CA2779067C - Biodegradable implantable medical devices formed from super - pure magnesium-based material - Google Patents
Biodegradable implantable medical devices formed from super - pure magnesium-based material Download PDFInfo
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- CA2779067C CA2779067C CA2779067A CA2779067A CA2779067C CA 2779067 C CA2779067 C CA 2779067C CA 2779067 A CA2779067 A CA 2779067A CA 2779067 A CA2779067 A CA 2779067A CA 2779067 C CA2779067 C CA 2779067C
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- Prior art keywords
- super
- pure
- magnesium
- alloy
- endoprosthesis body
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- 239000011777 magnesium Substances 0.000 title claims abstract description 142
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 137
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 136
- 239000000463 material Substances 0.000 title claims abstract description 99
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 75
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 67
- 239000012535 impurity Substances 0.000 claims description 50
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- 239000010949 copper Substances 0.000 claims description 34
- 229910052759 nickel Inorganic materials 0.000 claims description 34
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 33
- 229910052738 indium Inorganic materials 0.000 claims description 33
- 229910017052 cobalt Inorganic materials 0.000 claims description 29
- 239000010941 cobalt Substances 0.000 claims description 29
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 29
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- 238000000034 method Methods 0.000 claims description 21
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- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
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- 229910052693 Europium Inorganic materials 0.000 description 1
- 229910017061 Fe Co Inorganic materials 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25649609P | 2009-10-30 | 2009-10-30 | |
| US61/256,496 | 2009-10-30 | ||
| EP09174604 | 2009-10-30 | ||
| EP09174604.0 | 2009-10-30 | ||
| PCT/EP2010/066431 WO2011051424A1 (en) | 2009-10-30 | 2010-10-29 | Biodegradable implantable medical devices formed from super - pure magnesium-based material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2779067A1 CA2779067A1 (en) | 2011-05-05 |
| CA2779067C true CA2779067C (en) | 2016-05-03 |
Family
ID=42357414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2779067A Expired - Fee Related CA2779067C (en) | 2009-10-30 | 2010-10-29 | Biodegradable implantable medical devices formed from super - pure magnesium-based material |
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| Country | Link |
|---|---|
| US (1) | US20120215301A1 (enExample) |
| EP (1) | EP2493523B1 (enExample) |
| JP (1) | JP5830467B2 (enExample) |
| CN (1) | CN102802689B (enExample) |
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| BR (1) | BR112012009953B1 (enExample) |
| CA (1) | CA2779067C (enExample) |
| DK (1) | DK2493523T3 (enExample) |
| EA (1) | EA029095B1 (enExample) |
| ES (1) | ES2487631T3 (enExample) |
| IL (1) | IL219395A (enExample) |
| MX (1) | MX2012004555A (enExample) |
| NZ (1) | NZ599548A (enExample) |
| PL (1) | PL2493523T3 (enExample) |
| PT (1) | PT2493523E (enExample) |
| TW (1) | TWI517865B (enExample) |
| WO (1) | WO2011051424A1 (enExample) |
