CA2740056A1 - Methods and compositions for treating mammalian nerve tissue injuries - Google Patents
Methods and compositions for treating mammalian nerve tissue injuries Download PDFInfo
- Publication number
- CA2740056A1 CA2740056A1 CA2740056A CA2740056A CA2740056A1 CA 2740056 A1 CA2740056 A1 CA 2740056A1 CA 2740056 A CA2740056 A CA 2740056A CA 2740056 A CA2740056 A CA 2740056A CA 2740056 A1 CA2740056 A1 CA 2740056A1
- Authority
- CA
- Canada
- Prior art keywords
- glycol
- injury
- fusion agent
- peg
- spinal cord
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28620001P | 2001-04-24 | 2001-04-24 | |
| US60/286,200 | 2001-04-24 | ||
| CA2445612A CA2445612C (en) | 2001-04-24 | 2002-04-24 | Methods and compositions for treating mammalian nerve tissue injuries |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2445612A Division CA2445612C (en) | 2001-04-24 | 2002-04-24 | Methods and compositions for treating mammalian nerve tissue injuries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2740056A1 true CA2740056A1 (en) | 2002-11-21 |
Family
ID=23097525
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2740056A Abandoned CA2740056A1 (en) | 2001-04-24 | 2002-04-24 | Methods and compositions for treating mammalian nerve tissue injuries |
| CA2445612A Expired - Fee Related CA2445612C (en) | 2001-04-24 | 2002-04-24 | Methods and compositions for treating mammalian nerve tissue injuries |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2445612A Expired - Fee Related CA2445612C (en) | 2001-04-24 | 2002-04-24 | Methods and compositions for treating mammalian nerve tissue injuries |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7837987B2 (enExample) |
| EP (1) | EP1389121B1 (enExample) |
| JP (2) | JP2004527573A (enExample) |
| AT (1) | ATE546146T1 (enExample) |
| AU (2) | AU2002314758B2 (enExample) |
| CA (2) | CA2740056A1 (enExample) |
| ES (1) | ES2382899T3 (enExample) |
| NZ (2) | NZ543953A (enExample) |
| WO (1) | WO2002092107A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7582680B1 (en) | 1998-11-12 | 2009-09-01 | Purdue Research Foundation | Methods and compositions for treating mammalian spinal cord injuries |
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| US7276580B2 (en) * | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
| NZ543953A (en) * | 2001-04-24 | 2007-04-27 | Univ Chicago | Method and compositions for treating mammalian nerve tissue injuries |
| US7147647B2 (en) | 2002-04-26 | 2006-12-12 | Medtronic, Inc. | Sintered titanium tube for the management of spinal cord injury |
| JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| NZ543365A (en) | 2003-04-18 | 2009-02-28 | Biogen Idec Inc | Polymer-conjugated glycosylated neublastin |
| EP1786454B1 (en) * | 2004-08-19 | 2010-07-21 | Biogen Idec MA Inc. | Neublastin variants |
| DE602005022082D1 (de) * | 2004-08-19 | 2010-08-12 | Biogen Idec Inc | Rückfaltung von proteinen der transforming-growth-factor-beta-familie |
| US20060121016A1 (en) * | 2004-10-18 | 2006-06-08 | Lee Raphael C | Methods and compositions for treatment of free radical injury |
| CN101084272B (zh) * | 2004-12-21 | 2011-07-13 | 路博润有限公司 | 组合物 |
| US20070048731A1 (en) * | 2005-05-20 | 2007-03-01 | Neurosilicon | High throughput use-dependent assay based on stimulation of cells on a silicon surface |
| WO2006130599A2 (en) * | 2005-05-31 | 2006-12-07 | Warsaw Orthopedic, Inc. | Compositions and methods for treating a damaged cardiovascular element |
| US20070017530A1 (en) * | 2005-06-10 | 2007-01-25 | Syed Naweed I | Detecting electrical activity and assessing agents for the ability to influence electrical activity |
| US20060287660A1 (en) * | 2005-06-15 | 2006-12-21 | Syed Naweed I | Electrically Stimulating Nerve Regeneration |
| US20060292549A1 (en) * | 2005-06-15 | 2006-12-28 | Neurosilicon | Psychotropic drug screening device based on long-term photoconductive stimulation of neurons |
| JP4907908B2 (ja) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | 駆動回路及び表示装置 |
| US20070092958A1 (en) * | 2005-07-15 | 2007-04-26 | Syed Naweed I | Method and apparatus for guiding growth of neurons |
| US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US7520888B2 (en) * | 2006-02-14 | 2009-04-21 | Warsaw Orthopedic, Inc. | Treatment of the vertebral column |
