CA2786777A1 - Obesity small molecules - Google Patents

Info

Publication number

CA2786777A1

CA2786777A1 CA2786777A CA2786777A CA2786777A1 CA 2786777 A1 CA2786777 A1 CA 2786777A1 CA 2786777 A CA2786777 A CA 2786777A CA 2786777 A CA2786777 A CA 2786777A CA 2786777 A1 CA2786777 A1 CA 2786777A1

Authority

CA

Canada

Prior art keywords

cyp3a4

compound

abcb1

jun

mice

Prior art date

2010-01-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 235000020824 obesity Nutrition 0.000 title claims abstract description 33
• 150000003384 small molecules Chemical class 0.000 title description 4
• 230000001603 reducing effect Effects 0.000 claims abstract description 14
• 230000037396 body weight Effects 0.000 claims abstract description 6
• 238000002560 therapeutic procedure Methods 0.000 claims abstract description 6
• 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims description 191
• -1 S-17092 Chemical compound 0.000 claims description 103
• 150000001875 compounds Chemical class 0.000 claims description 85
• 108090000623 proteins and genes Proteins 0.000 claims description 58
• 238000011282 treatment Methods 0.000 claims description 33
• 230000001225 therapeutic effect Effects 0.000 claims description 26
• 239000003814 drug Substances 0.000 claims description 20
• 238000000034 method Methods 0.000 claims description 20
• 210000000577 adipose tissue Anatomy 0.000 claims description 16
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• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 12
• 239000005511 L01XE05 - Sorafenib Substances 0.000 claims description 12
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• 229960003787 sorafenib Drugs 0.000 claims description 12
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• UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims description 11
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