| ZA (1) | ZA201202911B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2423354T3 (es) * | 2011-02-01 | 2013-09-19 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Aleación de magnesio que contiene metales de tierras raras |
| US20130090741A1 (en) * | 2011-10-07 | 2013-04-11 | Medtronic Vascular, Inc. | Magnesium Alloys for Bioabsorbable Stent |
| EP2630978B1 (de) | 2012-02-22 | 2018-10-31 | Biotronik AG | Implantat und verfahren zur herstellung desselben |
| EP2656944B1 (de) | 2012-04-23 | 2018-03-21 | Biotronik AG | Verfahren zur Herstellung eines Implantats |
| SG11201406023RA (en) | 2012-06-26 | 2014-10-30 | Biotronik Ag | Magnesium alloy, method for production thereof, and use thereof |
| SG11201406026TA (en) * | 2012-06-26 | 2014-10-30 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| KR102246887B1 (ko) * | 2012-06-26 | 2021-05-03 | 바이오트로닉 아게 | 마그네슘-알루미늄-아연 합금, 이의 제조방법 및 이의 용도 |
| HK1200881A1 (en) * | 2012-06-26 | 2015-08-14 | 百多力股份公司 | Magnesium alloy, method for the production thereof and use thereof |
| JP6392250B2 (ja) * | 2013-02-15 | 2018-09-19 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 生体内分解性の内部人工器官およびそれに使用する生体内分解性マグネシウム合金を加工する方法 |
| CN104109786B (zh) * | 2013-04-22 | 2016-10-05 | 比亚迪股份有限公司 | 一种镁合金及其制备方法 |
| EP3050996A4 (en) * | 2013-09-24 | 2017-10-04 | Olympus Corporation | Implant and manufacturing method therefor |
| WO2015066181A1 (en) | 2013-10-29 | 2015-05-07 | Boston Scientific Scimed, Inc. | Bioerodible magnesium alloy microstructures for endoprostheses |
| JP2015119893A (ja) * | 2013-12-25 | 2015-07-02 | 堤総研株式会社 | 生体器具 |
| US10327890B2 (en) * | 2014-01-22 | 2019-06-25 | Biotronik Ag | Thermochemically treated miniature tubes as semifinished products for vascular stents |
| WO2015171585A1 (en) | 2014-05-05 | 2015-11-12 | The University Of Toledo | Biodegradable magnesium alloys and composites |
| KR101722310B1 (ko) * | 2015-02-17 | 2017-03-31 | 서울대학교산학협력단 | 생체 분해성 마그네슘 및 생체 분해성 마그네슘의 분해속도 제어방법 |
| CN107427603A (zh) | 2015-03-11 | 2017-12-01 | 波士顿科学国际有限公司 | 用于内假体的生物溶蚀性镁合金微结构 |
| KR101933589B1 (ko) | 2015-12-28 | 2018-12-31 | 한국기계연구원 | 기계적 특성 및 내식성이 우수한 마그네슘 합금 및 이의 제조방법 |
| KR101976074B1 (ko) * | 2017-07-10 | 2019-05-08 | 주식회사 엠아이텍 | 생분해성 스텐트 제조 방법 |
| CN110541098A (zh) * | 2019-10-22 | 2019-12-06 | 中南大学 | 一种耐腐蚀生物镁铟合金及其制备方法和应用 |
| WO2021119391A1 (en) * | 2019-12-12 | 2021-06-17 | Edwards Lifesciences Corporation | Hybrid annuloplasty ring |
| CN111571128B (zh) * | 2020-05-07 | 2022-07-05 | 沪创医疗科技（上海）有限公司 | 生物可降解超细晶镁合金血管内支架的制备方法 |
| CN111922648B (zh) * | 2020-08-14 | 2021-06-29 | 北京理工大学 | 一种可降解镁合金心血管支架的精雕加工方法 |
| EP4260882A4 (en) * | 2020-12-14 | 2024-10-16 | Nitto Seiko Co., Ltd. | Biodegradable medical implement |
| CN113017733A (zh) * | 2021-03-30 | 2021-06-25 | 苏州奥芮济医疗科技有限公司 | 一种医疗锚钉及其加工工艺 |
| JP2023124565A (ja) * | 2022-02-25 | 2023-09-06 | 日東精工株式会社 | 生分解性医療器具 |
| WO2025023199A1 (ja) * | 2023-07-24 | 2025-01-30 | 日東精工株式会社 | マグネシウムワイヤ、マグネシウムワイヤの製造方法、および、マグネシウムワイヤの評価方法 |
| CN118835122B (zh) * | 2024-09-14 | 2025-08-08 | 广州众山轻合金有限公司 | 一种用于医疗器械的半固态合金材料及其制备方法 |
| CN119819946B (zh) * | 2025-03-17 | 2025-06-17 | 吉林大学 | 一种激光粉末床熔化制备可降解镁合金血管支架的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5582630A (en) * | 1995-02-21 | 1996-12-10 | Sony Corporation | Ultra high purity magnesium vacuum distillation purification method |
| DE19731021A1 (de) | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo abbaubares metallisches Implantat |
| DE59913189D1 (de) | 1998-06-25 | 2006-05-04 | Biotronik Ag | Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent |
| DE10128100A1 (de) | 2001-06-11 | 2002-12-19 | Hannover Med Hochschule | Medizinisches Implantat für den menschlichen und tierischen Körper |
