CA2788455C - Mass analysis system with low pressure differential mobility spectrometer - Google Patents
Mass analysis system with low pressure differential mobility spectrometer Download PDFInfo
- Publication number
- CA2788455C CA2788455C CA2788455A CA2788455A CA2788455C CA 2788455 C CA2788455 C CA 2788455C CA 2788455 A CA2788455 A CA 2788455A CA 2788455 A CA2788455 A CA 2788455A CA 2788455 C CA2788455 C CA 2788455C
- Authority
- CA
- Canada
- Prior art keywords
- ions
- dms
- ion
- region
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29908610P | 2010-01-28 | 2010-01-28 | |
| US61/299,086 | 2010-01-28 | ||
| PCT/US2011/022905 WO2011094529A2 (en) | 2010-01-28 | 2011-01-28 | Mass analysis system with low pressure differential mobility spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2788455A1 CA2788455A1 (en) | 2011-08-04 |
| CA2788455C true CA2788455C (en) | 2019-05-21 |
Family
ID=44309254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2788455A Expired - Fee Related CA2788455C (en) | 2010-01-28 | 2011-01-28 | Mass analysis system with low pressure differential mobility spectrometer |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110183431A1 (https=) |
| EP (1) | EP2529387B1 (https=) |
| JP (1) | JP5985989B2 (https=) |
| CA (1) | CA2788455C (https=) |
| WO (1) | WO2011094529A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8217342B2 (en) * | 2009-01-14 | 2012-07-10 | Sociedad Europea de Analisis Diferencial de Movilidad | Ionizer for vapor analysis decoupling the ionization region from the analyzer |
| US8941054B2 (en) * | 2011-04-26 | 2015-01-27 | Bruker Daltonik Gmbh | Selective ion mobility spectrometer formed from two consecutive mass selective filters |
| WO2012167254A1 (en) * | 2011-06-03 | 2012-12-06 | Dh Technologies Development Pte. Ltd. | Method and system for reducing interferences in the spectrometric analysis of steroids |
| WO2013061141A1 (en) * | 2011-10-26 | 2013-05-02 | Dh Technologies Development Pte. Ltd. | Apparatus and method for fractionation |
| GB2509412B (en) | 2012-02-21 | 2016-06-01 | Thermo Fisher Scient (Bremen) Gmbh | Apparatus and methods for ion mobility spectrometry |
| US9070542B2 (en) | 2012-04-06 | 2015-06-30 | Implant Sciences Corporation | Selective ionization using high frequency filtering of reactive ions |
| WO2013171569A1 (en) * | 2012-05-18 | 2013-11-21 | Dh Technologies Development Pte. Ltd. | Reducing interferences in isobaric tag-based quantification |
| EP2850644B1 (en) * | 2012-05-18 | 2018-10-31 | DH Technologies Development Pte. Ltd. | Modulation of instrument resolution dependant upon the complexity of a previous scan |
| GB2508574B (en) * | 2012-06-24 | 2014-12-17 | Fasmatech Science And Technology Sa | Improvements in and relating to the control of ions |
| GB2517670B (en) * | 2013-03-15 | 2020-04-29 | Smiths Detection Watford Ltd | Ion modification |
| US9564302B2 (en) * | 2013-06-21 | 2017-02-07 | Dh Technologies Development Pte. Ltd. | Contamination filter for mass spectrometer |
| JP6015863B2 (ja) * | 2013-08-08 | 2016-10-26 | 株式会社島津製作所 | 三連四重極型質量分析装置 |
| US9390898B1 (en) * | 2013-08-30 | 2016-07-12 | Leidos, Inc. | System and method for fusing chemical detectors |
| US9057699B2 (en) | 2013-11-21 | 2015-06-16 | Hamilton Sundstrand Corporation | High temperature differential ion mobility spectroscopy |
| US9362098B2 (en) * | 2013-12-24 | 2016-06-07 | Waters Technologies Corporation | Ion optical element |
