CA2781313C - Enhanced eductor design - Google Patents

Enhanced eductor design Download PDF

Info

Publication number
CA2781313C
CA2781313C CA2781313A CA2781313A CA2781313C CA 2781313 C CA2781313 C CA 2781313C CA 2781313 A CA2781313 A CA 2781313A CA 2781313 A CA2781313 A CA 2781313A CA 2781313 C CA2781313 C CA 2781313C
Authority
CA
Canada
Prior art keywords
eductor
modification member
constriction zone
siphon
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2781313A
Other languages
English (en)
French (fr)
Other versions
CA2781313A1 (en
Inventor
Benjamin Stedman
Prashant Kakade
Darrell Woehler
John Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAP Pharmaceuticals Inc
Original Assignee
MAP Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAP Pharmaceuticals Inc filed Critical MAP Pharmaceuticals Inc
Publication of CA2781313A1 publication Critical patent/CA2781313A1/en
Application granted granted Critical
Publication of CA2781313C publication Critical patent/CA2781313C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/312—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof
    • B01F25/3124—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow
    • B01F25/31242—Injector mixers in conduits or tubes through which the main component flows with Venturi elements; Details thereof characterised by the place of introduction of the main flow the main flow being injected in the central area of the venturi, creating an aspiration in the circumferential part of the conduit
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
    • F04F5/00—Jet pumps, i.e. devices in which flow is induced by pressure drop caused by velocity of another fluid flow
    • F04F5/44—Component parts, details, or accessories not provided for in, or of interest apart from, groups F04F5/02 - F04F5/42
    • F04F5/46—Arrangements of nozzles
    • F04F5/463—Arrangements of nozzles with provisions for mixing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00—Influencing flow of fluids
    • F15D1/02—Influencing flow of fluids in pipes or conduits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Jet Pumps And Other Pumps (AREA)
CA2781313A 2009-12-23 2010-12-23 Enhanced eductor design Active CA2781313C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28478409P 2009-12-23 2009-12-23
US61/284,784 2009-12-23
PCT/US2010/062084 WO2011079310A1 (en) 2009-12-23 2010-12-23 Enhanced eductor design

Publications (2)

Publication Number Publication Date
CA2781313A1 CA2781313A1 (en) 2011-06-30
CA2781313C true CA2781313C (en) 2019-09-17

Family

ID=44185936

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2781313A Active CA2781313C (en) 2009-12-23 2010-12-23 Enhanced eductor design

Country Status (9)

Country Link
US (4) US9227030B2 (https=)
EP (1) EP2515978B1 (https=)
JP (3) JP5781540B2 (https=)
CN (1) CN102686261B (https=)
AU (1) AU2010336338B2 (https=)
CA (1) CA2781313C (https=)
IL (3) IL219744A (https=)
IN (1) IN2012DN04857A (https=)
WO (1) WO2011079310A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
RU2009105642A (ru) * 2006-08-22 2010-09-27 Глаксо Груп Лимитед (GB) Средство приведения в действие для ингалятора
EP2066383A1 (en) * 2006-08-22 2009-06-10 Glaxo Group Limited Actuator for an inhaler
US8875697B2 (en) * 2007-07-24 2014-11-04 Ric Investments, Llc Drug delivery apparatus and method
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN101827626B (zh) 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2010280531B2 (en) * 2009-08-07 2015-11-26 Kind Consumer Limited An inhaler
IN2012DN04857A (https=) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc
CN102985125A (zh) * 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
MX2015002027A (es) 2012-08-29 2015-06-05 Chiesi Farma Spa Dispositivo de inhalacion de aerosol.
WO2014140724A1 (en) * 2013-03-14 2014-09-18 Trudell Medical International Metered dose inhaler applicator
EP2993997B1 (en) * 2013-05-10 2023-08-02 Fontem Ventures B.V. Flavor vortex device
GB201308679D0 (en) 2013-05-14 2013-06-26 3M Innovative Properties Co Actuator for an inhaler
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN103877655B (zh) * 2014-04-08 2015-12-30 隋宁昕 自吸固定式吸氧鼻塞
US11291780B2 (en) * 2014-12-04 2022-04-05 Vyaire Medical Consumables Llc Breath-actuated nebulizer for medicine inhalation
CN113616885B (zh) * 2015-12-21 2024-06-21 3M创新有限公司 药用吸入器
GB201702407D0 (en) 2017-02-14 2017-03-29 Norton (Waterford) Ltd Inhalers and related methods
GB201707095D0 (en) * 2017-05-04 2017-06-21 3M Innovative Properties Co Inhaler flow control mechanism
CN109210374B (zh) * 2017-06-30 2021-06-08 北京北方华创微电子装备有限公司 进气管路及半导体加工设备
CA3095939C (en) * 2018-04-06 2023-09-26 Frank Levy Apparatus and method for producing an enriched medical suspension
CN110433366B (zh) * 2019-08-12 2022-03-04 杭州市红十字会医院 一种便携式呼吸科给药器
CN113898570B (zh) * 2021-12-08 2022-02-08 常州萨柏美格医用气体设备有限公司 气体流动过程检测装置及方法、空气压缩机组及检测方法
CN114798201B (zh) * 2022-06-29 2022-10-04 山东沃德净水科技有限公司 一种喷射器优化方法及喷射器
WO2025030129A2 (en) * 2023-08-03 2025-02-06 United Industries Corporation Aerosol spray device, insecticide composition, and method of use
US12268807B1 (en) 2023-12-20 2025-04-08 Yale University Devices, systems, and methods for providing individualized delivery of suspended medication

