CA2757838C - Synthetic endoxifen for treating mammalian diseases - Google Patents
Synthetic endoxifen for treating mammalian diseases Download PDFInfo
- Publication number
- CA2757838C CA2757838C CA2757838A CA2757838A CA2757838C CA 2757838 C CA2757838 C CA 2757838C CA 2757838 A CA2757838 A CA 2757838A CA 2757838 A CA2757838 A CA 2757838A CA 2757838 C CA2757838 C CA 2757838C
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- CA
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- Prior art keywords
- endoxifen
- acid
- synthetically prepared
- composition
- cholesterol
- Prior art date
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/470,219 | 2009-05-21 | ||
| US12/470,219 US20090291134A1 (en) | 2006-11-21 | 2009-05-21 | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| PCT/US2010/035852 WO2010135703A2 (en) | 2009-05-21 | 2010-05-21 | Endoxifen methods and compositions in the treatment of mammalian diseases |
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| CA2757838A1 CA2757838A1 (en) | 2010-11-25 |
| CA2757838C true CA2757838C (en) | 2013-12-17 |
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| CA2757838A Active CA2757838C (en) | 2009-05-21 | 2010-05-21 | Synthetic endoxifen for treating mammalian diseases |
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| US (3) | US20090291134A1 (enExample) |
| EP (1) | EP2432462A4 (enExample) |
| JP (1) | JP2012527484A (enExample) |
| CA (1) | CA2757838C (enExample) |
| MX (1) | MX2011012409A (enExample) |
| WO (1) | WO2010135703A2 (enExample) |
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| PL2101731T3 (pl) * | 2006-11-21 | 2018-07-31 | Jina Pharmaceuticals Inc. | Endoksyfen do zastosowania w leczeniu nowotworu |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| PT2685979T (pt) | 2011-03-18 | 2016-12-02 | Alkermes Pharma Ireland Ltd | Composições farmacêuticas injetáveis compreendendo um antipsicótico solúvel em água, laurato de sorbitano e polissorbato 20 |
| US10117881B2 (en) * | 2011-06-03 | 2018-11-06 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies |
| GB2507884B (en) | 2011-06-03 | 2019-10-23 | Signpath Pharma Inc | Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current |
| US12004868B2 (en) * | 2011-06-03 | 2024-06-11 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
| US10258691B2 (en) | 2014-06-03 | 2019-04-16 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, EGPG, LysoPG and LysoPC against drugs that cause channelopathies |
| US10349884B2 (en) * | 2011-06-03 | 2019-07-16 | Sighpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel |
| US10238602B2 (en) | 2011-06-03 | 2019-03-26 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies |
| US10449193B2 (en) | 2011-06-03 | 2019-10-22 | Signpath Pharma Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies |
| CA2867123C (en) | 2012-03-19 | 2021-02-16 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters |
| CA2867121C (en) | 2012-03-19 | 2021-05-25 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| NZ630428A (en) | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| JP6262205B2 (ja) * | 2012-04-24 | 2018-01-17 | インターナショナル ステム セル コーポレイション | ヒト多能性幹細胞からの神経幹細胞およびドーパミン作動性ニューロンの誘導方法 |
| EP2668945A1 (de) | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
| AU2013271841B2 (en) * | 2012-06-05 | 2018-03-08 | International Stem Cell Corporation | Method of prevention of neurological diseases |
| WO2014002553A1 (ja) * | 2012-06-29 | 2014-01-03 | 丸石製薬株式会社 | アリピプラゾールの経口医薬製剤 |
| NZ730571A (en) | 2012-09-19 | 2018-12-21 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
| IN2013MU00646A (enExample) * | 2013-03-04 | 2015-06-26 | Intas Pharmaceuticals Ltd | |
| KR101493877B1 (ko) | 2013-03-29 | 2015-02-16 | 농업회사법인 주식회사 생명의나무 | 스피나스테롤 당 유도체를 포함하는 골 질환 예방 또는 치료용 약학 조성물 |
| JP6895252B2 (ja) | 2013-12-18 | 2021-06-30 | サインパス ファルマ, インク.Signpath Pharma, Inc. | 心筋ｉｋｒチャネルの薬剤誘発性阻害のリポソームによる軽減 |
