CA2788783C - Heterocycles as potassium channel modulators - Google Patents
Heterocycles as potassium channel modulators Download PDFInfo
- Publication number
- CA2788783C CA2788783C CA2788783A CA2788783A CA2788783C CA 2788783 C CA2788783 C CA 2788783C CA 2788783 A CA2788783 A CA 2788783A CA 2788783 A CA2788783 A CA 2788783A CA 2788783 C CA2788783 C CA 2788783C
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- CA
- Canada
- Prior art keywords
- pyridin
- imidazo
- fluoro
- trifluoromethyl
- pain
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- 108020001213 potassium channel Proteins 0.000 title claims abstract description 74
- 102000004257 Potassium Channel Human genes 0.000 title claims abstract description 73
- 125000000623 heterocyclic group Chemical group 0.000 title abstract description 6
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 46
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- BPMXKSZIVZAGJP-UHFFFAOYSA-N n-[3-cyclobutyl-6-(trifluoromethyl)imidazo[1,2-b]pyridazin-2-yl]-3,3,3-trifluoro-2,2-dimethylpropanamide Chemical compound FC(F)(F)C(C)(C)C(=O)NC=1N=C2C=CC(C(F)(F)F)=NN2C=1C1CCC1 BPMXKSZIVZAGJP-UHFFFAOYSA-N 0.000 claims 1
- XUNJIMLWMVGTSK-UHFFFAOYSA-N n-[3-cyclobutyl-6-(trifluoromethyl)imidazo[1,2-b]pyridazin-2-yl]-4,4,4-trifluoro-3,3-dimethylbutanamide Chemical compound FC(F)(F)C(C)(C)CC(=O)NC=1N=C2C=CC(C(F)(F)F)=NN2C=1C1CCC1 XUNJIMLWMVGTSK-UHFFFAOYSA-N 0.000 claims 1
- HAMPHMHYVVBIAN-UHFFFAOYSA-N n-[3-cyclopentyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-4,4,4-trifluoro-3,3-dimethylbutanamide Chemical compound FC(F)(F)C(C)(C)CC(=O)NC=1N=C2C=CC(C(F)(F)F)=CN2C=1C1CCCC1 HAMPHMHYVVBIAN-UHFFFAOYSA-N 0.000 claims 1
- YREYHQNMOUCMQS-UHFFFAOYSA-N n-[3-cyclopropyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-4,4,4-trifluoro-3,3-dimethylbutanamide Chemical compound FC(F)(F)C(C)(C)CC(=O)NC=1N=C2C=CC(C(F)(F)F)=CN2C=1C1CC1 YREYHQNMOUCMQS-UHFFFAOYSA-N 0.000 claims 1
- WWDNCUUKKLRWDQ-UHFFFAOYSA-N n-[3-cyclopropyl-6-(trifluoromethyl)imidazo[1,2-b]pyridazin-2-yl]-3,3,3-trifluoro-2,2-dimethylpropanamide Chemical compound FC(F)(F)C(C)(C)C(=O)NC=1N=C2C=CC(C(F)(F)F)=NN2C=1C1CC1 WWDNCUUKKLRWDQ-UHFFFAOYSA-N 0.000 claims 1
- HJHYTJIDVLJSPN-UHFFFAOYSA-N n-[3-cyclopropyl-6-(trifluoromethyl)imidazo[1,2-b]pyridazin-2-yl]-3,4-difluorobenzamide Chemical compound C1=C(F)C(F)=CC=C1C(=O)NC1=C(C2CC2)N2N=C(C(F)(F)F)C=CC2=N1 HJHYTJIDVLJSPN-UHFFFAOYSA-N 0.000 claims 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/706,574 | 2010-02-16 | ||
| US12/706,574 US8431608B2 (en) | 2007-08-17 | 2010-02-16 | Heterocycles as potassium channel modulators |
| PCT/US2011/023444 WO2011102964A1 (en) | 2010-02-16 | 2011-02-02 | Heterocycles as potassium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2788783A1 CA2788783A1 (en) | 2011-08-25 |
| CA2788783C true CA2788783C (en) | 2014-06-03 |
Family
ID=43734000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2788783A Expired - Fee Related CA2788783C (en) | 2010-02-16 | 2011-02-02 | Heterocycles as potassium channel modulators |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8431608B2 (https=) |
| EP (1) | EP2536718A1 (https=) |
| JP (1) | JP2013519728A (https=) |
| CA (1) | CA2788783C (https=) |
| WO (1) | WO2011102964A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2400604T3 (es) * | 2007-08-17 | 2013-04-11 | Icagen, Inc. | Heterociclos como moduladores del canal de potasio |
| MD20170011A2 (ro) * | 2014-08-06 | 2017-08-31 | Pfizer Inc. | Compuşi imidazopiridazinici |
| AR104315A1 (es) * | 2015-04-21 | 2017-07-12 | Glaxosmithkline Ip Dev Ltd | Compuestos de butanamida, sal farmacéuticamente aceptable del mismo, composición farmacéutica que lo comprende, su uso para prepararla, y combinación y mezcla que lo comprenden |
| AU2016342027B2 (en) * | 2015-10-23 | 2021-05-13 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| SG11201811023UA (en) | 2016-06-23 | 2019-01-30 | St Jude Childrens Res Hospital | Small molecule modulators of pantothenate kinases |