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2037940A (en) * 1932-09-10 1936-04-21 Edward A Stalker Means for preventing the separation of the flow from curved surfaces
US3665949A (en) 1969-06-27 1972-05-30 Bendix Corp Gaseous controlled fluidic throttling valve
YU41046B (en) * 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US4044763A (en) * 1975-07-07 1977-08-30 Bird F M Ventilator and method
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
FR2645026B1 (fr) * 1989-03-31 1997-11-21 Boussignac Georges Dispositif d'assistance respiratoire
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
JP3194956B2 (ja) 1992-09-11 2001-08-06 グラクソ、グループ、リミテッド 吸入装置
US5727546A (en) * 1993-08-18 1998-03-17 Fisons Plc Powder inhaler with breath flow regulation valve
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
CZ289029B6 (cs) * 1994-09-21 2001-10-17 Inhale Therapeutic Systems Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
JP3530004B2 (ja) * 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
ATE390944T1 (de) * 1999-07-23 2008-04-15 Mannkind Corp Einzelportionskapseln für einen trockenpulverinhalator
US6367471B1 (en) 1999-11-01 2002-04-09 Sheffield Pharmaceuticals, Inc. Internal vortex mechanism for inhaler device
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
DE10024738A1 (de) 2000-05-19 2001-11-29 Qvf Engineering Gmbh Glasbauteile mit einer ableitfähigen Beschichtung, ihre Verwendung und daraus hergestellte Apparate, Anlagen und Rohrleitungen
GB0016478D0 (en) 2000-07-05 2000-08-23 Innovata Biomed Ltd Valve
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
FI20002363A0 (fi) * 2000-10-27 2000-10-27 Orion Yhtymae Oyj Jauheinhalaattori
GB0222295D0 (en) * 2002-09-25 2002-10-30 3M Innovative Properties Co Breath actuated medicament dispensing devices
DE102005010965B3 (de) * 2005-03-10 2006-08-03 Medspray Xmems Bv Inhalator mit einem Mischkanal zum Erzeugen eines zu inhalierenden Aerosols
DE102006014433A1 (de) * 2006-03-27 2007-10-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen
RU2432190C2 (ru) * 2006-03-30 2011-10-27 Кэафьюжн 2200, Инк. Ингалятор со струйным контролем на основе скорости входа и относящиеся к нему способы применения
EP3034119B1 (en) * 2006-03-30 2018-03-21 Vyaire Medical Consumables LLC Nebulizer with pressure-based fluidic-control
MX2009009061A (es) * 2007-02-28 2009-11-12 Abbott Respiratory Llc Sistema de atomizacion a base de boquilla.
JP5462152B2 (ja) * 2008-04-17 2014-04-02 帝人ファーマ株式会社 定量噴霧式吸入器用吸入補助器具
CN101827626B (zh) * 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
IN2012DN04857A (https=) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc

Also Published As

Publication number Publication date
IL219744A (en) 2015-11-30
EP2515978B1 (en) 2018-02-14
AU2010336338B2 (en) 2015-02-19
IL242205A0 (en) 2015-11-30
EP2515978A1 (en) 2012-10-31
EP2515978A4 (en) 2015-03-04
JP5781540B2 (ja) 2015-09-24
US20200030555A1 (en) 2020-01-30
US20110155129A1 (en) 2011-06-30
AU2010336338A1 (en) 2012-06-21
IL252847A0 (en) 2017-08-31
WO2011079310A1 (en) 2011-06-30
IL252847B (en) 2021-02-28
US20160129208A1 (en) 2016-05-12
CN102686261B (zh) 2014-09-10
IL219744A0 (en) 2012-07-31
JP2013515577A (ja) 2013-05-09
CN102686261A (zh) 2012-09-19
JP6157542B2 (ja) 2017-07-05
US9227030B2 (en) 2016-01-05
JP2015221225A (ja) 2015-12-10
IN2012DN04857A (https=) 2015-09-25
US20170056609A1 (en) 2017-03-02
IL242205A (en) 2017-07-31
JP2017164554A (ja) 2017-09-21
CA2781313A1 (en) 2011-06-30
US9610415B2 (en) 2017-04-04

Similar Documents

Publication Publication Date Title
CA2781313C (en) Enhanced eductor design
JP5352630B2 (ja) エアロゾル流制御装置
CA2883143C (en) A breath operated inhaler with plume impiging air jets
US6983748B2 (en) Dry powder inhaler
HK1172857B (en) Enhanced eductor design
HK1172857A (en) Enhanced eductor design
HK1211186B (en) A breath operated inhaler with plume impiging air jets

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151211

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251020

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20260202

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260203

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260226