CA2782429A1 - Assay method and apparatus - Google Patents
Assay method and apparatus Download PDFInfo
- Publication number
- CA2782429A1 CA2782429A1 CA2782429A CA2782429A CA2782429A1 CA 2782429 A1 CA2782429 A1 CA 2782429A1 CA 2782429 A CA2782429 A CA 2782429A CA 2782429 A CA2782429 A CA 2782429A CA 2782429 A1 CA2782429 A1 CA 2782429A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- membrane
- driver
- receptor
- diffusion cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003556 assay Methods 0.000 title claims description 9
- 239000012530 fluid Substances 0.000 claims abstract description 57
- 238000009792 diffusion process Methods 0.000 claims abstract description 46
- 239000012528 membrane Substances 0.000 claims description 102
- 230000033001 locomotion Effects 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 26
- 230000008859 change Effects 0.000 claims description 14
- 125000004122 cyclic group Chemical group 0.000 claims description 12
- 238000006073 displacement reaction Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 230000000737 periodic effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 19
- 238000003825 pressing Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 52
- 210000004027 cell Anatomy 0.000 description 37
- 238000005070 sampling Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 14
- 230000008901 benefit Effects 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000002105 nanoparticle Substances 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 238000001727 in vivo Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 230000037384 skin absorption Effects 0.000 description 5
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- 239000002537 cosmetic Substances 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000008366 buffered solution Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000010874 in vitro model Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 230000003534 oscillatory effect Effects 0.000 description 2
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- 230000002572 peristaltic effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 231100000233 OECD 428 Skin Absorption: In Vitro Method Toxicity 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000036557 dermal exposure Effects 0.000 description 1
- 231100000823 dermal exposure Toxicity 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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- 210000001723 extracellular space Anatomy 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 238000013334 tissue model Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032895 transmembrane transport Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
- G01N3/10—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
- G01N3/12—Pressure testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/32—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
- G01N3/36—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by pneumatic or hydraulic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/006—Dissolution of tablets or the like
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0016—Tensile or compressive
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/003—Generation of the force
- G01N2203/005—Electromagnetic means
- G01N2203/0051—Piezoelectric means
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0921048.5A GB0921048D0 (en) | 2009-12-01 | 2009-12-01 | Assay method and apparatus |
| GB0921048.5 | 2009-12-01 | ||
| PCT/GB2010/051992 WO2011067587A1 (en) | 2009-12-01 | 2010-11-30 | Assay method and apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2782429A1 true CA2782429A1 (en) | 2011-06-09 |
Family
ID=41572991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2782429A Abandoned CA2782429A1 (en) | 2009-12-01 | 2010-11-30 | Assay method and apparatus |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120324984A1 (enExample) |
| EP (1) | EP2507611A1 (enExample) |
| JP (1) | JP2013512448A (enExample) |
| AU (1) | AU2010326377A1 (enExample) |
| CA (1) | CA2782429A1 (enExample) |
| GB (1) | GB0921048D0 (enExample) |
