CA2771900A1 - Tumoricidal, bactericidal, or viricidal macrophage activation - Google Patents

Tumoricidal, bactericidal, or viricidal macrophage activation Download PDF

Info

Publication number
CA2771900A1
CA2771900A1 CA2771900A CA2771900A CA2771900A1 CA 2771900 A1 CA2771900 A1 CA 2771900A1 CA 2771900 A CA2771900 A CA 2771900A CA 2771900 A CA2771900 A CA 2771900A CA 2771900 A1 CA2771900 A1 CA 2771900A1
Authority
CA
Canada
Prior art keywords
gcmaf
immobilized
nagalase
mammal
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2771900A
Other languages
English (en)
French (fr)
Inventor
Charles Knezevich
Robert Silvetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2771900A1 publication Critical patent/CA2771900A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687Chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2771900A 2009-08-22 2010-08-23 Tumoricidal, bactericidal, or viricidal macrophage activation Abandoned CA2771900A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23608809P 2009-08-22 2009-08-22
US61/236,088 2009-08-22
PCT/US2010/046356 WO2011028485A2 (en) 2009-08-22 2010-08-23 Tumoricidal, bactericidal, or viricidal macrophage activation

Publications (1)

Publication Number Publication Date
CA2771900A1 true CA2771900A1 (en) 2011-03-10

Family

ID=43649882

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2771900A Abandoned CA2771900A1 (en) 2009-08-22 2010-08-23 Tumoricidal, bactericidal, or viricidal macrophage activation

Country Status (8)

Country Link
US (1) US20110123591A1 (OSRAM)
EP (1) EP2467154A4 (OSRAM)
CN (1) CN102596223A (OSRAM)
AU (1) AU2010289901A1 (OSRAM)
CA (1) CA2771900A1 (OSRAM)
IN (1) IN2012DN02200A (OSRAM)
TW (1) TW201113372A (OSRAM)
WO (1) WO2011028485A2 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2694088B1 (en) 2011-04-07 2017-06-07 Efranat Ltd. Macrophage activating factor for pharmaceutical compositions
AU2014207429B2 (en) * 2013-01-18 2018-11-01 Ellis KLINE Selective glycosidase regimen for immune programming and treatment of cancer
US12233094B2 (en) 2017-11-29 2025-02-25 Spinalcyte, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
CA3144985A1 (en) 2019-06-27 2020-12-30 The George Washington University, A Congressionally Chartered Not-For-Profit Corporation Hdac6-activated macrophages, compositions, and uses thereof
RU2717218C1 (ru) * 2019-08-07 2020-03-18 Зайцева Инга Николаевна Способ торможения роста подкожного трансплантата экспериментальной глиобластомы человека u-87, перевитого иммунодефицитным мышам nu/j
CN114854579A (zh) * 2022-04-13 2022-08-05 武汉大学 可用于临床的外周血特定亚群细胞外囊泡分离平台

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410269B1 (en) * 1995-06-07 2002-06-25 Nobuto Yamamoto Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
US20050103712A1 (en) * 2003-11-13 2005-05-19 Voyce Brian D. Methods and devices for treating severe peripheral bacterial infections

Also Published As

Publication number Publication date
WO2011028485A3 (en) 2011-07-14
WO2011028485A2 (en) 2011-03-10
IN2012DN02200A (OSRAM) 2015-08-21
EP2467154A2 (en) 2012-06-27
AU2010289901A1 (en) 2012-03-15
TW201113372A (en) 2011-04-16
EP2467154A4 (en) 2013-03-27
US20110123591A1 (en) 2011-05-26
CN102596223A (zh) 2012-07-18

Similar Documents

Publication Publication Date Title
Wang et al. Breakthrough of solid tumor treatment: CAR-NK immunotherapy
Goenka et al. Tumor microenvironment signaling and therapeutics in cancer progression
JP7432624B2 (ja) Nad+及び/又はnad+阻害剤及び/又はnad+アゴニストの使用及びその配合剤
US20230085710A1 (en) Novel polyinosinic - polycytidylic acid compositions
JP2644767B2 (ja) 後生的なグリコシル化最終産物を除去する為の方法及び薬剤
US20110123591A1 (en) Tumoricidal, bactericidal, or viricidal macrophage activation
EP4435101A1 (en) Membrane surface protein containing gpi anchor region
Gardam et al. Targeting the dendritic cell-T cell axis to develop effective immunotherapies for glioblastoma
EP4321536A1 (en) Bispecific antibody and use thereof
Tao et al. New insights into immune cells and immunotherapy for thyroid cancer
US20160206699A1 (en) Use of interleukin 10 mrna transfected macrophages in anti-inflammatory therapies
Tu et al. FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
Zhang et al. Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles
TWI721352B (zh) 含有gm3神經節苷酯作為免疫調節劑之奈米粒子
JP6497827B1 (ja) エイコサノイド産生促進剤
CN109793889B (zh) 一种肿瘤疫苗及其制备方法
CN114762730A (zh) Pcsk9在肿瘤免疫治疗、增强免疫细胞免疫效应中的应用
EP4613852A1 (en) Method for coupling therapeutic molecules to surfaces of mature erythrocytes and use
Oujagir et al. Therapeutic efficacy of in-vivo IL-12 plasmid delivery using microbubble-assisted ultrasound in a B16F10 mouse melanoma model: A proof of concept
Garcia-Martinez et al. Adverse prognosis of GM-CSF expression in human cutaneous melanoma
Kong et al. Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord
US20230134704A1 (en) A method of treating cancer by upregulating cathelicidin gene expression and infusing natural killer cells
CN117143250A (zh) 一种IL-15/IL-15Rα融合基因、载体、工程化脂肪细胞及其制备方法
KR20250162896A (ko) 종양 치료 전계 및 킬러 세포를 사용한 암 치료를 위한 조성물, 시스템, 및 방법
CN113307882A (zh) 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140825

FZDE Discontinued

Effective date: 20140825