CA2749126C - Conjugues oligomere-phenothiazine - Google Patents
Conjugues oligomere-phenothiazine Download PDFInfo
- Publication number
- CA2749126C CA2749126C CA2749126A CA2749126A CA2749126C CA 2749126 C CA2749126 C CA 2749126C CA 2749126 A CA2749126 A CA 2749126A CA 2749126 A CA2749126 A CA 2749126A CA 2749126 C CA2749126 C CA 2749126C
- Authority
- CA
- Canada
- Prior art keywords
- oligomer
- promethazine
- group
- phenothiazine
- dcm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La présente invention concerne (entre autres) des conjugués oligomère-phénothiazine et des composés associés. Un conjugué selon l'invention, lorsqu'il est administré par une quelconque parmi une pluralité de voies d'administration, présente des avantages par rapport aux composés de phénothiazine non conjugués.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14801609P | 2009-01-28 | 2009-01-28 | |
US61/148,016 | 2009-01-28 | ||
PCT/US2010/022342 WO2010088340A1 (fr) | 2009-01-28 | 2010-01-28 | Conjugués oligomère-phénothiazine |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2749126A1 CA2749126A1 (fr) | 2010-08-05 |
CA2749126C true CA2749126C (fr) | 2017-08-22 |
Family
ID=42101449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2749126A Active CA2749126C (fr) | 2009-01-28 | 2010-01-28 | Conjugues oligomere-phenothiazine |
Country Status (8)
Country | Link |
---|---|
US (3) | US20120046279A1 (fr) |
EP (1) | EP2391386B1 (fr) |
JP (1) | JP5828587B2 (fr) |
CN (1) | CN102300588B (fr) |
AU (1) | AU2010208274B2 (fr) |
CA (1) | CA2749126C (fr) |
MX (1) | MX2011007940A (fr) |
WO (1) | WO2010088340A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010005813A (es) * | 2007-11-28 | 2010-06-15 | Nektar Therapeutics | Conjugados oligomero-triciclicos. |
CA2749126C (fr) | 2009-01-28 | 2017-08-22 | Nektar Therapeutics | Conjugues oligomere-phenothiazine |
WO2011091050A1 (fr) * | 2010-01-19 | 2011-07-28 | Nektar Therapeutics | Conjugués oligomères-tricycliques |
EP2758403B1 (fr) | 2011-09-21 | 2016-04-27 | Inception Orion, Inc. | Composés tricycliques utiles comme agents neurogènes et neuroprotecteurs |
JP6265998B2 (ja) | 2012-09-17 | 2018-01-24 | ネクター セラピューティクス | オリゴマー含有ベンズアミド系化合物 |
US9695138B1 (en) * | 2016-10-17 | 2017-07-04 | Acenda Pharma, Inc. | Phenothiazine derivatives and methods of use thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2530451A (en) | 1950-11-21 | Phenothiazines | ||
US2519886A (en) | 1950-08-22 | Beta-bimethylaminoethylphenothia | ||
US2607773A (en) | 1952-08-19 | Processes for preparing phenthi- | ||
GB641452A (en) | 1946-12-09 | 1950-08-09 | Rhone Poulenc Sa | Improvements in or relating to the preparation of derivatives of phenthiazine |
US3987042A (en) | 1969-03-03 | 1976-10-19 | Claude Gueremy | Phenothiazine derivative |
FR2632521B1 (fr) | 1988-06-10 | 1990-09-14 | Rhone Poulenc Sante | Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
EP1360180A1 (fr) | 2001-01-19 | 2003-11-12 | Cytokinetics, Inc. | Inhibiteurs de la kinesine a base de phenothiazine |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
WO2003002150A1 (fr) | 2001-06-28 | 2003-01-09 | Wyeth | Composition et procede permettant de reduire des interactions nefastes entre des derives de phenothiazine et du plasma |
US20050080075A1 (en) * | 2003-08-25 | 2005-04-14 | Nichols M. James | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
CA2758460C (fr) | 2003-12-16 | 2014-09-23 | Nektar Therapeutics | Methodes de preparation de compositions de reactifs oligo (ethylene glycol) monodisperses |
US20080112257A1 (en) * | 2006-11-10 | 2008-05-15 | Masatoshi Masuda | Mixing device for tub |
EP2121031B1 (fr) * | 2007-03-12 | 2013-10-16 | Nektar Therapeutics | Conjugués d'oligomère antihistaminique |
CA2749126C (fr) | 2009-01-28 | 2017-08-22 | Nektar Therapeutics | Conjugues oligomere-phenothiazine |
-
2010
- 2010-01-28 CA CA2749126A patent/CA2749126C/fr active Active
- 2010-01-28 WO PCT/US2010/022342 patent/WO2010088340A1/fr active Application Filing
- 2010-01-28 EP EP10703204.7A patent/EP2391386B1/fr active Active
- 2010-01-28 MX MX2011007940A patent/MX2011007940A/es active IP Right Grant
- 2010-01-28 JP JP2011548281A patent/JP5828587B2/ja active Active
- 2010-01-28 US US13/146,612 patent/US20120046279A1/en not_active Abandoned
- 2010-01-28 AU AU2010208274A patent/AU2010208274B2/en active Active
- 2010-01-28 CN CN201080005673.6A patent/CN102300588B/zh active Active
-
2018
- 2018-05-01 US US15/968,561 patent/US10485877B2/en active Active
-
2019
- 2019-10-11 US US16/599,605 patent/US10869933B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2391386A1 (fr) | 2011-12-07 |
US20120046279A1 (en) | 2012-02-23 |
MX2011007940A (es) | 2011-08-15 |
US10485877B2 (en) | 2019-11-26 |
CA2749126A1 (fr) | 2010-08-05 |
CN102300588A (zh) | 2011-12-28 |
JP2012516347A (ja) | 2012-07-19 |
EP2391386B1 (fr) | 2018-06-27 |
US20180243429A1 (en) | 2018-08-30 |
AU2010208274A1 (en) | 2011-07-21 |
JP5828587B2 (ja) | 2015-12-09 |
US20200038517A1 (en) | 2020-02-06 |
CN102300588B (zh) | 2014-07-16 |
WO2010088340A1 (fr) | 2010-08-05 |
AU2010208274B2 (en) | 2015-11-05 |
US10869933B2 (en) | 2020-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20141110 |