CA2772907C - Selective antibacterials for clostridium difficile infections - Google Patents
Selective antibacterials for clostridium difficile infections Download PDFInfo
- Publication number
- CA2772907C CA2772907C CA2772907A CA2772907A CA2772907C CA 2772907 C CA2772907 C CA 2772907C CA 2772907 A CA2772907 A CA 2772907A CA 2772907 A CA2772907 A CA 2772907A CA 2772907 C CA2772907 C CA 2772907C
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- CA
- Canada
- Prior art keywords
- oxopurine
- dichlorobenzylamino
- morpholinyl
- compound
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000844 anti-bacterial effect Effects 0.000 title description 3
- 208000037384 Clostridium Infections Diseases 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 115
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
- 241000193163 Clostridioides difficile Species 0.000 claims abstract description 24
- 201000010099 disease Diseases 0.000 claims abstract description 21
- -1 2-(N-morpholinyl)ethyl Chemical group 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
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Classifications
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27643609P | 2009-09-11 | 2009-09-11 | |
| US61/276,436 | 2009-09-11 | ||
| PCT/US2010/048379 WO2011031935A1 (en) | 2009-09-11 | 2010-09-10 | Selective antibacterials for clostridium difficile infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2772907A1 CA2772907A1 (en) | 2011-03-17 |
| CA2772907C true CA2772907C (en) | 2018-01-09 |
Family
ID=43732808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2772907A Active CA2772907C (en) | 2009-09-11 | 2010-09-10 | Selective antibacterials for clostridium difficile infections |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8796292B2 (enExample) |
| EP (1) | EP2475252B1 (enExample) |
| JP (1) | JP5934647B2 (enExample) |
| CA (1) | CA2772907C (enExample) |
| WO (1) | WO2011031935A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| US10723741B1 (en) * | 2018-12-21 | 2020-07-28 | Acurx Pharmaceuticals, Llc | DNA polymerase IIIC inhibitors and use thereof |
| JP2024522813A (ja) * | 2021-06-16 | 2024-06-21 | アクルクス ファーマシューティカルズ、インコーポレイテッド | マイクロバイオームの健康を促進するためのイベザポルスタットの使用 |
| CN120202009A (zh) * | 2022-10-17 | 2025-06-24 | 阿科利斯制药股份有限公司 | 用于改善健康的化合物和方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516905A (en) | 1994-08-30 | 1996-05-14 | University Of Massachusetts Medical Center | Antibiotic compounds and methods to treat gram-positive bacterial and mycoplasmal infections |
| DE19845153A1 (de) | 1998-10-01 | 2000-04-06 | Merck Patent Gmbh | Imidazo[4,5]-pyridin-4-on-derivate |
| AU2247701A (en) | 1999-10-21 | 2001-04-30 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
| WO2001028561A1 (en) | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
| WO2001029045A1 (en) | 1999-10-21 | 2001-04-26 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
| EP1401829B1 (en) | 2001-06-15 | 2012-08-22 | Microbiotix, Inc. | Novel heterocyclic antibacterial compounds |
| US6777420B2 (en) | 2001-06-15 | 2004-08-17 | Microbiotix, Inc. | Heterocyclic antibacterial compounds |
| CA2473724A1 (en) * | 2002-02-08 | 2003-08-14 | Glsynthesis Inc. | Purine and isosteric antibacterial compounds |
| AU2003240545A1 (en) * | 2002-06-06 | 2003-12-22 | Therapeutics Corporation Genome | Use of ramoplanin to treat diseases associated with the use of antibiotics |
| AU2003303953B2 (en) * | 2002-09-10 | 2007-10-04 | Microbiotix, Inc. | Antibacterial pyrazole carboxylic acid hydrazides |
| FR2906244B1 (fr) * | 2006-09-22 | 2010-09-10 | Centre Nat Rech Scient | Nouvelle classe de composes derives de terpene a activite antibiotique, compositions les contenant et utilisations. |
-
2010
- 2010-09-10 US US13/395,296 patent/US8796292B2/en active Active
- 2010-09-10 CA CA2772907A patent/CA2772907C/en active Active
- 2010-09-10 JP JP2012528919A patent/JP5934647B2/ja active Active
- 2010-09-10 WO PCT/US2010/048379 patent/WO2011031935A1/en not_active Ceased
- 2010-09-10 EP EP10816135.7A patent/EP2475252B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120232077A1 (en) | 2012-09-13 |
| EP2475252A4 (en) | 2013-07-10 |
| JP5934647B2 (ja) | 2016-06-15 |
| WO2011031935A1 (en) | 2011-03-17 |
| CA2772907A1 (en) | 2011-03-17 |
| JP2013504592A (ja) | 2013-02-07 |
| US8796292B2 (en) | 2014-08-05 |
| EP2475252B1 (en) | 2016-11-16 |
| EP2475252A1 (en) | 2012-07-18 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150902 |