| US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
| US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| TWI501774B (zh) * | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| ES2450065T3 (es) * | 2006-03-01 | 2014-03-21 | Biogen Idec Ma Inc. | Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF |
| US8945623B2 (en) * | 2006-05-03 | 2015-02-03 | Warsaw Orthopedic, Inc. | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
| US8840933B2 (en) | 2006-05-03 | 2014-09-23 | Warsaw Orthopedic, Inc. | Method of treating neuronal injury by administering magnesium chloride and PEG |
| US9675696B2 (en) | 2006-11-14 | 2017-06-13 | Warsaw Orthopedic, Inc. | Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain |
| US8329655B2 (en) | 2007-05-01 | 2012-12-11 | Biogen Idec Ma Inc. | Methods for increasing vascularization |
| US20110135648A1 (en) * | 2007-08-08 | 2011-06-09 | Biogen Idec Ma Inc. | Anti-neublastin antibodies and uses thereof |
| US20090263507A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use |
| CA2744100C (en) * | 2008-10-21 | 2020-06-30 | The General Hospital Corporation | Cell transplantation |
| US9244060B2 (en) * | 2009-03-26 | 2016-01-26 | Warsaw Orthopedic, Inc. | Site localization and methods for monitoring treatment of disturbed blood vessels |
| US8858924B2 (en) * | 2009-03-26 | 2014-10-14 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
| US9078808B2 (en) * | 2009-03-26 | 2015-07-14 | Warsaw Orthopedic, Inc. | Device to deliver magnesium in PEG formulation |
| US8852566B2 (en) | 2009-03-26 | 2014-10-07 | Warsaw Orthopedic, Inc. | Compositions and methods for preferential distribution of active agents to injury sites |
| WO2010111212A1 (en) | 2009-03-26 | 2010-09-30 | Warsaw Orthopedic, Inc. | Methods of identifying potential components for targeted drug delivery compositions |
| CA2758118C (en) | 2009-04-07 | 2019-05-21 | Catholic Healthcare West | Uterine electrical stimulation system and method |
| US20110230785A1 (en) * | 2010-03-16 | 2011-09-22 | ProNerve, LLC | Somatosensory Evoked Potential (SSEP) Automated Alert System |
| BR112013002859B1 (pt) | 2010-08-06 | 2020-10-06 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Método e aparelho para tratamento de células |
| CA3063888C (en) | 2010-10-27 | 2020-12-22 | Dignity Health | Uterine electrical stimulation system and method |
| WO2013173833A1 (en) * | 2012-05-18 | 2013-11-21 | Dignity Health | Electrical stimulation of the cervix |
| US9872983B2 (en) | 2010-10-27 | 2018-01-23 | Dignity Health | Uterine electrical stimulation system and method |
| WO2012161823A1 (en) * | 2011-02-25 | 2012-11-29 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Nerve coaptation apparatus |
| EP2953640B1 (en) * | 2013-02-07 | 2020-04-08 | The Cleveland Clinic Foundation | Nanoencapsulated superoxide dismutase and catalase for treating spinal cord injury |
| PL3138031T3 (pl) | 2014-04-28 | 2023-04-11 | Yeda Research And Development Co., Ltd. | Sposób i urządzenie do przewidywania odpowiedzi na pokarm |
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| EP3658072B1 (en) | 2017-07-26 | 2024-03-13 | Neuraptive Therapeutics, Inc. | Device for administering therapeutics to a nerve |
| US12458411B2 (en) | 2017-12-07 | 2025-11-04 | Augmedics Ltd. | Spinous process clamp |
| EP3787543A4 (en) | 2018-05-02 | 2022-01-19 | Augmedics Ltd. | REGISTRATION OF A FIDUCIAL MARKER FOR AN AUGMENTED REALITY SYSTEM |
| US11766296B2 (en) | 2018-11-26 | 2023-09-26 | Augmedics Ltd. | Tracking system for image-guided surgery |
| US11980506B2 (en) | 2019-07-29 | 2024-05-14 | Augmedics Ltd. | Fiducial marker |
| US12178666B2 (en) | 2019-07-29 | 2024-12-31 | Augmedics Ltd. | Fiducial marker |
| JP7653164B2 (ja) * | 2019-09-27 | 2025-03-28 | バージニア コモンウェルス ユニバーシティー | 組織を修復または増加させるための組成物および方法 |
| US11382712B2 (en) | 2019-12-22 | 2022-07-12 | Augmedics Ltd. | Mirroring in image guided surgery |
| WO2021150773A1 (en) * | 2020-01-21 | 2021-07-29 | The Penn State Research Foundation | Methods and materials for treating nerve injury and/or promoting wound healing |
| US11389252B2 (en) | 2020-06-15 | 2022-07-19 | Augmedics Ltd. | Rotating marker for image guided surgery |
