CA2742517A1 - Hla-g proteins and pharmaceutical uses thereof - Google Patents
Hla-g proteins and pharmaceutical uses thereof Download PDFInfo
- Publication number
- CA2742517A1 CA2742517A1 CA2742517A CA2742517A CA2742517A1 CA 2742517 A1 CA2742517 A1 CA 2742517A1 CA 2742517 A CA2742517 A CA 2742517A CA 2742517 A CA2742517 A CA 2742517A CA 2742517 A1 CA2742517 A1 CA 2742517A1
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- Prior art keywords
- hla
- polypeptide
- sequence
- domain
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Toxicology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168675.0 | 2008-11-07 | ||
| EP08168675A EP2184070A1 (en) | 2008-11-07 | 2008-11-07 | HLA-G proteins and pharmaceutical uses thereof |
| US11280408P | 2008-11-10 | 2008-11-10 | |
| US61/112,804 | 2008-11-10 | ||
| PCT/EP2009/064575 WO2010052228A1 (en) | 2008-11-07 | 2009-11-04 | Hla-g proteins and pharmaceutical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2742517A1 true CA2742517A1 (en) | 2010-05-14 |
Family
ID=40673439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2742517A Abandoned CA2742517A1 (en) | 2008-11-07 | 2009-11-04 | Hla-g proteins and pharmaceutical uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110268737A1 (ja) |
| EP (2) | EP2184070A1 (ja) |
| JP (1) | JP2012507994A (ja) |
| CA (1) | CA2742517A1 (ja) |
| DK (1) | DK2352509T3 (ja) |
| ES (1) | ES2423993T3 (ja) |
| PT (1) | PT2352509E (ja) |
| WO (1) | WO2010052228A1 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2765801A1 (en) * | 2009-06-18 | 2010-12-23 | Hla-G Technologies | Hla-g alpha 1 multimers and pharmaceutical uses thereof |
| JP5736368B2 (ja) * | 2009-06-25 | 2015-06-17 | コミッサリア ア レネルジ アトミック エ オー エネルジ アルターネイティブスＣｏｍｍｉｓｓａｒｉａｔ Ａ Ｌ’Ｅｎｅｒｇｉｅ Ａｔｏｍｉｑｕｅ Ｅｔ Ａｕｘ Ｅｎｅｒｇｉｅｓ Ａｌｔｅｒｎａｔｉｖｅｓ | 少なくとも２つのα３ドメインを含むＨＬＡ−Ｇの多量体ポリペプチド及び医薬としてのその使用 |
| SI2802668T1 (sl) * | 2012-01-12 | 2019-01-31 | Bioverativ Therapeutics Inc. | Zmanjšanje imunogeničnosti proti faktorju VIII pri posameznikih, ki se zdravijo zaradi faktorja VIII |
| KR20150037959A (ko) | 2012-08-02 | 2015-04-08 | 에프. 호프만-라 로슈 아게 | 단량체 및 다량체 분자의 제조 방법 및 이의 용도 |
| CA2894511C (en) | 2012-12-11 | 2021-12-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for high throughput receptor:ligand identification |
| US20170176435A1 (en) * | 2014-01-21 | 2017-06-22 | Albert Einstein College Of Medicine, Inc. | Cellular platform for rapid and comprehensive t-cell immunomonitoring |
| JP6416480B2 (ja) * | 2014-01-29 | 2018-10-31 | 国立大学法人北海道大学 | 関節リウマチまたはその関連疾患の予防または治療剤 |
| US9765330B1 (en) | 2015-01-09 | 2017-09-19 | Nant Holdings Ip, Llc | Compositions and methods for reduction of allograft recognition and rejection |
| IL262606B2 (en) | 2016-05-18 | 2023-04-01 | Albert Einstein College Medicine Inc | pd-l1 variant polypeptides, T-cell modulatory multimeric polypeptides, and methods of using them |
| EP3458096A4 (en) | 2016-05-18 | 2019-11-27 | Cue Biopharma, Inc. | T-LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES AND METHODS OF USE |
| EA201892793A1 (ru) | 2016-06-03 | 2019-06-28 | Инвектис | Анти-hla-g специфические антитела |
