CA2753995A1 - Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 - Google Patents
Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 Download PDFInfo
- Publication number
- CA2753995A1 CA2753995A1 CA2753995A CA2753995A CA2753995A1 CA 2753995 A1 CA2753995 A1 CA 2753995A1 CA 2753995 A CA2753995 A CA 2753995A CA 2753995 A CA2753995 A CA 2753995A CA 2753995 A1 CA2753995 A1 CA 2753995A1
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- Prior art keywords
- epha3
- antibody
- cells
- myeloproliferative disorder
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15828509P | 2009-03-06 | 2009-03-06 | |
| US61/158,285 | 2009-03-06 | ||
| US16813009P | 2009-04-09 | 2009-04-09 | |
| US61/168,130 | 2009-04-09 | ||
| PCT/US2010/026413 WO2010102244A1 (en) | 2009-03-06 | 2010-03-05 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2753995A1 true CA2753995A1 (en) | 2010-09-10 |
Family
ID=42370943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2753995A Abandoned CA2753995A1 (en) | 2009-03-06 | 2010-03-05 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8834870B2 (OSRAM) |
| EP (1) | EP2403879A1 (OSRAM) |
| JP (2) | JP5876728B2 (OSRAM) |
| CN (1) | CN102405237A (OSRAM) |
| AU (1) | AU2010221159B2 (OSRAM) |
| CA (1) | CA2753995A1 (OSRAM) |
| EA (1) | EA201101241A1 (OSRAM) |
| NZ (1) | NZ594950A (OSRAM) |
| WO (1) | WO2010102244A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| JP5781762B2 (ja) * | 2007-08-10 | 2015-09-24 | プロテリックス、インク | ユニバーサルｉｉｉ型フィブロネクチン結合ドメインのライブラリ |
| JP2013508292A (ja) * | 2009-10-14 | 2013-03-07 | カロバイオス ファーマシューティカルズ インコーポレイティッド | ＥｐｈＡ３に対する抗体 |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| WO2012046797A1 (ja) | 2010-10-06 | 2012-04-12 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞集団及びその作製方法 |
| GB201021623D0 (en) * | 2010-12-21 | 2011-02-02 | Isis Innovation | Detection of acute myeloid leukaemia |
| CA2844674A1 (en) * | 2011-08-12 | 2013-02-21 | Kalobios Pharmaceuticals, Inc. | Methods of treating hematological proliferative disorders by targeting epha3 expressed on aberrant vasculature in bone marrow |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| JP6291254B2 (ja) * | 2011-10-28 | 2018-03-14 | 中外製薬株式会社 | 癌幹細胞特異的分子 |
| CA2933960A1 (en) * | 2013-12-17 | 2015-06-25 | Aimm Therapeutics B.V. | Means and methods for counteracting myeloproliferative or lymphoproliferative disorders |
| CN114787190A (zh) * | 2019-10-09 | 2022-07-22 | 昆士兰医学研究所理事会 | 靶向epha3及其用途 |
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| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2230537T3 (es) | 1991-06-21 | 2005-05-01 | The Walter And Eliza Hall Institute Of Medical Research | Una tirosina quinasa de tipo receptor (quinasa de tipo eph/elk hunaba-henki y uso de la misma. |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| NO175798C (no) | 1992-07-22 | 1994-12-07 | Sinvent As | Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
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| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| ES2278463T3 (es) | 1998-12-08 | 2007-08-01 | Biovation Limited | Metodo para reducir la inmunogenicidad de proteinas. |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
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| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1163339A1 (en) | 1999-04-01 | 2001-12-19 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| ES2568899T3 (es) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| EP1094110A1 (en) | 1999-10-21 | 2001-04-25 | Leadd B.V. | Apoptosis inducing proteinaceous substance |
| DE60114830T2 (de) | 2000-06-28 | 2006-08-03 | Glycofi, Inc. | Verfahren zur herstellung modifizierter glycoproteine |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| EP1331266B1 (en) | 2000-10-06 | 2017-01-04 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| EP1333032A4 (en) | 2000-10-06 | 2005-03-16 | Kyowa Hakko Kogyo Kk | PROCESS FOR PURIFYING ANTIBODY |
| DK1355919T3 (da) | 2000-12-12 | 2011-03-14 | Medimmune Llc | Molekyler med længere halveringstider, sammensætninger og anvendelser deraf |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2799805C (en) | 2002-03-19 | 2016-05-17 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| KR100980065B1 (ko) | 2002-09-27 | 2010-09-03 | 젠코어 인코포레이티드 | 최적화된 Ｆｃ 변이체 및 그의 제조 방법 |
| AU2003900541A0 (en) * | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
| JP4782700B2 (ja) | 2004-01-20 | 2011-09-28 | カロバイオス ファーマシューティカルズ インコーポレイティッド | 最低限必須な結合決定基を用いた抗体特異性の移入 |
| EP1778726A4 (en) | 2004-08-16 | 2009-03-18 | Medimmune Inc | INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY |
| WO2006052409A2 (en) * | 2004-10-23 | 2006-05-18 | Case Western Reserve University | Peptide and small molecule agonists of epha and their uses |
| EP1824987B1 (en) | 2004-11-16 | 2013-08-21 | KaloBios Pharmaceuticals, Inc. | Immunoglobulin variable region cassette exchange |
| MX2008009220A (es) | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| AU2008226905C1 (en) * | 2007-03-08 | 2014-11-06 | Humanigen, Inc. | EphA3 antibodies for the treatment of solid tumors |
-
2010
- 2010-03-05 JP JP2011553146A patent/JP5876728B2/ja not_active Expired - Fee Related
- 2010-03-05 EP EP10708675A patent/EP2403879A1/en not_active Withdrawn
- 2010-03-05 AU AU2010221159A patent/AU2010221159B2/en not_active Ceased
- 2010-03-05 CN CN2010800176719A patent/CN102405237A/zh active Pending
- 2010-03-05 US US12/718,768 patent/US8834870B2/en active Active
- 2010-03-05 CA CA2753995A patent/CA2753995A1/en not_active Abandoned
- 2010-03-05 EA EA201101241A patent/EA201101241A1/ru unknown
- 2010-03-05 NZ NZ594950A patent/NZ594950A/xx not_active IP Right Cessation
- 2010-03-05 WO PCT/US2010/026413 patent/WO2010102244A1/en not_active Ceased
-
2014
- 2014-08-29 US US14/473,821 patent/US20140370010A1/en not_active Abandoned
-
2015
- 2015-06-18 JP JP2015122537A patent/JP2015231994A/ja active Pending
-
2016
- 2016-09-14 US US15/265,625 patent/US20170226227A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100226930A1 (en) | 2010-09-09 |
| US8834870B2 (en) | 2014-09-16 |
| JP2012519707A (ja) | 2012-08-30 |
| US20140370010A1 (en) | 2014-12-18 |
| JP2015231994A (ja) | 2015-12-24 |
| WO2010102244A1 (en) | 2010-09-10 |
| JP5876728B2 (ja) | 2016-03-02 |
| CN102405237A (zh) | 2012-04-04 |
| US20170226227A1 (en) | 2017-08-10 |
| AU2010221159B2 (en) | 2015-11-26 |
| EA201101241A1 (ru) | 2012-04-30 |
| NZ594950A (en) | 2013-06-28 |
| AU2010221159A1 (en) | 2011-09-22 |
| EP2403879A1 (en) | 2012-01-11 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150223 |
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| FZDE | Discontinued |
Effective date: 20170608 |