |
| EP1484336A1 (en) | 2003-06-02 | 2004-12-08 | Pevion Biotech Ltd. | Methods for synthesizing conformationally constrained peptides, peptidometics and the use thereof as synthetic vaccines |
| WO2006047254A1 (en) * | 2004-10-22 | 2006-05-04 | Regents Of The University Of Minnesota | Assemblies of oligomeric amyloid beta protein and uses thereof |
| IL169622A0 (en) | 2005-07-11 | 2007-07-04 | Yeda Res & Dev | Methods of screening modulators of interleukin-32 (il-32)modulators of il-32 identified by said methods and their use |
| AU2006270245A1 (en) * | 2005-07-13 | 2007-01-25 | Coimmune Inc. | Catalytic immunoglobulins |
| AU2007223427A1 (en) | 2006-03-01 | 2007-09-13 | University Of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| KR101528939B1 (ko) | 2006-07-18 | 2015-06-15 | 사노피 | 암 치료를 위한 ｅｐｈａ2에 대한 길항제 항체 |
| RU2546234C2 (ru) | 2008-07-01 | 2015-04-10 | Де Стат Дер Недерланден, Верт.Дор Де Министер Ван Ввс | Вакцина против интермедиата с амилоидным сворачиванием |
| WO2010010469A2 (en) | 2008-07-25 | 2010-01-28 | Abbott Gmbh & Co. Kg | Abeta (x-38..43) oligomers, and processes, compositions, and uses thereof |
| EP2303920A4 (en) * | 2008-07-25 | 2011-11-09 | Abbott Lab | SS-AMYLOID PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PREPARATION METHODS AND COMPOSITIONS COMPRISING THE SAME OR OLIGOMERIC ANALOGUES, AND USES THEREOF |
| US8410243B2 (en) | 2008-12-17 | 2013-04-02 | The Governors Of The University Of Alberta | Aromatic ether-containing fluorene monomers, processes for their preparation and polymerization thereof |
| EP2379504A2 (en) | 2008-12-22 | 2011-10-26 | Sloan Kettering Institute For Cancer Research | Coumarin-based compounds |
| MX2012008840A (es) | 2010-02-09 | 2012-09-07 | Squibb Bristol Myers Co | Estandares para inmunoensayos y medicion de biomarcadores clinicos usando estandares de calibracion intra-ensayos. |
| EP2542571B1 (en) | 2010-03-03 | 2016-05-25 | The University of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| US9320793B2 (en) | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| CN104093454A (zh) | 2011-11-10 | 2014-10-08 | 坎格尼美国股份有限公司 | 治疗阿耳茨海默氏病的组合物和方法 |
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2011
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- 2011-03-03 CN CN201180020228.1A patent/CN102858796B/zh not_active Expired - Fee Related
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- 2011-03-03 WO PCT/CA2011/000238 patent/WO2011106885A1/en not_active Ceased
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| MX2012010175A (es) | 2012-11-23 |
| CN102858796A (zh) | 2013-01-02 |
| US20140314773A1 (en) | 2014-10-23 |
| US20160228522A1 (en) | 2016-08-11 |
| WO2011106885A1 (en) | 2011-09-09 |
| US9849165B2 (en) | 2017-12-26 |
| JP6190113B2 (ja) | 2017-08-30 |
| KR101831459B1 (ko) | 2018-04-04 |
| US9216217B2 (en) | 2015-12-22 |
| CO6640211A2 (es) | 2013-03-22 |
| CA2791538A1 (en) | 2011-09-09 |
| NZ602548A (en) | 2014-12-24 |
| RU2012139043A (ru) | 2014-04-10 |
| JP2013524774A (ja) | 2013-06-20 |
| EP2542571A1 (en) | 2013-01-09 |
| AU2011223456A1 (en) | 2012-10-18 |
| EP3056510A1 (en) | 2016-08-17 |
| EP2542571B1 (en) | 2016-05-25 |
| EP2542571A4 (en) | 2013-07-31 |
| RU2644335C2 (ru) | 2018-02-08 |
| SG183854A1 (en) | 2012-10-30 |
| ZA201206916B (en) | 2014-03-26 |
| JP6494565B2 (ja) | 2019-04-03 |
| KR20130045850A (ko) | 2013-05-06 |
| JP2016193914A (ja) | 2016-11-17 |
| BR112012022229A2 (pt) | 2016-07-05 |
| IL221695B (en) | 2019-01-31 |
| EP3056510B1 (en) | 2018-10-03 |
| CN102858796B (zh) | 2016-05-11 |
| CL2012002438A1 (es) | 2013-09-13 |
| US20130084283A1 (en) | 2013-04-04 |
| MX341536B (es) | 2016-08-24 |
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| EEER | Examination request |
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| MKLA | Lapsed |
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| MKLA | Lapsed |
Effective date: 20200303 |