CA2763923C - Semi-solid compositions comprising 5-ala esters - Google Patents

Semi-solid compositions comprising 5-ala esters Download PDF

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Publication number
CA2763923C
CA2763923C CA2763923A CA2763923A CA2763923C CA 2763923 C CA2763923 C CA 2763923C CA 2763923 A CA2763923 A CA 2763923A CA 2763923 A CA2763923 A CA 2763923A CA 2763923 C CA2763923 C CA 2763923C
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CA
Canada
Prior art keywords
semi
ala
composition
triglycerides
viscosity enhancers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2763923A
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English (en)
French (fr)
Other versions
CA2763923A1 (en
Inventor
Gry Stensrud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photocure ASA
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of CA2763923A1 publication Critical patent/CA2763923A1/en
Application granted granted Critical
Publication of CA2763923C publication Critical patent/CA2763923C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2763923A 2009-06-11 2010-06-11 Semi-solid compositions comprising 5-ala esters Active CA2763923C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09251537.8 2009-06-11
EP09251537 2009-06-11
PCT/EP2010/003532 WO2010142457A1 (en) 2009-06-11 2010-06-11 Semi-solid compositions and pharmaceutical products

Publications (2)

Publication Number Publication Date
CA2763923A1 CA2763923A1 (en) 2010-12-16
CA2763923C true CA2763923C (en) 2016-09-13

Family

ID=41213323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2763923A Active CA2763923C (en) 2009-06-11 2010-06-11 Semi-solid compositions comprising 5-ala esters

Country Status (21)

Country Link
US (2) US20120136055A1 (US20070167479A1-20070719-C00034.png)
EP (2) EP3042647B1 (US20070167479A1-20070719-C00034.png)
JP (1) JP5840604B2 (US20070167479A1-20070719-C00034.png)
KR (2) KR20170116198A (US20070167479A1-20070719-C00034.png)
CN (1) CN102458388B (US20070167479A1-20070719-C00034.png)
AU (1) AU2010257753B2 (US20070167479A1-20070719-C00034.png)
BR (1) BRPI1010761A2 (US20070167479A1-20070719-C00034.png)
CA (1) CA2763923C (US20070167479A1-20070719-C00034.png)
CL (1) CL2011003094A1 (US20070167479A1-20070719-C00034.png)
DK (1) DK2440199T3 (US20070167479A1-20070719-C00034.png)
ES (2) ES2573085T3 (US20070167479A1-20070719-C00034.png)
HK (1) HK1164163A1 (US20070167479A1-20070719-C00034.png)
HU (1) HUE026911T2 (US20070167479A1-20070719-C00034.png)
MX (1) MX2011013127A (US20070167479A1-20070719-C00034.png)
NZ (1) NZ596943A (US20070167479A1-20070719-C00034.png)
PL (1) PL2440199T3 (US20070167479A1-20070719-C00034.png)
RU (1) RU2526803C2 (US20070167479A1-20070719-C00034.png)
SG (1) SG176688A1 (US20070167479A1-20070719-C00034.png)
SI (1) SI2440199T1 (US20070167479A1-20070719-C00034.png)
WO (1) WO2010142457A1 (US20070167479A1-20070719-C00034.png)
ZA (1) ZA201109126B (US20070167479A1-20070719-C00034.png)

Families Citing this family (24)

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US8992954B2 (en) * 2010-03-01 2015-03-31 Photocure Asa Compositions comprising a derivative of 5-aminolevulinic acid
EP2590714B1 (en) 2010-07-09 2017-03-08 Photocure ASA Devices containing dry compositions for use in photodynamic therapy
KR102057349B1 (ko) 2011-12-19 2019-12-18 포토큐어 에이에스에이 광 조사 기구
CN102670577B (zh) * 2012-05-18 2018-04-13 上海复旦张江生物医药股份有限公司 一种光敏剂组合物、其使用方法及用途
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
CN105120839B (zh) * 2013-02-28 2020-07-28 湖州惠中济世生物科技有限公司 可注射长效局麻药半固体制剂及其组成成分
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
GB201306369D0 (en) 2013-04-09 2013-05-22 Photocure As Irradiation device
EP3137053B1 (en) * 2014-04-30 2020-06-17 Allergan, Inc. Formulations of biologics for intravesical instillation
CZ307444B6 (cs) * 2015-04-22 2018-08-29 Jakub Rak Mukoadhezivní polymerní film pro fotosenzitivní terapii v ústní dutině s obsahem fotosenzitizérů
WO2017103285A1 (en) 2015-12-17 2017-06-22 Photocure Asa Method of photodynamic therapy (pdt) for bladder cancer
GB201522309D0 (en) 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
JP2019512536A (ja) * 2016-03-28 2019-05-16 ヴィダック ファーマ リミテッド 局所投与のための安定な医薬組成物およびその使用
US11039616B2 (en) 2016-05-10 2021-06-22 North Carolina State University Photodynamic compositions, methods of making, and uses thereof
US11884784B2 (en) 2016-05-10 2024-01-30 North Carolina State University Photodynamic compositions, methods of making, and uses thereof
GB2546128A (en) * 2016-09-28 2017-07-12 Photocure Asa Pharamaceutical compositions comprising hexaminolevulinic acid and methods of using the same
CN117022242A (zh) * 2017-05-01 2023-11-10 康明斯有限公司 用于控制混合动力系统中能量产生的系统和方法
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
GB201808571D0 (en) * 2018-05-24 2018-07-11 Douglas Pharmaceuticals Ltd Pharmaceutical compositions
CA3128067A1 (en) 2019-02-13 2020-08-20 Alpheus Medical, Inc. Non-invasive sonodynamic therapy
CN110575612A (zh) * 2019-09-27 2019-12-17 赵志国 女用光动力凝胶封包敷料装置

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Also Published As

Publication number Publication date
BRPI1010761A2 (pt) 2016-03-22
JP2012529452A (ja) 2012-11-22
CN102458388B (zh) 2016-09-28
ES2573085T3 (es) 2016-06-06
KR20170116198A (ko) 2017-10-18
US20150238457A1 (en) 2015-08-27
NZ596943A (en) 2013-09-27
KR101797780B1 (ko) 2017-11-14
CN102458388A (zh) 2012-05-16
EP2440199A1 (en) 2012-04-18
AU2010257753A1 (en) 2012-01-12
US20120136055A1 (en) 2012-05-31
ES2821831T3 (es) 2021-04-27
AU2010257753B2 (en) 2014-09-18
HUE026911T2 (en) 2016-07-28
US9326964B2 (en) 2016-05-03
CA2763923A1 (en) 2010-12-16
SG176688A1 (en) 2012-01-30
HK1164163A1 (zh) 2012-09-21
ZA201109126B (en) 2013-02-27
DK2440199T3 (en) 2016-05-17
SI2440199T1 (sl) 2016-05-31
JP5840604B2 (ja) 2016-01-06
RU2011150919A (ru) 2013-07-20
EP2440199B1 (en) 2016-04-13
KR20120046155A (ko) 2012-05-09
EP3042647A1 (en) 2016-07-13
EP3042647B1 (en) 2020-08-26
MX2011013127A (es) 2012-02-21
RU2526803C2 (ru) 2014-08-27
CL2011003094A1 (es) 2012-07-20
PL2440199T3 (pl) 2016-10-31
WO2010142457A1 (en) 2010-12-16

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