| JP3857589B2 (ja) * | 2002-01-28 | 2006-12-13 | 同和鉱業株式会社 | 高純度金属の精製方法及び精製装置 |
| DE10253634A1 (de) | 2002-11-13 | 2004-05-27 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endoprothese |
| EP1835042A1 (en) | 2006-03-18 | 2007-09-19 | Acrostak Corp. | Magnesium-based alloy with improved combination of mechanical and corrosion characteristics |
| JPWO2007108450A1 (ja) * | 2006-03-20 | 2009-08-06 | 独立行政法人物質・材料研究機構 | 医療用生分解性デバイスの分解時間制御方法 |
| AU2007245256A1 (en) * | 2006-04-28 | 2007-11-08 | Biomagnesium Systems Ltd. | Biodegradable magnesium alloys and uses thereof |
| DK2000551T3 (da) | 2007-05-28 | 2011-01-10 | Acrostak Corp Bvi | Magnesium-baserede legeringer |
| DE102007043883A1 (de) | 2007-09-14 | 2009-03-26 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung |
| DE102008002601A1 (de) | 2008-02-05 | 2009-08-06 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Eisenlegierung |
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2010
- 2010-10-29 BR BR112012009953A patent/BR112012009953B1/pt not_active IP Right Cessation
- 2010-10-29 PL PL10779734T patent/PL2493523T3/pl unknown
- 2010-10-29 NZ NZ599548A patent/NZ599548A/xx not_active IP Right Cessation
- 2010-10-29 CN CN201080060323.XA patent/CN102802689B/zh not_active Expired - Fee Related
- 2010-10-29 DK DK10779734.2T patent/DK2493523T3/da active
- 2010-10-29 MX MX2012004555A patent/MX2012004555A/es active IP Right Grant
- 2010-10-29 US US13/505,220 patent/US20120215301A1/en not_active Abandoned
- 2010-10-29 PT PT107797342T patent/PT2493523E/pt unknown
- 2010-10-29 TW TW099137316A patent/TWI517865B/zh not_active IP Right Cessation
- 2010-10-29 ES ES10779734.2T patent/ES2487631T3/es active Active
- 2010-10-29 EP EP10779734.2A patent/EP2493523B1/en not_active Revoked
- 2010-10-29 AU AU2010311439A patent/AU2010311439B2/en not_active Ceased
- 2010-10-29 JP JP2012535841A patent/JP5830467B2/ja not_active Expired - Fee Related
- 2010-10-29 CA CA2779067A patent/CA2779067C/en not_active Expired - Fee Related
- 2010-10-29 EA EA201200685A patent/EA029095B1/ru not_active IP Right Cessation
- 2010-10-29 WO PCT/EP2010/066431 patent/WO2011051424A1/en not_active Ceased
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2012
- 2012-04-20 ZA ZA2012/02911A patent/ZA201202911B/en unknown
- 2012-04-24 IL IL219395A patent/IL219395A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT2493523E (pt) | 2014-08-05 |
| AU2010311439B2 (en) | 2013-06-20 |
| TWI517865B (zh) | 2016-01-21 |
| IL219395A0 (en) | 2012-06-28 |
| ZA201202911B (en) | 2013-06-26 |
| MX2012004555A (es) | 2012-08-03 |
| EA201200685A1 (ru) | 2012-11-30 |
| TW201130525A (en) | 2011-09-16 |
| IL219395A (en) | 2016-09-29 |
| HK1175126A1 (en) | 2013-06-28 |
| EP2493523B1 (en) | 2014-06-18 |
| NZ599548A (en) | 2013-04-26 |
| BR112012009953A2 (pt) | 2016-03-08 |
| CN102802689A (zh) | 2012-11-28 |
| DK2493523T3 (da) | 2014-09-01 |
| JP2013509217A (ja) | 2013-03-14 |
| BR112012009953B1 (pt) | 2018-08-28 |
| CA2779067A1 (en) | 2011-05-05 |
| PL2493523T3 (pl) | 2014-11-28 |
| EA029095B1 (ru) | 2018-02-28 |
| WO2011051424A1 (en) | 2011-05-05 |
| EP2493523A1 (en) | 2012-09-05 |
| ES2487631T3 (es) | 2014-08-22 |
| US20120215301A1 (en) | 2012-08-23 |
| CN102802689B (zh) | 2014-12-17 |
| AU2010311439A1 (en) | 2012-05-17 |
| JP5830467B2 (ja) | 2015-12-09 |
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| EEER | Examination request |
Effective date: 20131120 |
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| MKLA | Lapsed |
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