CA2743032A1 - Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes - Google Patents

Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes Download PDF

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Publication number
CA2743032A1
CA2743032A1 CA2743032A CA2743032A CA2743032A1 CA 2743032 A1 CA2743032 A1 CA 2743032A1 CA 2743032 A CA2743032 A CA 2743032A CA 2743032 A CA2743032 A CA 2743032A CA 2743032 A1 CA2743032 A1 CA 2743032A1
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CA
Canada
Prior art keywords
antibody
alpha
sequences
antibodies
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2743032A
Other languages
English (en)
French (fr)
Inventor
Marja-Leena Laukkanen
Kristiina Takkinen
Jari Natunen
Tero Satomaa
Jaakko Parkkinen
Leena Valmu
Sari Tiitinen
Suvi Natunen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suomen Punainen Risti Veripalvelu
Glykos Finland Ltd
Original Assignee
Suomen Punainen Risti Veripalvelu
Glykos Finland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suomen Punainen Risti Veripalvelu, Glykos Finland Ltd filed Critical Suomen Punainen Risti Veripalvelu
Publication of CA2743032A1 publication Critical patent/CA2743032A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2743032A 2007-11-09 2008-11-10 Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes Abandoned CA2743032A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20070853A FI20070853A0 (fi) 2007-11-09 2007-11-09 Glykaania sitovat monoklonaaliset vasta-aineet
FI20070853 2007-11-09
PCT/FI2008/050643 WO2009060129A1 (en) 2007-11-09 2008-11-10 Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes

Publications (1)

Publication Number Publication Date
CA2743032A1 true CA2743032A1 (en) 2009-05-14

Family

ID=38786638

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2743032A Abandoned CA2743032A1 (en) 2007-11-09 2008-11-10 Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes

Country Status (7)

Country Link
US (1) US20100292095A1 (https=)
EP (1) EP2209809A4 (https=)
JP (1) JP2011504099A (https=)
AU (1) AU2008324073A1 (https=)
CA (1) CA2743032A1 (https=)
FI (1) FI20070853A0 (https=)
WO (1) WO2009060129A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT110526A (pt) * 2018-01-26 2019-07-26 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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FI20095418A0 (fi) * 2009-04-16 2009-04-16 Suomen Punainen Risti Veripalv Kryptinen subpopulaatio
WO2010044131A1 (ja) * 2008-10-13 2010-04-22 三菱電機株式会社 リソース割り当て装置及びリソース割り当てプログラム及び記録媒体及びリソース割り当て方法
WO2013151649A1 (en) * 2012-04-04 2013-10-10 Sialix Inc Glycan-interacting compounds
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
FI3218005T3 (fi) 2014-11-12 2023-03-31 Seagen Inc Glykaanin kanssa vuorovaikutteisia yhdisteitä ja käyttömenetelmiä
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
JP2019503985A (ja) * 2015-11-03 2019-02-14 グリコミメティクス， インコーポレイテッド モノクローナル抗体、造血幹細胞の産生のための方法および組成物、ならびにそれらを使用する方法
CA3002097A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Crescent Biopharma, Inc. Highly potent multimeric E-selectin antagonists
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
GB201703212D0 (en) * 2017-02-28 2017-04-12 Nat Univ Ireland Galway The detectionm quantification and discrimination of the sialic acid N-glycolylneuraminic (Neu5Gc) acid and N-acetylneuraminic acid (Neu5gc)
WO2018160909A1 (en) 2017-03-03 2018-09-07 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
MX2021002761A (es) * 2018-09-10 2021-05-31 Cold Spring Harbor Laboratory Metodos para tratar la pancreatitis.
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342566A (en) * 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4965198A (en) * 1985-12-24 1990-10-23 Konica Corporation Monoclonal antibody and method of manufacturing hybridoma producing the same
US4949778A (en) * 1987-12-16 1990-08-21 Kawasaki Steel Corporation Immersion nozzle for continuous casting
DE4208795A1 (de) * 1992-03-19 1993-09-23 Behringwerke Ag Monoklonaler anti-gangliosid-antikoerper, seine herstellung und verwendung als tumortherapeutikum
EP2261255A1 (en) * 2003-07-15 2010-12-15 The Regents of The University of California Methods for purifying sialic acid-specific antibodies and composition comprising affinity-purified antibodies
FI20055398A0 (fi) * 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
WO2007054622A1 (en) * 2005-11-08 2007-05-18 Suomen Punainen Risti, Veripalvelu Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof
CA2692445A1 (en) * 2006-06-29 2008-01-03 Glykos Finland Oy Novel cellular glycan compositions
EP2115460A4 (en) * 2007-01-18 2010-01-13 Suomen Punainen Risti Veripalv NEW CARBOHYDRATE FROM HUMAN CELLS AND METHOD FOR THE ANALYSIS AND MODIFICATION THEREOF
WO2008087259A1 (en) * 2007-01-18 2008-07-24 Suomen Punainen Risti, Veripalvelu Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof
JP2010516241A (ja) * 2007-01-18 2010-05-20 スオメン プナイネン リスティ，ヴェリパルベル 新規の特異的細胞結合剤

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT110526A (pt) * 2018-01-26 2019-07-26 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais
WO2019147152A1 (en) 2018-01-26 2019-08-01 Universidade Nova De Lisboa L2a5 antibody or functional fragment thereof against tumour antigens
PT110526B (pt) * 2018-01-26 2021-02-04 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais

Also Published As

Publication number Publication date
JP2011504099A (ja) 2011-02-03
AU2008324073A1 (en) 2009-05-14
US20100292095A1 (en) 2010-11-18
WO2009060129A1 (en) 2009-05-14
FI20070853A0 (fi) 2007-11-09
EP2209809A4 (en) 2011-03-30
EP2209809A1 (en) 2010-07-28

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Effective date: 20131113