| JP6231219B2 (ja) | 2013-12-24 | 2017-11-15 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 電気的に接地された電気スプレーための大気インターフェース |
| CN105874331A (zh) * | 2013-12-31 | 2016-08-17 | Dh科技发展私人贸易有限公司 | 使用高效离子导向器的真空dms |
| JP6549130B2 (ja) * | 2013-12-31 | 2019-07-24 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 微分移動度分光計のための噴射注入器入口 |
| US10371665B2 (en) * | 2014-06-06 | 2019-08-06 | Micromass Uk Limited | Mobility selective attenuation |
| GB201410369D0 (en) * | 2014-06-11 | 2014-07-23 | Micromass Ltd | Monitoring IMS environment for improved CCS accuracy and precision |
| EP3961202A1 (en) | 2014-06-11 | 2022-03-02 | Micromass UK Limited | Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision |
| WO2015189545A1 (en) * | 2014-06-11 | 2015-12-17 | Micromass Uk Limited | Ion mobility spectrometry data directed acquisition |
| EP4040147A1 (en) * | 2014-06-16 | 2022-08-10 | Purdue Research Foundation | Sample analysis systems and methods of use thereof |
| WO2016020788A1 (en) * | 2014-08-05 | 2016-02-11 | Dh Technologies Development Pte. Ltd. | Methods for distinguishing dioleinates of aged and non-aged olive oil |
| GB2531285B (en) | 2014-10-14 | 2017-07-26 | Smiths Detection-Watford Ltd | Ion mobility spectrometer with ion modification |
| WO2016063236A1 (en) * | 2014-10-22 | 2016-04-28 | Dh Technologies Development Pte.Ltd. | Methods and systems for cross-talk elimination in continuous beam mobility-based spectrometers |
| US10345261B2 (en) * | 2014-12-31 | 2019-07-09 | Dh Technologies Development Pte. Ltd. | Differential mobility spectrometry method |
| US20180033598A1 (en) * | 2015-02-06 | 2018-02-01 | Dh Technologies Development Pte. Ltd. | Lipid Screening Platform Allowing a Complete Solution for Lipidomics Research |
| CN104637777B (zh) * | 2015-02-16 | 2017-05-17 | 江苏天瑞仪器股份有限公司 | 一种质谱仪反吹气结构 |
| CN104833761B (zh) * | 2015-06-01 | 2017-04-26 | 华质泰科生物技术（北京）有限公司 | 一种快速分析样品中的糖类化合物的方法 |
| US9607817B1 (en) | 2015-09-11 | 2017-03-28 | Thermo Finnigan Llc | Systems and methods for ion separation |
| WO2017089045A1 (en) * | 2015-11-27 | 2017-06-01 | Shimadzu Corporation | Ion transfer apparatus |
| US10541122B2 (en) | 2017-06-13 | 2020-01-21 | Mks Instruments, Inc. | Robust ion source |
| US11424114B2 (en) * | 2017-11-28 | 2022-08-23 | Dh Technologies Development Pte. Ltd. | Predicting molecular collision cross-section using differential mobility spectrometry |
| CN111758146A (zh) | 2018-01-17 | 2020-10-09 | Dh科技发展私人贸易有限公司 | 用于提高msms置信度的dm-swath获取 |
| US10467362B2 (en) * | 2018-01-19 | 2019-11-05 | Nikolai Kislov | Analytical tools and methods for modeling transport processes in fluids |
| US11874251B2 (en) * | 2018-02-13 | 2024-01-16 | Jp Scientific Limited | Ion mobility spectrometer and method of analyzing ions |
| WO2019236139A1 (en) * | 2018-06-04 | 2019-12-12 | The Trustees Of Indiana University | Interface for transporting ions from an atmospheric pressure environment to a low pressure environment |
| US10663428B2 (en) | 2018-06-29 | 2020-05-26 | Thermo Finnigan Llc | Systems and methods for ion separation using IMS-MS with multiple ion exits |
| US10663430B2 (en) * | 2018-08-08 | 2020-05-26 | Thermo Finnigan Llc | Quantitation throughput enhancement by differential mobility based pre-separation |
| CN109065435A (zh) * | 2018-08-28 | 2018-12-21 | 山东省分析测试中心 | 一种微电离喷雾离子源差分离子迁移谱及其应用方法 |
| EP4018469A1 (en) * | 2019-08-21 | 2022-06-29 | DH Technologies Development Pte. Ltd. | Apparatus and methods for thermal dissociation in a mass spectrometry system |
