CA2743610C - Fibroblast growth factor-9 promotes hair follicle regeneration after wounding - Google Patents

Fibroblast growth factor-9 promotes hair follicle regeneration after wounding Download PDF

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Publication number
CA2743610C
CA2743610C CA2743610A CA2743610A CA2743610C CA 2743610 C CA2743610 C CA 2743610C CA 2743610 A CA2743610 A CA 2743610A CA 2743610 A CA2743610 A CA 2743610A CA 2743610 C CA2743610 C CA 2743610C
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Prior art keywords
subject
administering
another embodiment
disrupting
hair
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CA2743610A
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English (en)
French (fr)
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CA2743610A1 (en
Inventor
George Cotsarelis
Ohsang Kwon
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University of Pennsylvania
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University of Pennsylvania
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Publication of CA2743610A1 publication Critical patent/CA2743610A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
CA2743610A 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding Active CA2743610C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11402808P 2008-11-12 2008-11-12
US61/114,028 2008-11-12
PCT/US2009/064049 WO2010056759A1 (en) 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding

Publications (2)

Publication Number Publication Date
CA2743610A1 CA2743610A1 (en) 2010-05-20
CA2743610C true CA2743610C (en) 2021-04-27

Family

ID=42170304

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2743610A Active CA2743610C (en) 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding

Country Status (9)

Country Link
US (4) US8871711B2 (enExample)
EP (2) EP3144034A1 (enExample)
JP (1) JP5723780B2 (enExample)
KR (2) KR20170024148A (enExample)
AU (2) AU2009314147B2 (enExample)
BR (1) BRPI0915262B1 (enExample)
CA (1) CA2743610C (enExample)
IL (2) IL212858A (enExample)
WO (1) WO2010056759A1 (enExample)

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ES2931949T3 (es) 2005-03-29 2023-01-05 Univ Pennsylvania Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie
KR20170024148A (ko) * 2008-11-12 2017-03-06 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 손상된 모낭의 재생을 촉진하는 섬유모세포 성장 인자-9
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
JP5945540B2 (ja) 2010-08-27 2016-07-05 シエナ バイオファーマシューティカルズ，インク． 標的とされた熱変調のための組成物及び方法
GB2485475A (en) * 2010-11-10 2012-05-16 Pangaea Lab Ltd Topical growth factor application using controlled and multiple wounding of the skin
JP2014500275A (ja) 2010-12-06 2014-01-09 フォリカ，インコーポレイテッド 禿頭症を治療するため、および毛髪の成長を促進するための方法
DK2906286T3 (en) 2012-10-11 2017-07-17 Nanocomposix Inc SILVER CHARACTER COMPOSITIONS AND PROCEDURES
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods
KR101578901B1 (ko) 2013-09-11 2015-12-28 (주)셀아이콘랩 발모 촉진 펩타이드, 이의 제조방법, 및, 이를 함유하는 탈모방지 또는 발모촉진용 조성물
WO2015164800A2 (en) * 2014-04-24 2015-10-29 University Of Central Florida Research Foundation, Inc. Compositions and methods for modulating polarization of monocytes
KR101841482B1 (ko) * 2016-02-25 2018-03-23 (주)피앤피바이오팜 안정성이 증가된 인간 섬유아세포 성장인자-9 변이체 및 이의 용도
KR102535575B1 (ko) * 2016-02-26 2023-05-23 (주)피앤피바이오팜 고안정성 섬유아세포 성장인자-9 변이체를 유효성분으로 포함하는 헤어케어 화장품 조성물
CN111356447B (zh) * 2017-11-16 2023-03-24 艾维塔生物医学公司 细胞膜结合信号传导因子的用途
CN110551692B (zh) * 2019-07-09 2021-06-25 吕贯廷 hFGF9基因修饰型间充质干细胞及其制备方法和用途
EP4149474A4 (en) * 2020-05-12 2024-10-09 Chemistryrx METHODS OF TREATING HAIR LOSS AND RELATED COMPOSITIONS
WO2022150415A1 (en) * 2021-01-06 2022-07-14 The Penn State Research Foundation Methods and materials for treating hair loss
MX2023008826A (es) 2021-02-01 2023-09-15 Regenxbio Inc Terapia génica para lipofuscinosis neuronal ceroidea.
US12268677B2 (en) 2022-04-27 2025-04-08 The Penn State Research Foundation 4-aminopyridine (4-AP) and bone morphogenetic protein 2 (BMP-2)
JP2026520082A (ja) * 2023-04-12 2026-06-22 エステトラ エスアールエル 毛の成長を促進するための外用組成物
CN118286487B (zh) * 2024-04-01 2024-09-17 吉林农业大学 一种促进复杂感染伤口愈合的多功能纳米纤维膜的制备方法
CN118161418B (zh) * 2024-05-14 2024-07-23 美归(成都)生物材料合伙企业(有限合伙) 保湿美白脂质体精华液及其制备方法

Family Cites Families (15)

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JPH04224522A (ja) 1990-04-27 1992-08-13 Merck & Co Inc 繊維芽細胞増殖因子含有組成物による禿頭症の治療又は予防方法
JPH10279501A (ja) 1997-02-10 1998-10-20 Rohto Pharmaceut Co Ltd 育毛剤
US20070009544A1 (en) * 1999-06-17 2007-01-11 Ronit Eisenberg Anti-allergic complex molecules
DE60129799T2 (de) * 2000-03-31 2008-04-30 The General Hospital Corp., Boston Verfahren zur steigerung des haarwuchses durch wnt polypeptid
US7588937B2 (en) * 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
JP2003192541A (ja) * 2001-12-26 2003-07-09 Pola Chem Ind Inc 育毛促進剤及び育毛用の皮膚外用剤
US20070299032A1 (en) 2003-11-11 2007-12-27 Shiseido Company, Ltd. Method and Composition for Thickening Hair
ES2931949T3 (es) * 2005-03-29 2023-01-05 Univ Pennsylvania Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie
MX2008004928A (es) 2005-10-17 2008-09-12 Aderans Res Inst Inc Metodo para suministrar celulas progenitoras de foliculo piloso a la piel.
US20070122387A1 (en) 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair grafts derived from plucked hair
US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules
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Also Published As

Publication number Publication date
JP2012508750A (ja) 2012-04-12
IL212858A (en) 2016-12-29
KR101711995B1 (ko) 2017-03-06
WO2010056759A1 (en) 2010-05-20
EP3144034A1 (en) 2017-03-22
KR20170024148A (ko) 2017-03-06
US20110282267A1 (en) 2011-11-17
CA2743610A1 (en) 2010-05-20
US8871711B2 (en) 2014-10-28
US20180280475A1 (en) 2018-10-04
EP2361119A1 (en) 2011-08-31
AU2009314147B2 (en) 2015-12-24
IL249309A0 (en) 2017-01-31
EP2361119B1 (en) 2018-09-19
US20150216934A1 (en) 2015-08-06
IL212858A0 (en) 2011-07-31
BRPI0915262B1 (pt) 2018-06-05
AU2016201796A1 (en) 2016-05-05
BRPI0915262A2 (pt) 2016-02-16
AU2009314147A1 (en) 2010-05-20
KR20110092301A (ko) 2011-08-17
JP5723780B2 (ja) 2015-05-27
US20200197488A1 (en) 2020-06-25
EP2361119A4 (en) 2014-01-08

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