| US20230190676A1 (en) * | 2020-07-09 | 2023-06-22 | Musc Foundation For Research Development | Methods of protecting cells from insults |
| US12239385B2 (en) | 2020-09-09 | 2025-03-04 | Augmedics Ltd. | Universal tool adapter |
| US11896445B2 (en) | 2021-07-07 | 2024-02-13 | Augmedics Ltd. | Iliac pin and adapter |
| US12150821B2 (en) | 2021-07-29 | 2024-11-26 | Augmedics Ltd. | Rotating marker and adapter for image-guided surgery |
| EP4387552A4 (en) | 2021-08-18 | 2025-04-30 | Augmedics Ltd. | AUGMENTED REALITY SURGICAL SYSTEM USING DEPTH SENSING |
| WO2023203521A1 (en) | 2022-04-21 | 2023-10-26 | Augmedics Ltd. | Systems and methods for medical image visualization |
| US12268677B2 (en) | 2022-04-27 | 2025-04-08 | The Penn State Research Foundation | 4-aminopyridine (4-AP) and bone morphogenetic protein 2 (BMP-2) |
| IL319523A (en) | 2022-09-13 | 2025-05-01 | Augmedics Ltd | Augmented reality glasses for image-guided medical intervention |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369769A (en) | 1980-06-13 | 1983-01-25 | Edwards Charles C | Spinal fixation device and method |
| US4599354A (en) | 1985-03-11 | 1986-07-08 | Morton Shulman | Composition and method for producing prolonged pain relief |
| US6858409B1 (en) * | 1988-05-27 | 2005-02-22 | Amgen Inc. | Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors |
| US4919140A (en) | 1988-10-14 | 1990-04-24 | Purdue Research Foundation | Method and apparatus for regenerating nerves |
| IE82916B1 (en) | 1990-11-02 | 2003-06-11 | Elan Corp Plc | Formulations and their use in the treatment of neurological diseases |
| NL9000634A (nl) | 1990-03-20 | 1991-10-16 | Catharina Ziekenhuis Stichting | Suspensie-injectiepreparaat op waterbasis, werkwijze voor de bereiding daarvan en toepassing van dit preparaat voor pijnbestrijding. |
| CA2075928A1 (en) * | 1991-01-11 | 1992-07-12 | Roger W. Hackett | Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material |
| CN1069741A (zh) | 1991-03-19 | 1993-03-10 | 西特克斯公司 | 具有改进的生物活性的聚氧丙烯/聚氧乙烯共聚物 |
| US5470568A (en) | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
| US5324322A (en) * | 1992-04-20 | 1994-06-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
| US5605687A (en) * | 1992-05-15 | 1997-02-25 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for repair of electrical injury |
| DE69322707T2 (de) | 1992-07-31 | 1999-08-19 | Bristol-Myers Squibb Company | Diphenyl Oxazole-, Thiazole- und Imidazole-Derivate als Inhibitoren der Wiederaufnahme des Adenosins |
| CA2085785C (en) | 1992-12-18 | 2005-03-15 | Robert R. Hansebout | The use of 4-aminopyridine in the treatment of a neurological condition |
| CN1103698C (zh) * | 1995-02-14 | 2003-03-26 | 东丽株式会社 | 平版印刷版及平板印刷版原版 |
| JPH09315972A (ja) | 1996-03-22 | 1997-12-09 | Chugai Pharmaceut Co Ltd | 脊髄損傷治療剤 |
| US6495532B1 (en) * | 1997-03-19 | 2002-12-17 | Sky High, Llc | Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof |
| EP1024812B1 (en) | 1997-03-19 | 2007-01-24 | Sky High, LLC | Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof |
| US6440455B1 (en) | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| US7582680B1 (en) * | 1998-11-12 | 2009-09-01 | Purdue Research Foundation | Methods and compositions for treating mammalian spinal cord injuries |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| AU4363600A (en) * | 1999-04-22 | 2000-11-10 | Department Of The Army, U.S. Government | Treatment of and/or prophylaxis against brain and spinal cord injury |
| NZ543953A (en) | 2001-04-24 | 2007-04-27 | Univ Chicago | Method and compositions for treating mammalian nerve tissue injuries |
| US7199110B2 (en) | 2002-12-30 | 2007-04-03 | Purdue Research Foundation | Method of treatment for spinal cord injury |
-
2002
- 2002-04-24 NZ NZ543953A patent/NZ543953A/en not_active IP Right Cessation
- 2002-04-24 JP JP2002589024A patent/JP2004527573A/ja active Pending
- 2002-04-24 WO PCT/US2002/013375 patent/WO2002092107A1/en not_active Ceased
- 2002-04-24 ES ES02741682T patent/ES2382899T3/es not_active Expired - Lifetime
- 2002-04-24 NZ NZ529526A patent/NZ529526A/en not_active IP Right Cessation
- 2002-04-24 US US10/132,542 patent/US7837987B2/en not_active Expired - Fee Related
- 2002-04-24 AT AT02741682T patent/ATE546146T1/de active