| KR20190017985A (ko) * | 2016-06-14 | 2019-02-20 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직, 및 장기 |
| SI3558339T1 (sl) | 2016-12-22 | 2024-05-31 | Cue Biopharma, Inc. | Celico T modulirajoči multimerni polipeptidi in postopki njihove uporabe |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF |
| JP2021080171A (ja) * | 2018-03-13 | 2021-05-27 | 国立大学法人北海道大学 | 改変タンパク質、医薬品、炎症性疾患の予防又は治療剤及び改変タンパク質の製造方法 |
| KR20230009872A (ko) | 2020-05-12 | 2023-01-17 | 큐 바이오파마, 인크. | 다량체 t-세포 조절 폴리펩타이드 및 이의 사용 방법 |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma Inc | MHC CLASS II T-CELL MODULATING MULTIMER POLYPEPTIDES FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717498B1 (fr) | 1994-03-18 | 1996-05-03 | Commissariat Energie Atomique | Transcrits du gène de CMH de classe I HLA-G et leurs applications. |
| EP1054688B1 (fr) | 1998-02-20 | 2004-06-30 | Commissariat A L'energie Atomique | Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications |
| FR2794977B1 (fr) | 1999-06-18 | 2003-10-31 | Commissariat Energie Atomique | Utilisation de compositions contenant des formes solubles d'hla-g dans le traitement de pathologies inflammatoires de la peau, et leur procede d'obtention |
| FR2810047B1 (fr) | 2000-06-13 | 2004-04-02 | Commissariat Energie Atomique | Nouvelle isoforme d'hla-g et ses applications |
| WO2005063808A1 (en) * | 2003-12-31 | 2005-07-14 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| EP1755645A2 (en) * | 2004-06-18 | 2007-02-28 | Regeneron Pharmaceuticals, Inc. | Vegf inhibitors for the treatment of malignant pleural effusion |
| WO2007011044A1 (ja) | 2005-07-15 | 2007-01-25 | Kyushu University, National University Corporation | ジスルフィド結合型hla-g二量体を含む医薬組成物及びジスルフィド結合型hla-g二量体の製造方法 |
| WO2007091078A2 (en) | 2006-02-10 | 2007-08-16 | Axordia Limited | Polypeptide conjugate comprising hla-g and uses thereof, stem cells transfected with hla-g |
| AU2007249709A1 (en) * | 2006-05-15 | 2007-11-22 | Viral Logic Systems Technology Corp. | CD47 related compositions and methods for treating immunological diseases and disorders |
-
2008
- 2008-11-07 EP EP08168675A patent/EP2184070A1/en not_active Withdrawn
-
2009
- 2009-11-04 DK DK09747827.5T patent/DK2352509T3/da active
- 2009-11-04 ES ES09747827T patent/ES2423993T3/es active Active
- 2009-11-04 PT PT97478275T patent/PT2352509E/pt unknown
- 2009-11-04 US US13/127,788 patent/US20110268737A1/en not_active Abandoned
- 2009-11-04 JP JP2011535101A patent/JP2012507994A/ja active Pending
- 2009-11-04 EP EP09747827.5A patent/EP2352509B1/en not_active Not-in-force
- 2009-11-04 WO PCT/EP2009/064575 patent/WO2010052228A1/en active Application Filing
- 2009-11-04 CA CA2742517A patent/CA2742517A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2352509A1 (en) | 2011-08-10 |
| EP2184070A1 (en) | 2010-05-12 |
| EP2352509B1 (en) | 2013-05-15 |
| US20110268737A1 (en) | 2011-11-03 |
| JP2012507994A (ja) | 2012-04-05 |
| DK2352509T3 (da) | 2013-08-12 |
| PT2352509E (pt) | 2013-08-27 |
| ES2423993T3 (es) | 2013-09-26 |
| WO2010052228A1 (en) | 2010-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20151104 |