CA2789252C - Streptococcus pyogenes antigens and corresponding dna fragments - Google Patents

Info

Publication number

CA2789252C

CA2789252C CA2789252A CA2789252A CA2789252C CA 2789252 C CA2789252 C CA 2789252C CA 2789252 A CA2789252 A CA 2789252A CA 2789252 A CA2789252 A CA 2789252A CA 2789252 C CA2789252 C CA 2789252C

Authority

CA

Canada

Prior art keywords

polypeptide

ala

gly

lys

val

Prior art date

2000-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 241000193996 Streptococcus pyogenes Species 0.000 title claims abstract description 140
• 108091007433 antigens Proteins 0.000 title claims abstract description 34
• 102000036639 antigens Human genes 0.000 title claims abstract description 34
• 239000000427 antigen Substances 0.000 title claims abstract description 33
• 239000012634 fragment Substances 0.000 title claims description 75
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 291
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 290
• 229920001184 polypeptide Polymers 0.000 claims abstract description 289
• 108091033319 polynucleotide Proteins 0.000 claims abstract description 63
• 102000040430 polynucleotide Human genes 0.000 claims abstract description 63
• 239000002157 polynucleotide Substances 0.000 claims abstract description 63
• 238000011321 prophylaxis Methods 0.000 claims abstract description 9
• 108090000623 proteins and genes Proteins 0.000 claims description 63
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
• 238000000034 method Methods 0.000 claims description 45
• 230000028993 immune response Effects 0.000 claims description 28
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• 239000013598 vector Substances 0.000 claims description 23
• 125000000539 amino acid group Chemical group 0.000 claims description 22
• 230000027455 binding Effects 0.000 claims description 21
• 239000008194 pharmaceutical composition Substances 0.000 claims description 21
• 230000002163 immunogen Effects 0.000 claims description 20
• 239000000203 mixture Substances 0.000 claims description 18
• 102000004169 proteins and genes Human genes 0.000 claims description 18
• 239000012472 biological sample Substances 0.000 claims description 17
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• 230000014509 gene expression Effects 0.000 claims description 13
• 150000001413 amino acids Chemical class 0.000 claims description 12
• 241000282414 Homo sapiens Species 0.000 claims description 11
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• 239000003085 diluting agent Substances 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 230000001939 inductive effect Effects 0.000 claims description 7
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• 239000003937 drug carrier Substances 0.000 claims description 5
• 230000008569 process Effects 0.000 claims description 5
• 108010078791 Carrier Proteins Proteins 0.000 claims description 4
• 102000014914 Carrier Proteins Human genes 0.000 claims description 4
• 241000124008 Mammalia Species 0.000 claims description 4
• 230000003248 secreting effect Effects 0.000 claims description 4
• 241001529936 Murinae Species 0.000 claims description 3
• 238000012258 culturing Methods 0.000 claims description 3
• 108010077805 Bacterial Proteins Proteins 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 1
• 241001505901 Streptococcus sp. 'group A' Species 0.000 abstract description 4
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• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 8
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 8
• HYIFFZAQXPUEAU-QWRGUYRKSA-N Leu-Gly-Leu Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC(C)C HYIFFZAQXPUEAU-QWRGUYRKSA-N 0.000 description 8
• BTWMICVCQLKKNR-DCAQKATOSA-N Val-Leu-Ser Chemical compound CC(C)[C@H]([NH3+])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C([O-])=O BTWMICVCQLKKNR-DCAQKATOSA-N 0.000 description 8
• 108010081404 acein-2 Proteins 0.000 description 8
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• 108010010096 glycyl-glycyl-tyrosine Proteins 0.000 description 8
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• 238000000746 purification Methods 0.000 description 8
• 108010072986 threonyl-seryl-lysine Proteins 0.000 description 8
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• SNAKIVFVLVUCKB-UHFFFAOYSA-N Asn-Glu-Ala-Lys Natural products NCCCCC(C(O)=O)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(N)CC(N)=O SNAKIVFVLVUCKB-UHFFFAOYSA-N 0.000 description 7
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