| US10183972B2 (en) | 2016-07-14 | 2019-01-22 | University Of South Florida | BK channel-modulating peptides and their use |
| AR110922A1 (es) * | 2017-02-06 | 2019-05-15 | Gilead Sciences Inc | Compuestos inhibidores del vih |
| PL3615019T3 (pl) | 2017-04-26 | 2026-01-19 | Navitor Pharmaceuticals, Inc. | Modulator interakcji sestryna-gator2 do zastosowania w leczeniu depresji opornej na leczenie |
| US11370769B2 (en) | 2017-09-07 | 2022-06-28 | Board Of Regents Of The University Of Nebraska | TRPC5 inhibitors and methods of using same |
| WO2019133635A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital | Small molecule modulators of pantothenate kinases |
| EP3870158A4 (en) | 2018-10-24 | 2022-08-10 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
| WO2020198526A2 (en) * | 2019-03-27 | 2020-10-01 | St. Jude Children's Research Hospital | Small molecule modulators of pank |
| US11723890B2 (en) | 2019-11-01 | 2023-08-15 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mTORC1 modulator |
| WO2023133256A1 (en) * | 2022-01-07 | 2023-07-13 | Biohaven Therapeutics Ltd. | Pyrazolo[1,5-a]pyridin-2,3-yl amides as kv7 channel activators |
| WO2025067461A1 (zh) * | 2023-09-28 | 2025-04-03 | 南京明德新药研发有限公司 | 杂芳基衍生物及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3701780A (en) | 1970-09-18 | 1972-10-31 | Merck & Co Inc | Imidazo(1,2-a)pyridines |
| US4096264A (en) | 1975-12-09 | 1978-06-20 | Merck & Co., Inc. | Certain substituted imidazo [1,2-a] pyridines |
| GB8719368D0 (en) | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
| JPH0168375U (https=) | 1987-10-23 | 1989-05-02 | ||
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| CA2311483A1 (en) | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| JP2004517080A (ja) | 2000-11-29 | 2004-06-10 | グラクソ グループ リミテッド | Ｔｉｅ−２および／またはｖｅｇｆｒ−２の阻害剤として有用なベンゾイミダゾール誘導体 |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| CA2504735C (en) | 2002-11-07 | 2009-06-23 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| ES2328047T3 (es) | 2004-03-19 | 2009-11-06 | Warner-Lambert Company Llc | Derivados de imidazopiridina e imidazopirimidina como agentes antibacterianos. |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| WO2007056075A2 (en) | 2005-11-02 | 2007-05-18 | Targegen, Inc. | Six membered heteroaromatic inhibitors targeting resistant kinase mutations |
| PE20070978A1 (es) | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| KR20070115502A (ko) | 2006-06-02 | 2007-12-06 | 파크시스템스 주식회사 | 주사 탐침 현미경 및 이를 이용한 측정방법 |
| AU2007279595A1 (en) | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivative and use thereof |
| EP2058309A4 (en) | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
| CN101594909A (zh) | 2006-09-07 | 2009-12-02 | 比奥根艾迪克Ma公司 | 用于治疗炎性病症、细胞增殖性失调、免疫失调的irak调节剂 |
| ES2400604T3 (es) * | 2007-08-17 | 2013-04-11 | Icagen, Inc. | Heterociclos como moduladores del canal de potasio |
| AU2008343813B2 (en) | 2007-12-19 | 2012-04-12 | Amgen Inc. | Inhibitors of PI3 kinase |
| WO2009136663A1 (en) | 2008-05-08 | 2009-11-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
-
2010
- 2010-02-16 US US12/706,574 patent/US8431608B2/en not_active Expired - Fee Related
-
2011
- 2011-02-02 EP EP11703344A patent/EP2536718A1/en not_active Withdrawn
- 2011-02-02 CA CA2788783A patent/CA2788783C/en not_active Expired - Fee Related
- 2011-02-02 JP JP2012553927A patent/JP2013519728A/ja active Pending
- 2011-02-02 WO PCT/US2011/023444 patent/WO2011102964A1/en not_active Ceased
-
2013
- 2013-02-01 US US13/756,759 patent/US9018208B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9018208B2 (en) | 2015-04-28 |
| US20130143889A1 (en) | 2013-06-06 |
| US8431608B2 (en) | 2013-04-30 |
| CA2788783A1 (en) | 2011-08-25 |
| JP2013519728A (ja) | 2013-05-30 |
| EP2536718A1 (en) | 2012-12-26 |
| WO2011102964A1 (en) | 2011-08-25 |
| US20100240663A1 (en) | 2010-09-23 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180202 |