- 2002-04-24 EP EP02741682A patent/EP1389121B1/en not_active Expired - Lifetime
- 2002-04-24 AU AU2002314758A patent/AU2002314758B2/en not_active Ceased
- 2002-04-24 CA CA2740056A patent/CA2740056A1/en not_active Abandoned
- 2002-04-24 CA CA2445612A patent/CA2445612C/en not_active Expired - Fee Related
-
2004
- 2004-07-28 US US10/901,481 patent/US9687502B2/en not_active Expired - Fee Related
-
2006
- 2006-03-01 AU AU2006200866A patent/AU2006200866B2/en not_active Ceased
-
2009
- 2009-02-23 JP JP2009039488A patent/JP2009112835A/ja active Pending
- 2009-07-23 US US12/508,184 patent/US8460646B2/en not_active Expired - Fee Related
-
2013
- 2013-06-07 US US13/912,499 patent/US9101655B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1389121A4 (en) | 2006-11-02 |
| US9687502B2 (en) | 2017-06-27 |
| CA2445612C (en) | 2011-10-25 |
| AU2006200866B2 (en) | 2007-11-08 |
| AU2006200866A1 (en) | 2006-03-23 |
| ATE546146T1 (de) | 2012-03-15 |
| EP1389121A1 (en) | 2004-02-18 |
| US20100016444A1 (en) | 2010-01-21 |
| NZ529526A (en) | 2006-06-30 |
| ES2382899T3 (es) | 2012-06-14 |
| WO2002092107A1 (en) | 2002-11-21 |
| US20030118545A1 (en) | 2003-06-26 |
| CA2445612A1 (en) | 2002-11-21 |
| US8460646B2 (en) | 2013-06-11 |
| US9101655B2 (en) | 2015-08-11 |
| EP1389121B1 (en) | 2012-02-22 |
| JP2009112835A (ja) | 2009-05-28 |
| US20140100289A1 (en) | 2014-04-10 |
| AU2002314758B2 (en) | 2006-06-01 |
| US20050069520A1 (en) | 2005-03-31 |
| US7837987B2 (en) | 2010-11-23 |
| NZ543953A (en) | 2007-04-27 |
| JP2004527573A (ja) | 2004-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2445612C (en) | Methods and compositions for treating mammalian nerve tissue injuries | |
| AU2002314758A1 (en) | Method and composition for treating mammalian nerve tissue injuries | |
| Somjen | Mechanisms of spreading depression and hypoxic spreading depression-like depolarization | |
| Shi et al. | Functional reconnection of severed mammalian spinal cord axons with polyethylene glycol | |
| Gomez-Amaya et al. | Neural reconstruction methods of restoring bladder function | |
| Collins et al. | Structural and functional recovery of electropermeabilized skeletal muscle in-vivo after treatment with surfactant poloxamer 188 | |
| Borgens | Cellular engineering: molecular repair of membranes to rescue cells of the damaged nervous system | |
| EP0626848B1 (en) | The use of 4-aminopyridine in the treatment of pain and spasticity resulting from spinal cord injury | |
| Manto et al. | (4-Aminopyridine)–PLGA–PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury | |
| US7582680B1 (en) | Methods and compositions for treating mammalian spinal cord injuries | |
| Vale et al. | Drugs and the Eye: Sponsored by the British Optical Association | |
| DE69918541T2 (de) | Verwendung von nmda antagonisten zur behandlung des reizkolons | |
| Rotterman et al. | Structural preservation does not ensure function at sensory Ia–motoneuron synapses following peripheral nerve injury and repair | |
| Bitar Alatorre et al. | Critical ischemia time in a model of spinal cord section. A study performed on dogs | |
| Adnyana et al. | A simple method to stimulate ischemic stroke in Wistar rat for animal testing | |
| Seitz et al. | Toxic effects of triethyldodecylammoniumbromide (TEA-C12) on myelinated nerve fibers and blood-nerve barrier in the mouse | |
| Añor | Monoparesis | |
| Francis et al. | Benzalkonium Chloride–Induced Denervation of Orbicularis Oculi Muscle in Rabbits | |
| Hayashi et al. | The electromyographic examination to evaluate the external sphincter muscle in anorectal malformations | |
| Fox et al. | The effect of angiography on the electrophysiological state of the spinal cord: a study in control and traumatized cats | |
| US20200352923A1 (en) | Treatment of side effects of botulinum therapies | |
| Soto | Critical ischemia time in a model of spinal cord section. A study performed on dogs | |
| Borgens | Recovery of Behavioral and Physiological Function In Vivo | |
| Cormier | The role of bulbospinal serotonergic axons in the regulation of blood pressure during noxious stimulation. | |
| Gopinathan | requirement for the degree of |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130524 |