CA2756570C - Peptide ligands for clusterin and uses thereof - Google Patents
Peptide ligands for clusterin and uses thereof Download PDFInfo
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- CA2756570C CA2756570C CA2756570A CA2756570A CA2756570C CA 2756570 C CA2756570 C CA 2756570C CA 2756570 A CA2756570 A CA 2756570A CA 2756570 A CA2756570 A CA 2756570A CA 2756570 C CA2756570 C CA 2756570C
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
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- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A61P35/00—Antineoplastic agents
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20291009P | 2009-04-17 | 2009-04-17 | |
| US61/202,910 | 2009-04-17 | ||
| PCT/CA2010/000566 WO2010118521A1 (en) | 2009-04-17 | 2010-04-15 | Peptide ligands for clusterin and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2756570A1 CA2756570A1 (en) | 2010-10-21 |
| CA2756570C true CA2756570C (en) | 2019-04-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2756570A Active CA2756570C (en) | 2009-04-17 | 2010-04-15 | Peptide ligands for clusterin and uses thereof |
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| US (1) | US8629240B2 (enExample) |
| EP (1) | EP2419440B1 (enExample) |
| JP (1) | JP5861242B2 (enExample) |
| AU (1) | AU2010237569B2 (enExample) |
| CA (1) | CA2756570C (enExample) |
| WO (1) | WO2010118521A1 (enExample) |
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| WO2011063523A1 (en) | 2009-11-24 | 2011-06-03 | Alethia Biotherapeutics Inc. | Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume |
| CA2862739A1 (en) | 2012-02-22 | 2013-08-29 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| US10800817B2 (en) | 2016-12-19 | 2020-10-13 | Morehouse School Of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
| CN110312549B (zh) * | 2016-12-19 | 2021-06-29 | 莫尔豪斯医学院 | 用于通过抑制外泌体释放来治疗疾病的组合物和方法 |
| US11180534B1 (en) | 2021-06-04 | 2021-11-23 | Morehouse School Of Medicine | Compositions and methods for treating SARS-CoV-2 infections |
| CN119874833A (zh) * | 2025-01-14 | 2025-04-25 | 广州中医药大学(广州中医药研究院) | Clusterin亲和肽及其修饰的长循环纳米粒的制备方法和应用 |
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| AU9312598A (en) * | 1997-09-10 | 1999-03-29 | Allegheny University Of The Health Sciences | Inhibitors of collagen assembly |
| AU748700B2 (en) * | 1998-06-12 | 2002-06-13 | Aventis Pasteur | HIV virus mimotopes |
| US6348185B1 (en) * | 1998-06-20 | 2002-02-19 | Washington University School Of Medicine | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| US20050208558A1 (en) * | 1999-10-19 | 2005-09-22 | Applera Corporation | Detection kits, such as nucleic acid arrays, for detecting the expression or 10,000 or more Drosophila genes and uses thereof |
| ITRM20040098A1 (it) * | 2004-02-25 | 2004-05-25 | Univ Roma | Anticorpi oligoclonali anticlasterina per la diagnosi di neoplasie e la predizione del loro grado di malignita', metodo diagnostico e kit relativi. |
| JP5376948B2 (ja) * | 2005-09-13 | 2013-12-25 | ナショナル リサーチ カウンシル オブ カナダ | 腫瘍細胞活性を調節する方法及び組成物 |
| US8329399B2 (en) * | 2006-10-27 | 2012-12-11 | Siu K W Michael | Endometrial biomarkers |
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2010
- 2010-04-15 JP JP2012505008A patent/JP5861242B2/ja active Active
- 2010-04-15 US US13/260,676 patent/US8629240B2/en active Active
- 2010-04-15 WO PCT/CA2010/000566 patent/WO2010118521A1/en not_active Ceased
- 2010-04-15 CA CA2756570A patent/CA2756570C/en active Active
- 2010-04-15 EP EP10764019.5A patent/EP2419440B1/en active Active
- 2010-04-15 AU AU2010237569A patent/AU2010237569B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2419440A4 (en) | 2013-04-03 |
| EP2419440B1 (en) | 2015-11-11 |
| JP5861242B2 (ja) | 2016-02-16 |
| US8629240B2 (en) | 2014-01-14 |
| EP2419440A1 (en) | 2012-02-22 |
| AU2010237569A1 (en) | 2011-11-10 |
| US20120121507A1 (en) | 2012-05-17 |
| JP2012524029A (ja) | 2012-10-11 |
| AU2010237569B2 (en) | 2015-04-02 |
| CA2756570A1 (en) | 2010-10-21 |
| WO2010118521A1 (en) | 2010-10-21 |
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