| WO (1) | WO2011067587A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150233809A1 (en) * | 2012-08-14 | 2015-08-20 | Fondazione Istituto Italiano Di Tecnologia | Device and method for determining the dissolution kinetics of colloidal nanoparticles |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10191037B2 (en) | 2012-11-09 | 2019-01-29 | Aushon Biosystems, Inc. | Methods of and systems for improved detection sensitivity of assays |
| CN103499519A (zh) * | 2013-10-10 | 2014-01-08 | 河南科技大学 | 一种复合物理场经皮给药实验装置 |
| JP6393329B2 (ja) | 2013-11-29 | 2018-09-19 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 頭皮強化および／またはフケ防止の能力を明らかにする方法 |
| JP6367011B2 (ja) * | 2014-06-04 | 2018-08-01 | 国立研究開発法人産業技術総合研究所 | Ｓｖｏｃ類経皮曝露量測定装置 |
| US10473574B2 (en) * | 2014-11-17 | 2019-11-12 | Syddansk Universitet | Assembly for assessing drug permeability with adjustable biomimetic properties |
| JP6639160B2 (ja) * | 2015-09-02 | 2020-02-05 | 株式会社川本製作所 | 試験方法 |
| US10705004B2 (en) * | 2015-10-01 | 2020-07-07 | Galderma Research & Development | Diffusion cell and uses for evaluating the diffusion of a compound through a membrane |
| EP3228239B1 (de) * | 2016-04-06 | 2019-02-06 | Courage + Khazaka electronic GmbH | Vorrichtung und verfahren zur messung einer durch diffusion durch mindestens ein probenmaterial abgegebenen menge eines stoffes für ein messzellensystem |
| FR3054144B1 (fr) * | 2016-07-20 | 2021-01-01 | Inst De Radioprotection Et De Surete Nucleaire | Dispositif de gradient de diffusion en couche mince et appareil de mise au point d’un tel dispositif |
| WO2021053877A1 (ja) * | 2019-09-18 | 2021-03-25 | 富士フイルム株式会社 | 多孔膜の透過性の評価方法、細胞の評価方法及び薬剤の評価方法 |
| DE102020101584B4 (de) * | 2020-01-23 | 2024-10-02 | Lts Lohmann Therapie-Systeme Ag | Modifizierte Franz-Zelle |
| CN112945801B (zh) * | 2021-02-01 | 2024-02-09 | 南京海关工业产品检测中心 | 一种用于模拟漱口过程的透皮扩散池及透皮扩散实验仪 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2303597A (en) * | 1940-05-09 | 1942-12-01 | Infilco Inc | Measuring pump |
| US4578244A (en) * | 1982-04-23 | 1986-03-25 | Pharmacontrol Corp. | Sampling apparatus for obtaining a plurality of fluid samples |
| CA1291948C (en) * | 1986-04-24 | 1991-11-12 | Albert E. Chu | Variable volume assay device and method |
| US4740309A (en) * | 1986-08-29 | 1988-04-26 | Iprx, Inc. | Methods and apparatus for determining the rate of movement of a study substance through a membrane |
| US5547351A (en) * | 1994-03-01 | 1996-08-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Low pressure low volume liquid pump |
| US6022733A (en) * | 1997-12-02 | 2000-02-08 | Tam; Yun K. | Simulated biological dissolution and absorption system |
| FR2845771A1 (fr) * | 2002-10-09 | 2004-04-16 | Ncv Ind | Appareil de caracterisation de materiaux et procede associe |
| EP1608950A1 (en) * | 2003-03-28 | 2005-12-28 | Alza Corporation | Static diffusion cell for diffusion sampling systems |
| EP1777510A1 (en) * | 2005-10-21 | 2007-04-25 | Rohm and Haas Company | Dissolution test equipment and methods for testing |
| DE112007003302T5 (de) * | 2007-01-31 | 2009-12-03 | Cosmed Pharmaceutical Co., Ltd. | Gerät zur Messung der Diffusion einer transdermalen Absorptionszubereitung |
| US20090064768A1 (en) * | 2007-03-13 | 2009-03-12 | Emad Alkhawam | Devices for Determining the Release Profile of Macromolecules and Methods of Using the Same |
-
2009
- 2009-12-01 GB GBGB0921048.5A patent/GB0921048D0/en not_active Ceased
-
2010
- 2010-11-30 WO PCT/GB2010/051992 patent/WO2011067587A1/en not_active Ceased
- 2010-11-30 JP JP2012541577A patent/JP2013512448A/ja active Pending
- 2010-11-30 EP EP10787541A patent/EP2507611A1/en not_active Withdrawn
- 2010-11-30 US US13/513,339 patent/US20120324984A1/en not_active Abandoned
- 2010-11-30 CA CA2782429A patent/CA2782429A1/en not_active Abandoned
- 2010-11-30 AU AU2010326377A patent/AU2010326377A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150233809A1 (en) * | 2012-08-14 | 2015-08-20 | Fondazione Istituto Italiano Di Tecnologia | Device and method for determining the dissolution kinetics of colloidal nanoparticles |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013512448A (ja) | 2013-04-11 |
| WO2011067587A1 (en) | 2011-06-09 |
| US20120324984A1 (en) | 2012-12-27 |
| EP2507611A1 (en) | 2012-10-10 |
| GB0921048D0 (en) | 2010-01-13 |
| AU2010326377A1 (en) | 2012-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20151201 |