CA2777068C - Antibodies to epha3 - Google Patents
Antibodies to epha3 Download PDFInfo
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- CA2777068C CA2777068C CA2777068A CA2777068A CA2777068C CA 2777068 C CA2777068 C CA 2777068C CA 2777068 A CA2777068 A CA 2777068A CA 2777068 A CA2777068 A CA 2777068A CA 2777068 C CA2777068 C CA 2777068C
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25166809P | 2009-10-14 | 2009-10-14 | |
| US61/251,668 | 2009-10-14 | ||
| PCT/US2010/052725 WO2011053465A1 (en) | 2009-10-14 | 2010-10-14 | Antibodies to epha3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2777068A1 CA2777068A1 (en) | 2011-05-05 |
| CA2777068C true CA2777068C (en) | 2020-05-26 |
Family
ID=43499991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2777068A Active CA2777068C (en) | 2009-10-14 | 2010-10-14 | Antibodies to epha3 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8664365B2 (OSRAM) |
| EP (1) | EP2488554B1 (OSRAM) |
| JP (2) | JP2013508292A (OSRAM) |
| CN (1) | CN102666589B (OSRAM) |
| AU (1) | AU2010313621C1 (OSRAM) |
| CA (1) | CA2777068C (OSRAM) |
| DK (1) | DK2488554T3 (OSRAM) |
| ES (1) | ES2743558T3 (OSRAM) |
| PL (1) | PL2488554T3 (OSRAM) |
| PT (1) | PT2488554T (OSRAM) |
| WO (1) | WO2011053465A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2558121A4 (en) * | 2010-04-01 | 2014-01-08 | Kalobios Pharmaceuticals Inc | EPHA3 ANTIBODY FOR THE TREATMENT OF MULTIPLE MYELOMES |
| CA2802723A1 (en) * | 2010-06-18 | 2011-12-22 | Kalobios Pharmaceuticals, Inc. | Detection of epha3 as a marker of the presence of a solid tumor |
| CA2844674A1 (en) | 2011-08-12 | 2013-02-21 | Kalobios Pharmaceuticals, Inc. | Methods of treating hematological proliferative disorders by targeting epha3 expressed on aberrant vasculature in bone marrow |
| PH12019501393B1 (en) * | 2013-08-01 | 2022-09-07 | Five Prime Therapeutics Inc | Afucosylated anti-fgfr2iiib antibodies |
| CN108368174B (zh) | 2015-11-23 | 2023-04-14 | 戊瑞治疗有限公司 | 用于癌症治疗的单独fgfr2抑制剂或与免疫刺激剂的组合 |
| EP3512883A1 (en) * | 2016-09-13 | 2019-07-24 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
| BR112019023898A2 (pt) | 2017-05-16 | 2020-06-09 | Five Prime Therapeutics Inc | método para tratamento de câncer gástrico, uso de um anticorpo e composição |
| WO2019165982A1 (en) * | 2018-02-28 | 2019-09-06 | WuXi Biologics Ireland Limited | Monoclonal antibody against human lag-3, method for preparing same, and use thereof |
| CN114787190A (zh) * | 2019-10-09 | 2022-07-22 | 昆士兰医学研究所理事会 | 靶向epha3及其用途 |
| US12139544B2 (en) | 2019-11-08 | 2024-11-12 | Mayo Foundation For Medical Education And Research | EphA3 directed CAR-T cells for treatment of tumors |
| WO2022087484A1 (en) * | 2020-10-23 | 2022-04-28 | Williams Katherine L | Antibodies to coronavirus sars-cov-2 |
| JP7726496B2 (ja) * | 2021-08-06 | 2025-08-20 | コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー | 新規な抗ＥｐｈＡ２キメラ抗原受容体及びそれを発現する免疫細胞 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| ES2230537T3 (es) | 1991-06-21 | 2005-05-01 | The Walter And Eliza Hall Institute Of Medical Research | Una tirosina quinasa de tipo receptor (quinasa de tipo eph/elk hunaba-henki y uso de la misma. |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| NO175798C (no) | 1992-07-22 | 1994-12-07 | Sinvent As | Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| KR101155191B1 (ko) | 1999-01-15 | 2012-06-13 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| ES2568899T3 (es) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| DE60114830T2 (de) | 2000-06-28 | 2006-08-03 | Glycofi, Inc. | Verfahren zur herstellung modifizierter glycoproteine |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| DK1355919T3 (da) | 2000-12-12 | 2011-03-14 | Medimmune Llc | Molekyler med længere halveringstider, sammensætninger og anvendelser deraf |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2799805C (en) | 2002-03-19 | 2016-05-17 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| KR100980065B1 (ko) | 2002-09-27 | 2010-09-03 | 젠코어 인코포레이티드 | 최적화된 Ｆｃ 변이체 및 그의 제조 방법 |
| JP4782700B2 (ja) | 2004-01-20 | 2011-09-28 | カロバイオス ファーマシューティカルズ インコーポレイティッド | 最低限必須な結合決定基を用いた抗体特異性の移入 |
| EP1778726A4 (en) | 2004-08-16 | 2009-03-18 | Medimmune Inc | INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY |
| WO2006052409A2 (en) * | 2004-10-23 | 2006-05-18 | Case Western Reserve University | Peptide and small molecule agonists of epha and their uses |
| EP1824987B1 (en) | 2004-11-16 | 2013-08-21 | KaloBios Pharmaceuticals, Inc. | Immunoglobulin variable region cassette exchange |
| US8211648B2 (en) | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| WO2008060092A1 (en) | 2006-11-17 | 2008-05-22 | Sang Yun Park | Rotative force generator |
| AU2008226905C1 (en) | 2007-03-08 | 2014-11-06 | Humanigen, Inc. | EphA3 antibodies for the treatment of solid tumors |
| CL2008002782A1 (es) | 2007-09-21 | 2009-07-31 | Genentech Inc | Anticuerpo anti-bv8 neutralizante; composicion que lo comprende; y su uso para tratar tumores en humanos previamente tratados con un antagonista del factor de crecimiento endotelial vascular. |
| JP5876728B2 (ja) | 2009-03-06 | 2016-03-02 | カロバイオス ファーマシューティカルズ インコーポレイティッド | ＥｐｈＡ３に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
-
2010
- 2010-10-14 JP JP2012534368A patent/JP2013508292A/ja active Pending
- 2010-10-14 PT PT10777137T patent/PT2488554T/pt unknown
- 2010-10-14 WO PCT/US2010/052725 patent/WO2011053465A1/en not_active Ceased
- 2010-10-14 PL PL10777137T patent/PL2488554T3/pl unknown
- 2010-10-14 DK DK10777137.0T patent/DK2488554T3/da active
- 2010-10-14 CA CA2777068A patent/CA2777068C/en active Active
- 2010-10-14 EP EP10777137.0A patent/EP2488554B1/en active Active
- 2010-10-14 ES ES10777137T patent/ES2743558T3/es active Active
- 2010-10-14 AU AU2010313621A patent/AU2010313621C1/en active Active
- 2010-10-14 CN CN201080056618.XA patent/CN102666589B/zh active Active
- 2010-10-14 US US12/904,953 patent/US8664365B2/en active Active
-
2013
- 2013-12-30 US US14/143,427 patent/US9290571B2/en active Active
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2015
- 2015-11-25 JP JP2015229465A patent/JP2016094424A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2488554B1 (en) | 2019-07-24 |
| CA2777068A1 (en) | 2011-05-05 |
| DK2488554T3 (da) | 2019-09-02 |
| ES2743558T3 (es) | 2020-02-19 |
| CN102666589A (zh) | 2012-09-12 |
| PT2488554T (pt) | 2019-09-13 |
| US20140120114A1 (en) | 2014-05-01 |
| WO2011053465A1 (en) | 2011-05-05 |
| AU2010313621C1 (en) | 2015-11-26 |
| PL2488554T3 (pl) | 2020-03-31 |
| AU2010313621A1 (en) | 2012-05-03 |
| US8664365B2 (en) | 2014-03-04 |
| US9290571B2 (en) | 2016-03-22 |
| EP2488554A1 (en) | 2012-08-22 |
| AU2010313621B2 (en) | 2015-07-30 |
| JP2013508292A (ja) | 2013-03-07 |
| CN102666589B (zh) | 2014-08-20 |
| US20110123549A1 (en) | 2011-05-26 |
| JP2016094424A (ja) | 2016-05-26 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20151005 |