| RU2688233C2 (ru) | 2014-03-20 | 2019-05-21 | Алкермес Фарма Айэленд Лимитед | Препараты арипипразола, имеющие повышенные скорости впрыска |
| EP4220178A3 (en) * | 2014-05-12 | 2023-08-16 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
| CN104892918B (zh) * | 2015-05-29 | 2017-08-25 | 吕常海 | 磷脂酰乙醇胺‑羟基聚乙二醇衍生物及制备方法、脂质体造影剂和治疗肿瘤脂质体诊疗药物 |
| KR102638618B1 (ko) | 2016-04-27 | 2024-02-21 | 사인패스 파마 인코포레이티드 | 약물 유발된 방실 차단의 방지 |
| MX2020002649A (es) * | 2017-09-11 | 2020-09-25 | Atossa Therapeutics Inc | Metodos para hacer y usar endoxifeno. |
| EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| EP3993782A4 (en) | 2019-07-03 | 2023-08-02 | Atossa Therapeutics, Inc. | EXTENDED RELEASE ENDOXIFEN COMPOSITIONS |
| CN119390705A (zh) * | 2019-10-09 | 2025-02-07 | 诺华股份有限公司 | 作为m4激动剂的5-氧杂-2-氮杂螺[3.4]辛烷衍生物 |
| CN115484942A (zh) * | 2020-04-10 | 2022-12-16 | 金纳药业公司 | 因多昔芬用于治疗双相i型障碍 |
| AU2021252229A1 (en) * | 2020-04-10 | 2022-10-27 | Jina Pharmaceuticals, Inc. | Endoxifen for the treatment of bipolar I disorder |
| US12245997B2 (en) | 2020-04-10 | 2025-03-11 | Jina Pharmaceuticals, Inc. | Endoxifen for the treatment of bipolar I disorder |
| US20220031625A1 (en) * | 2020-07-31 | 2022-02-03 | Altaire Pharmaceuticals, Inc. | Ophthalmic compositions for delivering meibum-like materials |
| US20240009259A1 (en) * | 2020-11-20 | 2024-01-11 | Academia Sinica | Use of crassocephalum rabens extract in the prevention and/or treatment of fatigue and/or depression |
| WO2025137145A1 (en) * | 2023-12-18 | 2025-06-26 | Atossa Therapeutics, Inc. | Oral formulations of (z)-endoxifen and methods of use thereof |
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| DE2817157A1 (de) * | 1978-04-17 | 1979-10-25 | Schering Ag | Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| WO1997040679A1 (en) * | 1996-05-01 | 1997-11-06 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US6090407A (en) * | 1997-09-23 | 2000-07-18 | Research Development Foundation | Small particle liposome aerosols for delivery of anti-cancer drugs |
| GB9824207D0 (en) * | 1998-11-04 | 1998-12-30 | Zeneca Ltd | Neurological disorders |
| SE0103839D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Pharmaceutical formulation & product |
| US7968532B2 (en) | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| WO2005105063A1 (en) * | 2004-05-03 | 2005-11-10 | Universita' Degli Studi Di Firenze | Pharmaceutical compositions containing serms for the treatment of alzheimer's disease |
| WO2008127358A2 (en) * | 2006-10-10 | 2008-10-23 | Jina Pharmaceuticals, Inc. | Aqueous systems for the preparation of lipid-based pharmaceutical compounds; compositions, methods, and uses thereof |
| WO2008048194A1 (en) * | 2006-10-20 | 2008-04-24 | Yesilogluj Aysegul Yildiz | Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder |
| US9637515B2 (en) | 2006-11-06 | 2017-05-02 | Jina Pharmaceuticals, Inc. | Guggulphospholipid methods and compositions |
| US20120164075A1 (en) | 2006-11-21 | 2012-06-28 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of mammalian diseases |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| PL2101731T3 (pl) | 2006-11-21 | 2018-07-31 | Jina Pharmaceuticals Inc. | Endoksyfen do zastosowania w leczeniu nowotworu |
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- 2010-05-21 JP JP2012512075A patent/JP2012527484A/ja active Pending
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2019
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| US20190231687A1 (en) | 2019-08-01 |
| EP2432462A2 (en) | 2012-03-28 |
| WO2010135703A3 (en) | 2011-01-13 |
| JP2012527484A (ja) | 2012-11-08 |
| US11672758B2 (en) | 2023-06-13 |
| CA2757838A1 (en) | 2010-11-25 |
| US20090291134A1 (en) | 2009-11-26 |
| MX2011012409A (es) | 2012-03-14 |
| US20210177752A1 (en) | 2021-06-17 |
| EP2432462A4 (en) | 2013-11-13 |
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