| US11293898B2 (en) | 2020-02-06 | 2022-04-05 | Thermo Finnigan Llc | Duty cycle improvement for a mass spectrometer using ion mobility separation |
| GB202004961D0 (en) | 2020-04-03 | 2020-05-20 | Micromass Ltd | De-clustering guide |
| GB2597575B (en) * | 2020-05-29 | 2024-05-01 | Bruker Scient Llc | Electrospray ion source for spectrometry using inductively heated gas |
| US11273465B1 (en) * | 2020-09-17 | 2022-03-15 | Desaraju Subrahmanyam | Tunable electrostatic ion and fluid flow generator and electroacoustic transducer |
| US20220397552A1 (en) * | 2021-06-10 | 2022-12-15 | GP Ionics LLC | Molecular identification using field induced fragmentation spectra by reactive stage tandem differential mobility spectrometry |
| US20240282564A1 (en) * | 2021-06-22 | 2024-08-22 | Dh Technologies Development Pte. Ltd. | Automated systems and methods for separating compounds |
| US12235239B2 (en) | 2022-04-05 | 2025-02-25 | Thermo Finnigan Llc | Ion mobility enhanced qualitative and quantitative methods |
| WO2024194832A1 (en) * | 2023-03-23 | 2024-09-26 | Dh Technologies Development Pte. Ltd. | Method and system for introducing modifier into a curtain gas stream for a differential mobility spectrometer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432343A (en) * | 1993-06-03 | 1995-07-11 | Gulcicek; Erol E. | Ion focusing lensing system for a mass spectrometer interfaced to an atmospheric pressure ion source |
| US7164122B2 (en) * | 2000-02-29 | 2007-01-16 | Ionwerks, Inc. | Ion mobility spectrometer |
| WO2001069218A2 (en) * | 2000-03-14 | 2001-09-20 | National Research Council Canada | Tandem faims/ion-trapping apparatus and method |
| JP4802104B2 (ja) * | 2003-11-25 | 2011-10-26 | サイオネックス コーポレイション | サンプルの分析を改善するための分散特性、サンプル解離及び／又は圧力制御を用いた移動度ベースの装置及び方法 |
| GB0503010D0 (en) | 2005-02-14 | 2005-03-16 | Micromass Ltd | Mass spectrometer |
| EP1982349B1 (en) * | 2006-02-07 | 2018-07-25 | DH Technologies Development Pte. Ltd. | Chemical noise reduction for mass spectrometry |
| US7812305B2 (en) * | 2006-06-29 | 2010-10-12 | Sionex Corporation | Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis |
| US7598488B2 (en) * | 2006-09-20 | 2009-10-06 | Park Melvin A | Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry |
| US7863562B2 (en) * | 2007-06-22 | 2011-01-04 | Shimadzu Corporation | Method and apparatus for digital differential ion mobility separation |
| EP2281297B1 (en) * | 2008-05-30 | 2019-01-16 | DH Technologies Development Pte. Ltd. | Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity |
-
2011
- 2011-01-28 JP JP2012551316A patent/JP5985989B2/ja not_active Expired - Fee Related
- 2011-01-28 CA CA2788455A patent/CA2788455C/en not_active Expired - Fee Related
- 2011-01-28 EP EP11704506.2A patent/EP2529387B1/en not_active Not-in-force
- 2011-01-28 US US13/016,257 patent/US20110183431A1/en not_active Abandoned
- 2011-01-28 WO PCT/US2011/022905 patent/WO2011094529A2/en not_active Ceased
-
2012
- 2012-12-04 US US13/693,837 patent/US9305762B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2788455A1 (en) | 2011-08-04 |
| US9305762B2 (en) | 2016-04-05 |
| EP2529387B1 (en) | 2018-08-01 |
| WO2011094529A2 (en) | 2011-08-04 |
| EP2529387A2 (en) | 2012-12-05 |
| JP5985989B2 (ja) | 2016-09-06 |
| US20110183431A1 (en) | 2011-07-28 |
| US20130092834A1 (en) | 2013-04-18 |
| WO2011094529A3 (en) | 2011-10-06 |
| JP2013518396A (ja) | 2013-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160121 |
|
| MKLA | Lapsed |
Effective date: 20210831 |
|
| MKLA | Lapsed |
Effective date: 20200128 |