CA2767614C - Schemas posologiques de l'acide fusidique pour le traitement d'infections bacteriennes - Google Patents

Schemas posologiques de l'acide fusidique pour le traitement d'infections bacteriennes Download PDF

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Publication number
CA2767614C
CA2767614C CA2767614A CA2767614A CA2767614C CA 2767614 C CA2767614 C CA 2767614C CA 2767614 A CA2767614 A CA 2767614A CA 2767614 A CA2767614 A CA 2767614A CA 2767614 C CA2767614 C CA 2767614C
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dose
administered
hours
administration
formulated
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CA2767614A1 (fr
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Ronald Jones
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Arrevus Inc
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Cempra Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux schémas posologiques pour le traitement et la prévention d?infections bactériennes à l?aide d?acide fusidique. Il a été découvert que l?utilisation d?une dose de charge élevée d?acide fusidique, suivie de doses d?entretien modérées du médicament, prévient le développement de souches de bactéries résistant au médicament, augmente le spectre efficace du médicament, et évite les nausées et vomissements associés à un traitement prolongé avec des quantités élevées du médicament.
CA2767614A 2009-07-13 2009-07-13 Schemas posologiques de l'acide fusidique pour le traitement d'infections bacteriennes Active CA2767614C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/050353 WO2011008193A1 (fr) 2009-07-13 2009-07-13 Schémas posologiques de l’acide fusidique pour le traitement d’infections bactériennes

Publications (2)

Publication Number Publication Date
CA2767614A1 CA2767614A1 (fr) 2011-01-20
CA2767614C true CA2767614C (fr) 2019-01-15

Family

ID=43449613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2767614A Active CA2767614C (fr) 2009-07-13 2009-07-13 Schemas posologiques de l'acide fusidique pour le traitement d'infections bacteriennes

Country Status (2)

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CA (1) CA2767614C (fr)
WO (1) WO2011008193A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2529817C (fr) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
JP5698979B2 (ja) 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
JP5602748B2 (ja) 2008-10-24 2014-10-08 センプラ ファーマシューティカルズ，インコーポレイテッド トリアゾール含有マクロライドを用いた生体防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
US9345717B2 (en) 2013-09-25 2016-05-24 Zavante Therapeutics, Inc. Method for improving drug treatments in mammals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230656B1 (hu) * 1998-09-25 2017-06-28 Cubist Pharmaceuticals Llc Daptomicin alkalmazása
US6991807B2 (en) * 2000-02-24 2006-01-31 Advancis Pharmaceutical, Corp. Antibiotic composition

Also Published As

Publication number Publication date
WO2011008193A1 (fr) 2011-01-20
CA2767614A1 (fr) 2011-01-20

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